Angiotensin‐converting enzyme inhibitors: Medicinal chemistry and biological actions
A decade of experimentation, with work in the last four years greatly accelerated by the availability of captopril, favors the conclusion that angiotensin-converting enzyme inhibitors exert their antihypertensive effect by blocking the formation of angiotensin II. The apparently anomalous efficacy o...
Gespeichert in:
| Veröffentlicht in: | Medicinal research reviews 1982-01, Vol.2 (1), p.1-41 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 41 |
|---|---|
| container_issue | 1 |
| container_start_page | 1 |
| container_title | Medicinal research reviews |
| container_volume | 2 |
| creator | Petrillo, Edward W. Ondetti, Miguel A. |
| description | A decade of experimentation, with work in the last four years greatly accelerated by the availability of captopril, favors the conclusion that angiotensin-converting enzyme inhibitors exert their antihypertensive effect by blocking the formation of angiotensin II. The apparently anomalous efficacy of ACE inhibitors in hypertension characterized by low circulating renin levels may point to the importance of the vascular renin-angiotensin system in controlling blood pressure. Neither kinin potentiation nor blockade of the CNS renin-angiotensin system appear to play a significant role in the antihypertensive effect of captopril. Pharmacological and clinical studies on ACE inhibitors of novel chemical structure will establish their utility as antihypertensive agents and may lead to greater understanding of the mechanism of action of all ACE inhibitors. |
| doi_str_mv | 10.1002/med.2610020103 |
| format | Article |
| fullrecord | <record><control><sourceid>wiley_pubme</sourceid><recordid>TN_cdi_pubmed_primary_6287131</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>MED2610020103</sourcerecordid><originalsourceid>FETCH-LOGICAL-p1573-ea7f8b51358f9d16269030857637a7ca5d89c1943bb2dfc06ea045250dd757f33</originalsourceid><addsrcrecordid>eNpFkE1OwzAQRi0EKqWwZYeUC6TM2LWdsKtK-ZFasQG2kWM7rVHiVHEAhRVH4IychFSt6Gq-0dOMZh4hlwhjBKDXlTVjKrYRENgRGSKkSYxIk2MyBOyzYJSfkrMQ3gAQObIBGQiaSGQ4JK9Tv3J1a31w_vf7R9f-wzat86vI-q-uspHza5e7tm7CTbS0xmnnVRnpta1caJsuUt5EuavLeuV0D5RuXe3DOTkpVBnsxb6OyMvd_Hn2EC-e7h9n00W8QS5ZbJUskrw_iSdFalBQkQKDhEvBpJJacZOkGtMJy3NqCg3CKphwysEYyWXB2Ihc7fZu3vPeRLZpXKWaLtv_1_N0xz9dabt_jJBtjWXbkYO8bDm_PXTsD8wlZII</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Angiotensin‐converting enzyme inhibitors: Medicinal chemistry and biological actions</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Petrillo, Edward W. ; Ondetti, Miguel A.</creator><creatorcontrib>Petrillo, Edward W. ; Ondetti, Miguel A.</creatorcontrib><description>A decade of experimentation, with work in the last four years greatly accelerated by the availability of captopril, favors the conclusion that angiotensin-converting enzyme inhibitors exert their antihypertensive effect by blocking the formation of angiotensin II. The apparently anomalous efficacy of ACE inhibitors in hypertension characterized by low circulating renin levels may point to the importance of the vascular renin-angiotensin system in controlling blood pressure. Neither kinin potentiation nor blockade of the CNS renin-angiotensin system appear to play a significant role in the antihypertensive effect of captopril. Pharmacological and clinical studies on ACE inhibitors of novel chemical structure will establish their utility as antihypertensive agents and may lead to greater understanding of the mechanism of action of all ACE inhibitors.</description><identifier>ISSN: 0198-6325</identifier><identifier>EISSN: 1098-1128</identifier><identifier>DOI: 10.1002/med.2610020103</identifier><identifier>PMID: 6287131</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Angiotensin-Converting Enzyme Inhibitors ; Animals ; Chemical Phenomena ; Chemistry ; Dipeptides - pharmacology ; Humans ; Hypertension - physiopathology ; Hypertension, Renal - drug therapy ; Kallikreins - physiology ; Kinins - physiology ; Zinc - physiology</subject><ispartof>Medicinal research reviews, 1982-01, Vol.2 (1), p.1-41</ispartof><rights>Copyright © 1982 Wiley Periodicals, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmed.2610020103$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmed.2610020103$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6287131$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Petrillo, Edward W.</creatorcontrib><creatorcontrib>Ondetti, Miguel A.</creatorcontrib><title>Angiotensin‐converting enzyme inhibitors: Medicinal chemistry and biological actions</title><title>Medicinal research reviews</title><addtitle>Med Res Rev</addtitle><description>A decade of experimentation, with work in the last four years greatly accelerated by the availability of captopril, favors the conclusion that angiotensin-converting enzyme inhibitors exert their antihypertensive effect by blocking the formation of angiotensin II. The apparently anomalous efficacy of ACE inhibitors in hypertension characterized by low circulating renin levels may point to the importance of the vascular renin-angiotensin system in controlling blood pressure. Neither kinin potentiation nor blockade of the CNS renin-angiotensin system appear to play a significant role in the antihypertensive effect of captopril. Pharmacological and clinical studies on ACE inhibitors of novel chemical structure will establish their utility as antihypertensive agents and may lead to greater understanding of the mechanism of action of all ACE inhibitors.</description><subject>Angiotensin-Converting Enzyme Inhibitors</subject><subject>Animals</subject><subject>Chemical Phenomena</subject><subject>Chemistry</subject><subject>Dipeptides - pharmacology</subject><subject>Humans</subject><subject>Hypertension - physiopathology</subject><subject>Hypertension, Renal - drug therapy</subject><subject>Kallikreins - physiology</subject><subject>Kinins - physiology</subject><subject>Zinc - physiology</subject><issn>0198-6325</issn><issn>1098-1128</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1OwzAQRi0EKqWwZYeUC6TM2LWdsKtK-ZFasQG2kWM7rVHiVHEAhRVH4IychFSt6Gq-0dOMZh4hlwhjBKDXlTVjKrYRENgRGSKkSYxIk2MyBOyzYJSfkrMQ3gAQObIBGQiaSGQ4JK9Tv3J1a31w_vf7R9f-wzat86vI-q-uspHza5e7tm7CTbS0xmnnVRnpta1caJsuUt5EuavLeuV0D5RuXe3DOTkpVBnsxb6OyMvd_Hn2EC-e7h9n00W8QS5ZbJUskrw_iSdFalBQkQKDhEvBpJJacZOkGtMJy3NqCg3CKphwysEYyWXB2Ihc7fZu3vPeRLZpXKWaLtv_1_N0xz9dabt_jJBtjWXbkYO8bDm_PXTsD8wlZII</recordid><startdate>198201</startdate><enddate>198201</enddate><creator>Petrillo, Edward W.</creator><creator>Ondetti, Miguel A.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>198201</creationdate><title>Angiotensin‐converting enzyme inhibitors: Medicinal chemistry and biological actions</title><author>Petrillo, Edward W. ; Ondetti, Miguel A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p1573-ea7f8b51358f9d16269030857637a7ca5d89c1943bb2dfc06ea045250dd757f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Angiotensin-Converting Enzyme Inhibitors</topic><topic>Animals</topic><topic>Chemical Phenomena</topic><topic>Chemistry</topic><topic>Dipeptides - pharmacology</topic><topic>Humans</topic><topic>Hypertension - physiopathology</topic><topic>Hypertension, Renal - drug therapy</topic><topic>Kallikreins - physiology</topic><topic>Kinins - physiology</topic><topic>Zinc - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Petrillo, Edward W.</creatorcontrib><creatorcontrib>Ondetti, Miguel A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Medicinal research reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Petrillo, Edward W.</au><au>Ondetti, Miguel A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Angiotensin‐converting enzyme inhibitors: Medicinal chemistry and biological actions</atitle><jtitle>Medicinal research reviews</jtitle><addtitle>Med Res Rev</addtitle><date>1982-01</date><risdate>1982</risdate><volume>2</volume><issue>1</issue><spage>1</spage><epage>41</epage><pages>1-41</pages><issn>0198-6325</issn><eissn>1098-1128</eissn><abstract>A decade of experimentation, with work in the last four years greatly accelerated by the availability of captopril, favors the conclusion that angiotensin-converting enzyme inhibitors exert their antihypertensive effect by blocking the formation of angiotensin II. The apparently anomalous efficacy of ACE inhibitors in hypertension characterized by low circulating renin levels may point to the importance of the vascular renin-angiotensin system in controlling blood pressure. Neither kinin potentiation nor blockade of the CNS renin-angiotensin system appear to play a significant role in the antihypertensive effect of captopril. Pharmacological and clinical studies on ACE inhibitors of novel chemical structure will establish their utility as antihypertensive agents and may lead to greater understanding of the mechanism of action of all ACE inhibitors.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>6287131</pmid><doi>10.1002/med.2610020103</doi><tpages>41</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0198-6325 |
| ispartof | Medicinal research reviews, 1982-01, Vol.2 (1), p.1-41 |
| issn | 0198-6325 1098-1128 |
| language | eng |
| recordid | cdi_pubmed_primary_6287131 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Angiotensin-Converting Enzyme Inhibitors Animals Chemical Phenomena Chemistry Dipeptides - pharmacology Humans Hypertension - physiopathology Hypertension, Renal - drug therapy Kallikreins - physiology Kinins - physiology Zinc - physiology |
| title | Angiotensin‐converting enzyme inhibitors: Medicinal chemistry and biological actions |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T11%3A07%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-wiley_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Angiotensin%E2%80%90converting%20enzyme%20inhibitors:%20Medicinal%20chemistry%20and%20biological%20actions&rft.jtitle=Medicinal%20research%20reviews&rft.au=Petrillo,%20Edward%20W.&rft.date=1982-01&rft.volume=2&rft.issue=1&rft.spage=1&rft.epage=41&rft.pages=1-41&rft.issn=0198-6325&rft.eissn=1098-1128&rft_id=info:doi/10.1002/med.2610020103&rft_dat=%3Cwiley_pubme%3EMED2610020103%3C/wiley_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/6287131&rfr_iscdi=true |