Modulation of 5-fluorouracil metabolism by thymidine: In vivo and in vitro studies on RNA-directed effects in rat liver and hepatoma

The effects of thymidine (TdR) co-administration on the cytotoxicity and incorporation of 5-fluorouracil (5-FU) into RNA of various tissues was studied in rats bearing an ascites hepatoma (AH 130). The role of pyrimidine degradation in determining the modulating effects of TdR on the formation of FU...

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Veröffentlicht in:	Biochemical pharmacology 1984-03, Vol.33 (5), p.745-750
Hauptverfasser:	Engelbrecht, Claes, Ljungquist, Inga, Lewan, Lillemor, Yngner, Torsten
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body Weight - drug effects Bone Marrow - metabolism Cell Survival - drug effects Fluorouracil - metabolism Intestinal Mucosa - metabolism Liver - metabolism Liver Neoplasms, Experimental - metabolism Male Rats Rats, Inbred Strains RNA - metabolism Thymidine - pharmacology
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