Suppression of Liver Uptake of Liposomes by Dextran Sulfate 500
The effect of dextran sulfate (DS, 500,000 Mr) and multilamellar vesicles (MLV) as liver blockade agents has been investigated in mice. Intravenous injection of unlabeled MLV prior to radioactive MLV caused moderate reduction in the liver uptake and increased tibia, lung, and spleen uptake. More dra...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1983-11, Vol.80 (21), p.6518-6522 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Patel, Kanaiyalal R. Li, Ming P. Baldeschwieler, John D. |
| description | The effect of dextran sulfate (DS, 500,000 Mr) and multilamellar vesicles (MLV) as liver blockade agents has been investigated in mice. Intravenous injection of unlabeled MLV prior to radioactive MLV caused moderate reduction in the liver uptake and increased tibia, lung, and spleen uptake. More drastic differences were observed with intraperitoneal injection of DS. When tested in the range of 0--50 mg of DS per kg of body weight, maximal liver blockade occurred at a dose of 50 mg. By using 50 mg of DS per kg, maximal liver blockade occurred at 12 hr after DS injection. The liver blockade was temporary, ending within 48 hr. The intraperitoneal route of injection for DS was more effective for liver blockade than the intravenous route. |
| doi_str_mv | 10.1073/pnas.80.21.6518 |
| format | Article |
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Intravenous injection of unlabeled MLV prior to radioactive MLV caused moderate reduction in the liver uptake and increased tibia, lung, and spleen uptake. More drastic differences were observed with intraperitoneal injection of DS. When tested in the range of 0--50 mg of DS per kg of body weight, maximal liver blockade occurred at a dose of 50 mg. By using 50 mg of DS per kg, maximal liver blockade occurred at 12 hr after DS injection. The liver blockade was temporary, ending within 48 hr. The intraperitoneal route of injection for DS was more effective for liver blockade than the intravenous route.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.80.21.6518</identifier><identifier>PMID: 6195658</identifier><language>eng</language><publisher>United States: National Academy of Sciences of the United States of America</publisher><subject>Animals ; Biological Transport - drug effects ; Blood ; Body weight ; Dextran Sulfate ; Dextrans ; Dextrans - pharmacology ; Dosage ; Kinetics ; Liposomes ; Liposomes - administration & dosage ; Liposomes - metabolism ; Liver ; Liver - metabolism ; Lungs ; Macrophages - drug effects ; Mice ; Mononuclear Phagocyte System - drug effects ; Phagocytosis - drug effects ; Spleen ; Sulfates ; Tibia ; Tissue Distribution</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1983-11, Vol.80 (21), p.6518-6522</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-85b35f3cc0a04fb966cc1d82f2e72abc8e42dfecd1c712590f2e3541985323b13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/80/21.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/22901$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/22901$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27922,27923,53789,53791,58015,58248</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6195658$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Patel, Kanaiyalal R.</creatorcontrib><creatorcontrib>Li, Ming P.</creatorcontrib><creatorcontrib>Baldeschwieler, John D.</creatorcontrib><title>Suppression of Liver Uptake of Liposomes by Dextran Sulfate 500</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>The effect of dextran sulfate (DS, 500,000 Mr) and multilamellar vesicles (MLV) as liver blockade agents has been investigated in mice. Intravenous injection of unlabeled MLV prior to radioactive MLV caused moderate reduction in the liver uptake and increased tibia, lung, and spleen uptake. More drastic differences were observed with intraperitoneal injection of DS. When tested in the range of 0--50 mg of DS per kg of body weight, maximal liver blockade occurred at a dose of 50 mg. By using 50 mg of DS per kg, maximal liver blockade occurred at 12 hr after DS injection. The liver blockade was temporary, ending within 48 hr. The intraperitoneal route of injection for DS was more effective for liver blockade than the intravenous route.</description><subject>Animals</subject><subject>Biological Transport - drug effects</subject><subject>Blood</subject><subject>Body weight</subject><subject>Dextran Sulfate</subject><subject>Dextrans</subject><subject>Dextrans - pharmacology</subject><subject>Dosage</subject><subject>Kinetics</subject><subject>Liposomes</subject><subject>Liposomes - administration & dosage</subject><subject>Liposomes - metabolism</subject><subject>Liver</subject><subject>Liver - metabolism</subject><subject>Lungs</subject><subject>Macrophages - drug effects</subject><subject>Mice</subject><subject>Mononuclear Phagocyte System - drug effects</subject><subject>Phagocytosis - drug effects</subject><subject>Spleen</subject><subject>Sulfates</subject><subject>Tibia</subject><subject>Tissue Distribution</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLAzEURoMotT7WgqDMSldTb5LJNFmIiG8ouNCuQyZNdHQ6GZOZYv-9Ka1VN67C5TvfzeUgdIBhgGFIz5pahQGHAcGDnGG-gfoYBE7zTMAm6gOQYcozkm2jnRDeAEAwDj3Uy7FgOeN9dPHUNY03IZSuTpxNRuXM-GTctOrdLOfGBTc1ISnmybX5bL2qk6eusqo1CQPYQ1tWVcHsr95dNL69eb66T0ePdw9Xl6NUx0valLOCMku1BgWZLUSea40nnFhihkQVmpuMTKzRE6yHmDABMaAsw4IzSmiB6S46X-5tumJqJtrU8ZJKNr6cKj-XTpXyb1KXr_LFzSQVQHkW-yervncfnQmtnJZBm6pStXFdkDzKzCmDCJ4tQe1dCN7Y9R8Y5EK5XCiPvCRYLpTHxtHv09b8ynHMT1f5ovid_iyQtquqNqqN5PG_ZAQOl8BbaJ1fE4QIwPQLIa-eKg</recordid><startdate>19831101</startdate><enddate>19831101</enddate><creator>Patel, Kanaiyalal R.</creator><creator>Li, Ming P.</creator><creator>Baldeschwieler, John D.</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19831101</creationdate><title>Suppression of Liver Uptake of Liposomes by Dextran Sulfate 500</title><author>Patel, Kanaiyalal R. ; Li, Ming P. ; Baldeschwieler, John D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-85b35f3cc0a04fb966cc1d82f2e72abc8e42dfecd1c712590f2e3541985323b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Biological Transport - drug effects</topic><topic>Blood</topic><topic>Body weight</topic><topic>Dextran Sulfate</topic><topic>Dextrans</topic><topic>Dextrans - pharmacology</topic><topic>Dosage</topic><topic>Kinetics</topic><topic>Liposomes</topic><topic>Liposomes - administration & dosage</topic><topic>Liposomes - metabolism</topic><topic>Liver</topic><topic>Liver - metabolism</topic><topic>Lungs</topic><topic>Macrophages - drug effects</topic><topic>Mice</topic><topic>Mononuclear Phagocyte System - drug effects</topic><topic>Phagocytosis - drug effects</topic><topic>Spleen</topic><topic>Sulfates</topic><topic>Tibia</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Patel, Kanaiyalal R.</creatorcontrib><creatorcontrib>Li, Ming P.</creatorcontrib><creatorcontrib>Baldeschwieler, John D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Patel, Kanaiyalal R.</au><au>Li, Ming P.</au><au>Baldeschwieler, John D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Suppression of Liver Uptake of Liposomes by Dextran Sulfate 500</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1983-11-01</date><risdate>1983</risdate><volume>80</volume><issue>21</issue><spage>6518</spage><epage>6522</epage><pages>6518-6522</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>The effect of dextran sulfate (DS, 500,000 Mr) and multilamellar vesicles (MLV) as liver blockade agents has been investigated in mice. Intravenous injection of unlabeled MLV prior to radioactive MLV caused moderate reduction in the liver uptake and increased tibia, lung, and spleen uptake. More drastic differences were observed with intraperitoneal injection of DS. When tested in the range of 0--50 mg of DS per kg of body weight, maximal liver blockade occurred at a dose of 50 mg. By using 50 mg of DS per kg, maximal liver blockade occurred at 12 hr after DS injection. The liver blockade was temporary, ending within 48 hr. The intraperitoneal route of injection for DS was more effective for liver blockade than the intravenous route.</abstract><cop>United States</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>6195658</pmid><doi>10.1073/pnas.80.21.6518</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1983-11, Vol.80 (21), p.6518-6522 |
| issn | 0027-8424 1091-6490 |
| language | eng |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Animals Biological Transport - drug effects Blood Body weight Dextran Sulfate Dextrans Dextrans - pharmacology Dosage Kinetics Liposomes Liposomes - administration & dosage Liposomes - metabolism Liver Liver - metabolism Lungs Macrophages - drug effects Mice Mononuclear Phagocyte System - drug effects Phagocytosis - drug effects Spleen Sulfates Tibia Tissue Distribution |
| title | Suppression of Liver Uptake of Liposomes by Dextran Sulfate 500 |
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