Effect of various types of analgesic drugs on an experimental model of chronic inflammatory pain in mice
We attempted to develop an experimental model of chronic inflammatory pain in mice. The mice were injected intradermally at the base of the tail with various kinds of irritants (yeast, carrageenin, mustard and adjuvant). The pain threshold was measured by the pressure method every 60 min for 5 hr an...
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| Veröffentlicht in: | Folia Pharmacologica Japonica 1984, Vol.83(6), pp.513-521 |
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| container_title | Folia Pharmacologica Japonica |
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| creator | OKUYAMA, Shigeru HASHIMOTO, Sanae AMANUMA, Fusao AIHARA, Hironaka |
| description | We attempted to develop an experimental model of chronic inflammatory pain in mice. The mice were injected intradermally at the base of the tail with various kinds of irritants (yeast, carrageenin, mustard and adjuvant). The pain threshold was measured by the pressure method every 60 min for 5 hr and once a day at the same time throughout the experimental period. The group of 10% yeast-injected mice exhibited the most intensive hyperalgesia. The analgesic effect of various types of analgesic drugs were studied, comparing the effects in normal mice and various kinds of irritants-induced hyperalgesia mice. It was demonstrated by observing ED50 values that nonsteroidal antiinflammatory drugs (NSAIDs), narcotic analgesic drugs and agonist/antagonist type of analgesic drugs were effective, but CNS-acting drugs were ineffective in yeast hyperalgesia mice. In comparison with yeast hyperalgesia mice, larger doses of analgesic drugs were required in normal mice and other irritants-treated mice. Especially, acidic NSAIDs were more effective in yeast hyperalgesia mice than normal mice. It was suggested that acidic NSAIDs specifically inhibit inflammatory pain. Moreover, yeast hyperalgesia mice are useful for the quantitative measurement of analgesic drugs. |
| doi_str_mv | 10.1254/fpj.83.513 |
| format | Article |
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The mice were injected intradermally at the base of the tail with various kinds of irritants (yeast, carrageenin, mustard and adjuvant). The pain threshold was measured by the pressure method every 60 min for 5 hr and once a day at the same time throughout the experimental period. The group of 10% yeast-injected mice exhibited the most intensive hyperalgesia. The analgesic effect of various types of analgesic drugs were studied, comparing the effects in normal mice and various kinds of irritants-induced hyperalgesia mice. It was demonstrated by observing ED50 values that nonsteroidal antiinflammatory drugs (NSAIDs), narcotic analgesic drugs and agonist/antagonist type of analgesic drugs were effective, but CNS-acting drugs were ineffective in yeast hyperalgesia mice. In comparison with yeast hyperalgesia mice, larger doses of analgesic drugs were required in normal mice and other irritants-treated mice. Especially, acidic NSAIDs were more effective in yeast hyperalgesia mice than normal mice. It was suggested that acidic NSAIDs specifically inhibit inflammatory pain. Moreover, yeast hyperalgesia mice are useful for the quantitative measurement of analgesic drugs.</description><identifier>ISSN: 0015-5691</identifier><identifier>EISSN: 1347-8397</identifier><identifier>DOI: 10.1254/fpj.83.513</identifier><identifier>PMID: 6149173</identifier><language>jpn</language><publisher>Japan: The Japanese Pharmacological Society</publisher><subject>Analgesics - therapeutic use ; Analgesics, Opioid - therapeutic use ; Animals ; Anti-Inflammatory Agents - therapeutic use ; Chronic Disease ; Disease Models, Animal ; Inflammation - chemically induced ; Irritants - antagonists & inhibitors ; Male ; Mice ; Narcotic Antagonists - therapeutic use ; Pain - drug therapy ; Sensory Thresholds</subject><ispartof>Folia Pharmacologica Japonica, 1984, Vol.83(6), pp.513-521</ispartof><rights>The Japanese PharmacologicalSociety</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c307t-803c538e52f16aef6a0ed5a386af67001abcf70f98f49ec1cf95ecb99490eae73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6149173$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>OKUYAMA, Shigeru</creatorcontrib><creatorcontrib>HASHIMOTO, Sanae</creatorcontrib><creatorcontrib>AMANUMA, Fusao</creatorcontrib><creatorcontrib>AIHARA, Hironaka</creatorcontrib><title>Effect of various types of analgesic drugs on an experimental model of chronic inflammatory pain in mice</title><title>Folia Pharmacologica Japonica</title><addtitle>Nihon Yakurigaku Zasshi</addtitle><description>We attempted to develop an experimental model of chronic inflammatory pain in mice. The mice were injected intradermally at the base of the tail with various kinds of irritants (yeast, carrageenin, mustard and adjuvant). The pain threshold was measured by the pressure method every 60 min for 5 hr and once a day at the same time throughout the experimental period. The group of 10% yeast-injected mice exhibited the most intensive hyperalgesia. The analgesic effect of various types of analgesic drugs were studied, comparing the effects in normal mice and various kinds of irritants-induced hyperalgesia mice. It was demonstrated by observing ED50 values that nonsteroidal antiinflammatory drugs (NSAIDs), narcotic analgesic drugs and agonist/antagonist type of analgesic drugs were effective, but CNS-acting drugs were ineffective in yeast hyperalgesia mice. In comparison with yeast hyperalgesia mice, larger doses of analgesic drugs were required in normal mice and other irritants-treated mice. Especially, acidic NSAIDs were more effective in yeast hyperalgesia mice than normal mice. It was suggested that acidic NSAIDs specifically inhibit inflammatory pain. Moreover, yeast hyperalgesia mice are useful for the quantitative measurement of analgesic drugs.</description><subject>Analgesics - therapeutic use</subject><subject>Analgesics, Opioid - therapeutic use</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Chronic Disease</subject><subject>Disease Models, Animal</subject><subject>Inflammation - chemically induced</subject><subject>Irritants - antagonists & inhibitors</subject><subject>Male</subject><subject>Mice</subject><subject>Narcotic Antagonists - therapeutic use</subject><subject>Pain - drug therapy</subject><subject>Sensory Thresholds</subject><issn>0015-5691</issn><issn>1347-8397</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1rAjEQxUNpsWK99F7IP7A2MZuvYxFbC0Iv7XmZzU40sl9k11L_-0YULzPwe49h3iPkmbMFX8r81feHhRELycUdmXKR68wIq-_JlDEuM6ksfyTzYQglY1IvtRJ8QiaK55ZrMSX7tffoRtp5-gsxdMeBjqcehzOAFuodDsHRKh53CbUJUfzrMYYG2xFq2nQV1mev28euTc7Q-hqaBsYunmgPoU2ENsHhE3nwUA84v-4Z-Xlff6822fbr43P1ts2cYHrMDBNOCoNy6bkC9AoYVhKEUeCVTpGgdF4zb43PLTruvJXoSmtzyxBQixl5udztj2WDVdGnXyGeimvipK8u-mEYYYc3HeIYXI1FqpPbPC-MKNRlpGZvqttDLLAV_84IciM</recordid><startdate>198406</startdate><enddate>198406</enddate><creator>OKUYAMA, Shigeru</creator><creator>HASHIMOTO, Sanae</creator><creator>AMANUMA, Fusao</creator><creator>AIHARA, Hironaka</creator><general>The Japanese Pharmacological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>198406</creationdate><title>Effect of various types of analgesic drugs on an experimental model of chronic inflammatory pain in mice</title><author>OKUYAMA, Shigeru ; HASHIMOTO, Sanae ; AMANUMA, Fusao ; AIHARA, Hironaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c307t-803c538e52f16aef6a0ed5a386af67001abcf70f98f49ec1cf95ecb99490eae73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1984</creationdate><topic>Analgesics - therapeutic use</topic><topic>Analgesics, Opioid - therapeutic use</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Chronic Disease</topic><topic>Disease Models, Animal</topic><topic>Inflammation - chemically induced</topic><topic>Irritants - antagonists & inhibitors</topic><topic>Male</topic><topic>Mice</topic><topic>Narcotic Antagonists - therapeutic use</topic><topic>Pain - drug therapy</topic><topic>Sensory Thresholds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OKUYAMA, Shigeru</creatorcontrib><creatorcontrib>HASHIMOTO, Sanae</creatorcontrib><creatorcontrib>AMANUMA, Fusao</creatorcontrib><creatorcontrib>AIHARA, Hironaka</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Folia Pharmacologica Japonica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OKUYAMA, Shigeru</au><au>HASHIMOTO, Sanae</au><au>AMANUMA, Fusao</au><au>AIHARA, Hironaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of various types of analgesic drugs on an experimental model of chronic inflammatory pain in mice</atitle><jtitle>Folia Pharmacologica Japonica</jtitle><addtitle>Nihon Yakurigaku Zasshi</addtitle><date>1984-06</date><risdate>1984</risdate><volume>83</volume><issue>6</issue><spage>513</spage><epage>521</epage><pages>513-521</pages><issn>0015-5691</issn><eissn>1347-8397</eissn><abstract>We attempted to develop an experimental model of chronic inflammatory pain in mice. The mice were injected intradermally at the base of the tail with various kinds of irritants (yeast, carrageenin, mustard and adjuvant). The pain threshold was measured by the pressure method every 60 min for 5 hr and once a day at the same time throughout the experimental period. The group of 10% yeast-injected mice exhibited the most intensive hyperalgesia. The analgesic effect of various types of analgesic drugs were studied, comparing the effects in normal mice and various kinds of irritants-induced hyperalgesia mice. It was demonstrated by observing ED50 values that nonsteroidal antiinflammatory drugs (NSAIDs), narcotic analgesic drugs and agonist/antagonist type of analgesic drugs were effective, but CNS-acting drugs were ineffective in yeast hyperalgesia mice. In comparison with yeast hyperalgesia mice, larger doses of analgesic drugs were required in normal mice and other irritants-treated mice. Especially, acidic NSAIDs were more effective in yeast hyperalgesia mice than normal mice. It was suggested that acidic NSAIDs specifically inhibit inflammatory pain. Moreover, yeast hyperalgesia mice are useful for the quantitative measurement of analgesic drugs.</abstract><cop>Japan</cop><pub>The Japanese Pharmacological Society</pub><pmid>6149173</pmid><doi>10.1254/fpj.83.513</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0015-5691 |
| ispartof | Folia Pharmacologica Japonica, 1984, Vol.83(6), pp.513-521 |
| issn | 0015-5691 1347-8397 |
| language | jpn |
| recordid | cdi_pubmed_primary_6149173 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Analgesics - therapeutic use Analgesics, Opioid - therapeutic use Animals Anti-Inflammatory Agents - therapeutic use Chronic Disease Disease Models, Animal Inflammation - chemically induced Irritants - antagonists & inhibitors Male Mice Narcotic Antagonists - therapeutic use Pain - drug therapy Sensory Thresholds |
| title | Effect of various types of analgesic drugs on an experimental model of chronic inflammatory pain in mice |
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