Inhibition of liver surface membrane Na+, K+-adenosine triphosphatase, Mg+2-adenosine triphosphatase and 5′- nucleotidase activities by protoporphyrin: Observations in vitro and in the perfused rat liver

To clarify the pathogenesis of protoporphyrin-induced cholestasis, liver surface membrane enzyme activities were determined after (a) isolated rat liver perfusion with protoporphyrin administered by bolus (1.0 μmol) or bolus plus constant infusion (1.0 μmol + 0.05 μmol/min) and (b) combination of li...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 1983-09, Vol.85 (3), p.700-706
Hauptverfasser:	Avner, Dennis L., Larsen, Ryan, Berenson, Malcolm M.
Format:	Artikel
Sprache:	eng
Schlagworte:	5'-Nucleotidase Adenosine Triphosphatases - antagonists & inhibitors Animals Ca(2+) Mg(2+)-ATPase Cell Membrane - drug effects Cell Membrane - enzymology In Vitro Techniques Liver - drug effects Liver - enzymology Mitochondria, Liver - drug effects Mitochondria, Liver - enzymology Nucleotidases - antagonists & inhibitors Perfusion Porphyrins - pharmacology Protoporphyrins - pharmacology Rats Rats, Inbred Strains Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors Succinate Cytochrome c Oxidoreductase - antagonists & inhibitors
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