Pharmacological study of Mequitazine (LM-209) (I) Antagonistic actions of chemical mediators

Antagonistic activities of Mequitazine (LM-209) on chemical mediators and in particular histamine were investigated in guinea-pigs, mice and rats. The antagonistic activity of LM-209 for histamine in the isolated ileum and trachea of guinea-pigs was less potent than that for clemastine fumarate (CL)...

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Veröffentlicht in:	Folia Pharmacologica Japonica 1981, Vol.78(4), pp.279-289
Hauptverfasser:	FUJIMURA, Hajime, TSURUMI, Kaito, YANAGIHARA, Masayoshi, HIRAMATSU, Yasuzo, TAMURA, Yohei, SHIMIZU, Yoan, HOJO, Masakazu, YOSHIDA, Yoichi
Format:	Artikel
Sprache:	jpn
Schlagworte:	Acetylcholine - antagonists & inhibitors Airway Resistance - drug effects Animals Bradykinin - antagonists & inhibitors Capillary Permeability - drug effects Female Guinea Pigs Histamine H1 Antagonists - pharmacology Ileum - drug effects In Vitro Techniques Male Mice Muscle Contraction - drug effects Muscle, Smooth - drug effects Phenothiazines - pharmacology Rats Rats, Inbred Strains Stomach Ulcer - chemically induced Stomach Ulcer - prevention & control Trachea - drug effects
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