Influenza A Virus Interaction with Murine Lymphocytes: I. The Influence of Influenza Virus A/Japan 305 (H2N2) on the Pattern of Migration of Recirculating Lymphocytes
The effect of influenza virus A/Japan 305 (H2N2) on the path of migration of recirculating lymphocytes has been studied. 51Cr-labeled rat thoracic duct lymphocytes (TDL) were incubated with virus at 37 degrees C for 1 hr and then infused i.v. into syngeneic recipients which were killed 1 hr later. V...
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Veröffentlicht in: | The Journal of immunology (1950) 1976-09, Vol.117 (3), p.852 |
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description | The effect of influenza virus A/Japan 305 (H2N2) on the path of migration of recirculating lymphocytes has been studied. 51Cr-labeled rat thoracic duct lymphocytes (TDL) were incubated with virus at 37 degrees C for 1 hr and then infused i.v. into syngeneic recipients which were killed 1 hr later. Virus-treated TDL accumulated in the liver and their recovery in lymph nodes and spleen was severely reduced. Changes in lymphocytes induced by virus developed rapidly and were evident after incubation for only 15 min. UV-irradiated virus altered the pattern of lymphocyte localization but attachment of heat-inactivated virus to lymphocytes in vitro had no effect on their distribution in vivo. Evidence was obtained that some virus-treated TDL, initially sequestered in the liver, subsequently recovered their ability to circulate normally. Recovery was not complete and a population of cells failed to regain their ability to home into lymph nodes. Evidence is also presented demonstrating that influenza virus affected the homing properties of both T and B cells. It is suggested that aberrations in lymphocyte homing were mediated by the viral neuraminidase which induces changes in the cell membrane leading to their accumulation in the liver. |
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The Influence of Influenza Virus A/Japan 305 (H2N2) on the Pattern of Migration of Recirculating Lymphocytes</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Woodruff, Judith J ; Woodruff, Jack F</creator><creatorcontrib>Woodruff, Judith J ; Woodruff, Jack F</creatorcontrib><description>The effect of influenza virus A/Japan 305 (H2N2) on the path of migration of recirculating lymphocytes has been studied. 51Cr-labeled rat thoracic duct lymphocytes (TDL) were incubated with virus at 37 degrees C for 1 hr and then infused i.v. into syngeneic recipients which were killed 1 hr later. Virus-treated TDL accumulated in the liver and their recovery in lymph nodes and spleen was severely reduced. Changes in lymphocytes induced by virus developed rapidly and were evident after incubation for only 15 min. UV-irradiated virus altered the pattern of lymphocyte localization but attachment of heat-inactivated virus to lymphocytes in vitro had no effect on their distribution in vivo. Evidence was obtained that some virus-treated TDL, initially sequestered in the liver, subsequently recovered their ability to circulate normally. Recovery was not complete and a population of cells failed to regain their ability to home into lymph nodes. Evidence is also presented demonstrating that influenza virus affected the homing properties of both T and B cells. It is suggested that aberrations in lymphocyte homing were mediated by the viral neuraminidase which induces changes in the cell membrane leading to their accumulation in the liver.</description><identifier>ISSN: 0022-1767</identifier><identifier>EISSN: 1550-6606</identifier><identifier>PMID: 60451</identifier><language>eng</language><publisher>United States: Am Assoc Immnol</publisher><subject>alpha-Fetoproteins - pharmacology ; Animals ; B-Lymphocytes - immunology ; Cell Movement - drug effects ; Influenza A virus - enzymology ; Influenza A virus - immunology ; Influenza A virus - radiation effects ; Influenza A Virus, H2N2 Subtype ; Liver - cytology ; Lung - cytology ; Lymph Nodes - cytology ; Lymphocytes - immunology ; Neuraminidase - metabolism ; Orthomyxoviridae - immunology ; Radiation Effects ; Rats ; Rats, Inbred Strains ; Receptors, Drug ; Spleen - cytology ; Surface Properties ; T-Lymphocytes - immunology ; Temperature ; Time Factors ; Ultraviolet Rays ; Virus Replication</subject><ispartof>The Journal of immunology (1950), 1976-09, Vol.117 (3), p.852</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/60451$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Woodruff, Judith J</creatorcontrib><creatorcontrib>Woodruff, Jack F</creatorcontrib><title>Influenza A Virus Interaction with Murine Lymphocytes: I. The Influence of Influenza Virus A/Japan 305 (H2N2) on the Pattern of Migration of Recirculating Lymphocytes</title><title>The Journal of immunology (1950)</title><addtitle>J Immunol</addtitle><description>The effect of influenza virus A/Japan 305 (H2N2) on the path of migration of recirculating lymphocytes has been studied. 51Cr-labeled rat thoracic duct lymphocytes (TDL) were incubated with virus at 37 degrees C for 1 hr and then infused i.v. into syngeneic recipients which were killed 1 hr later. Virus-treated TDL accumulated in the liver and their recovery in lymph nodes and spleen was severely reduced. Changes in lymphocytes induced by virus developed rapidly and were evident after incubation for only 15 min. UV-irradiated virus altered the pattern of lymphocyte localization but attachment of heat-inactivated virus to lymphocytes in vitro had no effect on their distribution in vivo. Evidence was obtained that some virus-treated TDL, initially sequestered in the liver, subsequently recovered their ability to circulate normally. Recovery was not complete and a population of cells failed to regain their ability to home into lymph nodes. Evidence is also presented demonstrating that influenza virus affected the homing properties of both T and B cells. It is suggested that aberrations in lymphocyte homing were mediated by the viral neuraminidase which induces changes in the cell membrane leading to their accumulation in the liver.</description><subject>alpha-Fetoproteins - pharmacology</subject><subject>Animals</subject><subject>B-Lymphocytes - immunology</subject><subject>Cell Movement - drug effects</subject><subject>Influenza A virus - enzymology</subject><subject>Influenza A virus - immunology</subject><subject>Influenza A virus - radiation effects</subject><subject>Influenza A Virus, H2N2 Subtype</subject><subject>Liver - cytology</subject><subject>Lung - cytology</subject><subject>Lymph Nodes - cytology</subject><subject>Lymphocytes - immunology</subject><subject>Neuraminidase - metabolism</subject><subject>Orthomyxoviridae - immunology</subject><subject>Radiation Effects</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, Drug</subject><subject>Spleen - cytology</subject><subject>Surface Properties</subject><subject>T-Lymphocytes - immunology</subject><subject>Temperature</subject><subject>Time Factors</subject><subject>Ultraviolet Rays</subject><subject>Virus Replication</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkFFLwzAUhYM4dE5_gS95En2oJk2TrL6NMV1lU5Hpa0nTZI20WUlbyvxB_k7jNtCnyz3nnu_APQJDTCkKGEPsGAwRCsMAc8ZPwVnTfCKEGAqjEzBgKKJ4CL4Tq8tO2S8BJ_DDuK6BiW2VE7I1Gwt70xZw2TljFVxsq7rYyG2rmnuY3MJVoeAhLRXcaPiH2oMmd0-iFhYSROH1PHwOb6BHtj72KlrfYX9DS7N2YtfllzcljZNd6QW7_l94DgZalI26OMwReH-YrabzYPHymEwni6DAOG4DElOkWUZzTRhVWSS54oiSSCmMNYu9kuuc8DyTkY4JkSzmfEwzjrn20liTEbjcc-suq1Se1s5Uwm3T3be8e7V3C7MueuNU2lSiLP0tTvu-x5inJB3TkPwAVa91aw</recordid><startdate>197609</startdate><enddate>197609</enddate><creator>Woodruff, Judith J</creator><creator>Woodruff, Jack F</creator><general>Am Assoc Immnol</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>197609</creationdate><title>Influenza A Virus Interaction with Murine Lymphocytes: I. The Influence of Influenza Virus A/Japan 305 (H2N2) on the Pattern of Migration of Recirculating Lymphocytes</title><author>Woodruff, Judith J ; Woodruff, Jack F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h119t-3950f6b5df365eb4c7e70534ee11f69eb4dfd37dbc4f933c697785b717fbc48f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>alpha-Fetoproteins - pharmacology</topic><topic>Animals</topic><topic>B-Lymphocytes - immunology</topic><topic>Cell Movement - drug effects</topic><topic>Influenza A virus - enzymology</topic><topic>Influenza A virus - immunology</topic><topic>Influenza A virus - radiation effects</topic><topic>Influenza A Virus, H2N2 Subtype</topic><topic>Liver - cytology</topic><topic>Lung - cytology</topic><topic>Lymph Nodes - cytology</topic><topic>Lymphocytes - immunology</topic><topic>Neuraminidase - metabolism</topic><topic>Orthomyxoviridae - immunology</topic><topic>Radiation Effects</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptors, Drug</topic><topic>Spleen - cytology</topic><topic>Surface Properties</topic><topic>T-Lymphocytes - immunology</topic><topic>Temperature</topic><topic>Time Factors</topic><topic>Ultraviolet Rays</topic><topic>Virus Replication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Woodruff, Judith J</creatorcontrib><creatorcontrib>Woodruff, Jack F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Woodruff, Judith J</au><au>Woodruff, Jack F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influenza A Virus Interaction with Murine Lymphocytes: I. The Influence of Influenza Virus A/Japan 305 (H2N2) on the Pattern of Migration of Recirculating Lymphocytes</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>1976-09</date><risdate>1976</risdate><volume>117</volume><issue>3</issue><spage>852</spage><pages>852-</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><abstract>The effect of influenza virus A/Japan 305 (H2N2) on the path of migration of recirculating lymphocytes has been studied. 51Cr-labeled rat thoracic duct lymphocytes (TDL) were incubated with virus at 37 degrees C for 1 hr and then infused i.v. into syngeneic recipients which were killed 1 hr later. Virus-treated TDL accumulated in the liver and their recovery in lymph nodes and spleen was severely reduced. Changes in lymphocytes induced by virus developed rapidly and were evident after incubation for only 15 min. UV-irradiated virus altered the pattern of lymphocyte localization but attachment of heat-inactivated virus to lymphocytes in vitro had no effect on their distribution in vivo. Evidence was obtained that some virus-treated TDL, initially sequestered in the liver, subsequently recovered their ability to circulate normally. Recovery was not complete and a population of cells failed to regain their ability to home into lymph nodes. Evidence is also presented demonstrating that influenza virus affected the homing properties of both T and B cells. It is suggested that aberrations in lymphocyte homing were mediated by the viral neuraminidase which induces changes in the cell membrane leading to their accumulation in the liver.</abstract><cop>United States</cop><pub>Am Assoc Immnol</pub><pmid>60451</pmid></addata></record> |
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subjects | alpha-Fetoproteins - pharmacology Animals B-Lymphocytes - immunology Cell Movement - drug effects Influenza A virus - enzymology Influenza A virus - immunology Influenza A virus - radiation effects Influenza A Virus, H2N2 Subtype Liver - cytology Lung - cytology Lymph Nodes - cytology Lymphocytes - immunology Neuraminidase - metabolism Orthomyxoviridae - immunology Radiation Effects Rats Rats, Inbred Strains Receptors, Drug Spleen - cytology Surface Properties T-Lymphocytes - immunology Temperature Time Factors Ultraviolet Rays Virus Replication |
title | Influenza A Virus Interaction with Murine Lymphocytes: I. The Influence of Influenza Virus A/Japan 305 (H2N2) on the Pattern of Migration of Recirculating Lymphocytes |
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