Influenza A Virus Interaction with Murine Lymphocytes: I. The Influence of Influenza Virus A/Japan 305 (H2N2) on the Pattern of Migration of Recirculating Lymphocytes

The effect of influenza virus A/Japan 305 (H2N2) on the path of migration of recirculating lymphocytes has been studied. 51Cr-labeled rat thoracic duct lymphocytes (TDL) were incubated with virus at 37 degrees C for 1 hr and then infused i.v. into syngeneic recipients which were killed 1 hr later. V...

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Veröffentlicht in:The Journal of immunology (1950) 1976-09, Vol.117 (3), p.852
Hauptverfasser: Woodruff, Judith J, Woodruff, Jack F
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Woodruff, Jack F
description The effect of influenza virus A/Japan 305 (H2N2) on the path of migration of recirculating lymphocytes has been studied. 51Cr-labeled rat thoracic duct lymphocytes (TDL) were incubated with virus at 37 degrees C for 1 hr and then infused i.v. into syngeneic recipients which were killed 1 hr later. Virus-treated TDL accumulated in the liver and their recovery in lymph nodes and spleen was severely reduced. Changes in lymphocytes induced by virus developed rapidly and were evident after incubation for only 15 min. UV-irradiated virus altered the pattern of lymphocyte localization but attachment of heat-inactivated virus to lymphocytes in vitro had no effect on their distribution in vivo. Evidence was obtained that some virus-treated TDL, initially sequestered in the liver, subsequently recovered their ability to circulate normally. Recovery was not complete and a population of cells failed to regain their ability to home into lymph nodes. Evidence is also presented demonstrating that influenza virus affected the homing properties of both T and B cells. It is suggested that aberrations in lymphocyte homing were mediated by the viral neuraminidase which induces changes in the cell membrane leading to their accumulation in the liver.
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UV-irradiated virus altered the pattern of lymphocyte localization but attachment of heat-inactivated virus to lymphocytes in vitro had no effect on their distribution in vivo. Evidence was obtained that some virus-treated TDL, initially sequestered in the liver, subsequently recovered their ability to circulate normally. Recovery was not complete and a population of cells failed to regain their ability to home into lymph nodes. Evidence is also presented demonstrating that influenza virus affected the homing properties of both T and B cells. 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The Influence of Influenza Virus A/Japan 305 (H2N2) on the Pattern of Migration of Recirculating Lymphocytes</title><title>The Journal of immunology (1950)</title><addtitle>J Immunol</addtitle><description>The effect of influenza virus A/Japan 305 (H2N2) on the path of migration of recirculating lymphocytes has been studied. 51Cr-labeled rat thoracic duct lymphocytes (TDL) were incubated with virus at 37 degrees C for 1 hr and then infused i.v. into syngeneic recipients which were killed 1 hr later. Virus-treated TDL accumulated in the liver and their recovery in lymph nodes and spleen was severely reduced. Changes in lymphocytes induced by virus developed rapidly and were evident after incubation for only 15 min. UV-irradiated virus altered the pattern of lymphocyte localization but attachment of heat-inactivated virus to lymphocytes in vitro had no effect on their distribution in vivo. Evidence was obtained that some virus-treated TDL, initially sequestered in the liver, subsequently recovered their ability to circulate normally. Recovery was not complete and a population of cells failed to regain their ability to home into lymph nodes. Evidence is also presented demonstrating that influenza virus affected the homing properties of both T and B cells. 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The Influence of Influenza Virus A/Japan 305 (H2N2) on the Pattern of Migration of Recirculating Lymphocytes</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>1976-09</date><risdate>1976</risdate><volume>117</volume><issue>3</issue><spage>852</spage><pages>852-</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><abstract>The effect of influenza virus A/Japan 305 (H2N2) on the path of migration of recirculating lymphocytes has been studied. 51Cr-labeled rat thoracic duct lymphocytes (TDL) were incubated with virus at 37 degrees C for 1 hr and then infused i.v. into syngeneic recipients which were killed 1 hr later. Virus-treated TDL accumulated in the liver and their recovery in lymph nodes and spleen was severely reduced. Changes in lymphocytes induced by virus developed rapidly and were evident after incubation for only 15 min. UV-irradiated virus altered the pattern of lymphocyte localization but attachment of heat-inactivated virus to lymphocytes in vitro had no effect on their distribution in vivo. Evidence was obtained that some virus-treated TDL, initially sequestered in the liver, subsequently recovered their ability to circulate normally. Recovery was not complete and a population of cells failed to regain their ability to home into lymph nodes. Evidence is also presented demonstrating that influenza virus affected the homing properties of both T and B cells. It is suggested that aberrations in lymphocyte homing were mediated by the viral neuraminidase which induces changes in the cell membrane leading to their accumulation in the liver.</abstract><cop>United States</cop><pub>Am Assoc Immnol</pub><pmid>60451</pmid></addata></record>
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source MEDLINE; Alma/SFX Local Collection
subjects alpha-Fetoproteins - pharmacology
Animals
B-Lymphocytes - immunology
Cell Movement - drug effects
Influenza A virus - enzymology
Influenza A virus - immunology
Influenza A virus - radiation effects
Influenza A Virus, H2N2 Subtype
Liver - cytology
Lung - cytology
Lymph Nodes - cytology
Lymphocytes - immunology
Neuraminidase - metabolism
Orthomyxoviridae - immunology
Radiation Effects
Rats
Rats, Inbred Strains
Receptors, Drug
Spleen - cytology
Surface Properties
T-Lymphocytes - immunology
Temperature
Time Factors
Ultraviolet Rays
Virus Replication
title Influenza A Virus Interaction with Murine Lymphocytes: I. The Influence of Influenza Virus A/Japan 305 (H2N2) on the Pattern of Migration of Recirculating Lymphocytes
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