Glomerulonephritis in Pressor Drug-Enhanced Serum Sickness of Rabbits.
Summary Repeated intravenous injections of blood pressure elevating drugs given shortly after a single large intravenous dose of horse serum markedly increased the incidence and severity of diffuse glomerulonephritis in rabbits sacrificed on the 11th day. Only minimal glomerular lesions were observe...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1965-12, Vol.120 (3), p.866-868 |
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| container_end_page | 868 |
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| container_issue | 3 |
| container_start_page | 866 |
| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 120 |
| creator | Wilens, Sigmund L. Henderson, Dolores |
| description | Summary
Repeated intravenous injections of blood pressure elevating drugs given shortly after a single large intravenous dose of horse serum markedly increased the incidence and severity of diffuse glomerulonephritis in rabbits sacrificed on the 11th day. Only minimal glomerular lesions were observed if the pressor agents were given at a later period. The implication of these findings is that these agents augment the development of renal damage in serum sickness when administered at a time when circulating antigen levels in the blood are high and that they may suppress this reaction when given at a time when antigen levels are rapidly falling and antibody levels rising. |
| doi_str_mv | 10.3181/00379727-120-30677 |
| format | Article |
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Repeated intravenous injections of blood pressure elevating drugs given shortly after a single large intravenous dose of horse serum markedly increased the incidence and severity of diffuse glomerulonephritis in rabbits sacrificed on the 11th day. Only minimal glomerular lesions were observed if the pressor agents were given at a later period. The implication of these findings is that these agents augment the development of renal damage in serum sickness when administered at a time when circulating antigen levels in the blood are high and that they may suppress this reaction when given at a time when antigen levels are rapidly falling and antibody levels rising.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-120-30677</identifier><identifier>PMID: 5858720</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Epinephrine - toxicity ; Glomerulonephritis - complications ; Metaraminol - toxicity ; Norepinephrine - toxicity ; Rabbits ; Serum Sickness - complications</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1965-12, Vol.120 (3), p.866-868</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c338t-784eac079dd057d129d6598fb3ba097ae4cc4ffb60f66e175ba6caa53156c4813</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5858720$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wilens, Sigmund L.</creatorcontrib><creatorcontrib>Henderson, Dolores</creatorcontrib><title>Glomerulonephritis in Pressor Drug-Enhanced Serum Sickness of Rabbits.</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Summary
Repeated intravenous injections of blood pressure elevating drugs given shortly after a single large intravenous dose of horse serum markedly increased the incidence and severity of diffuse glomerulonephritis in rabbits sacrificed on the 11th day. Only minimal glomerular lesions were observed if the pressor agents were given at a later period. The implication of these findings is that these agents augment the development of renal damage in serum sickness when administered at a time when circulating antigen levels in the blood are high and that they may suppress this reaction when given at a time when antigen levels are rapidly falling and antibody levels rising.</description><subject>Animals</subject><subject>Epinephrine - toxicity</subject><subject>Glomerulonephritis - complications</subject><subject>Metaraminol - toxicity</subject><subject>Norepinephrine - toxicity</subject><subject>Rabbits</subject><subject>Serum Sickness - complications</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1965</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1OAjEUhRujQURfwMSkL1Bop9O_pUFAExKN6LppOy0MMjOkZRa8vTOCLl3dxTnfSe4HwD3BY0okmWBMhRKZQCTDiGIuxAUYEkYZolypSzDsC6hvXIOblLYYEyYyPgADJpkUGR6C-WLXVD62u6b2-00sD2WCZQ3fok-pifAptms0qzemdr6Aq65YwVXpvuouhk2A78ba8pDGt-AqmF3yd-c7Ap_z2cf0GS1fFy_TxyVylMoDEjL3xmGhigIzUZBMFZwpGSy1BithfO5cHoLlOHDuiWDWcGcMo4Rxl0tCRyA77brYpBR90PtYViYeNcG6d6J_nejOif5x0kEPJ2jf2soXf8hZQpdPTnkya6-3TRvr7of_Fr8BgE9qPA</recordid><startdate>196512</startdate><enddate>196512</enddate><creator>Wilens, Sigmund L.</creator><creator>Henderson, Dolores</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>196512</creationdate><title>Glomerulonephritis in Pressor Drug-Enhanced Serum Sickness of Rabbits.</title><author>Wilens, Sigmund L. ; Henderson, Dolores</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-784eac079dd057d129d6598fb3ba097ae4cc4ffb60f66e175ba6caa53156c4813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1965</creationdate><topic>Animals</topic><topic>Epinephrine - toxicity</topic><topic>Glomerulonephritis - complications</topic><topic>Metaraminol - toxicity</topic><topic>Norepinephrine - toxicity</topic><topic>Rabbits</topic><topic>Serum Sickness - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wilens, Sigmund L.</creatorcontrib><creatorcontrib>Henderson, Dolores</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wilens, Sigmund L.</au><au>Henderson, Dolores</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glomerulonephritis in Pressor Drug-Enhanced Serum Sickness of Rabbits.</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1965-12</date><risdate>1965</risdate><volume>120</volume><issue>3</issue><spage>866</spage><epage>868</epage><pages>866-868</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary
Repeated intravenous injections of blood pressure elevating drugs given shortly after a single large intravenous dose of horse serum markedly increased the incidence and severity of diffuse glomerulonephritis in rabbits sacrificed on the 11th day. Only minimal glomerular lesions were observed if the pressor agents were given at a later period. The implication of these findings is that these agents augment the development of renal damage in serum sickness when administered at a time when circulating antigen levels in the blood are high and that they may suppress this reaction when given at a time when antigen levels are rapidly falling and antibody levels rising.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>5858720</pmid><doi>10.3181/00379727-120-30677</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1965-12, Vol.120 (3), p.866-868 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
| recordid | cdi_pubmed_primary_5858720 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Epinephrine - toxicity Glomerulonephritis - complications Metaraminol - toxicity Norepinephrine - toxicity Rabbits Serum Sickness - complications |
| title | Glomerulonephritis in Pressor Drug-Enhanced Serum Sickness of Rabbits. |
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