Positive Direct Coombs' Test Induced by Various Azo Dyes.
Summary In an earlier investigation the activity of the diazo dye trypan blue in producing an anemia with positive Coombs' test was attributed primarily to its capacity for binding with protein and thus either altering the surface of erythrocytes or serving as a prosthetic group for the attachm...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1965-08, Vol.119 (4), p.970-975 |
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| container_issue | 4 |
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| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 119 |
| creator | Norlind, Lorna M. Boehni, Eva M. Brown, David V. |
| description | Summary
In an earlier investigation the activity of the diazo dye trypan blue in producing an anemia with positive Coombs' test was attributed primarily to its capacity for binding with protein and thus either altering the surface of erythrocytes or serving as a prosthetic group for the attachment of serum proteins. The present study of the activity of a number of structurally related compounds supports this hypothesis, for only those dyes which appeared in the serum in high concentration, with a large proportion of non-protein bound (free) dye, induced protein coating of the erythrocytes. In general, the active dyes had structural formulae similar to trypan blue and the diazo linkage, as well as the presence of the amino group, appeared to be essential. |
| doi_str_mv | 10.3181/00379727-119-30352 |
| format | Article |
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In an earlier investigation the activity of the diazo dye trypan blue in producing an anemia with positive Coombs' test was attributed primarily to its capacity for binding with protein and thus either altering the surface of erythrocytes or serving as a prosthetic group for the attachment of serum proteins. The present study of the activity of a number of structurally related compounds supports this hypothesis, for only those dyes which appeared in the serum in high concentration, with a large proportion of non-protein bound (free) dye, induced protein coating of the erythrocytes. In general, the active dyes had structural formulae similar to trypan blue and the diazo linkage, as well as the presence of the amino group, appeared to be essential.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-119-30352</identifier><identifier>PMID: 5836050</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Anemia - etiology ; Animals ; Azo Compounds - toxicity ; Blood Proteins ; Coombs Test ; Rats ; Trypan Blue - toxicity</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1965-08, Vol.119 (4), p.970-975</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5836050$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Norlind, Lorna M.</creatorcontrib><creatorcontrib>Boehni, Eva M.</creatorcontrib><creatorcontrib>Brown, David V.</creatorcontrib><title>Positive Direct Coombs' Test Induced by Various Azo Dyes.</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Summary
In an earlier investigation the activity of the diazo dye trypan blue in producing an anemia with positive Coombs' test was attributed primarily to its capacity for binding with protein and thus either altering the surface of erythrocytes or serving as a prosthetic group for the attachment of serum proteins. The present study of the activity of a number of structurally related compounds supports this hypothesis, for only those dyes which appeared in the serum in high concentration, with a large proportion of non-protein bound (free) dye, induced protein coating of the erythrocytes. In general, the active dyes had structural formulae similar to trypan blue and the diazo linkage, as well as the presence of the amino group, appeared to be essential.</description><subject>Anemia - etiology</subject><subject>Animals</subject><subject>Azo Compounds - toxicity</subject><subject>Blood Proteins</subject><subject>Coombs Test</subject><subject>Rats</subject><subject>Trypan Blue - toxicity</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1965</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOAjEYhRujQURfwMSkO1eF_i1tp0sCqCQkukC3TaftmCFCSTtjgk_vIOjS1VmcS3I-hG6BDjkUMKKUK62YIgCacMoFO0N9EFwQLrU-R_1DgBwSl-gq5zWlIBSTPdQTBZdU0D7SLzHXTf0Z8KxOwTV4GuOmzPd4FXKDF1vfuuBxucdvNtWxzXjyFfFsH_LwGl1U9iOHm5MO0OvDfDV9Isvnx8V0siSOaWiI9V6rsROOjSvwVDJXKO0DWDmWQUnrtK4qDbbQXJRWy8oX1lOAgjJagvR8gNhx16WYcwqV2aV6Y9PeADUHDOYXg-kwmB8MXenuWNq15Sb4v8rpd-ePjn6278GsY5u23Yf_Fr8BxSZkEg</recordid><startdate>196508</startdate><enddate>196508</enddate><creator>Norlind, Lorna M.</creator><creator>Boehni, Eva M.</creator><creator>Brown, David V.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>196508</creationdate><title>Positive Direct Coombs' Test Induced by Various Azo Dyes.</title><author>Norlind, Lorna M. ; Boehni, Eva M. ; Brown, David V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c291t-add974c5c24f1d062c879de1a646e76ac99ff91a8935ba96fd8ad0118020b16d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1965</creationdate><topic>Anemia - etiology</topic><topic>Animals</topic><topic>Azo Compounds - toxicity</topic><topic>Blood Proteins</topic><topic>Coombs Test</topic><topic>Rats</topic><topic>Trypan Blue - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Norlind, Lorna M.</creatorcontrib><creatorcontrib>Boehni, Eva M.</creatorcontrib><creatorcontrib>Brown, David V.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Norlind, Lorna M.</au><au>Boehni, Eva M.</au><au>Brown, David V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Positive Direct Coombs' Test Induced by Various Azo Dyes.</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1965-08</date><risdate>1965</risdate><volume>119</volume><issue>4</issue><spage>970</spage><epage>975</epage><pages>970-975</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary
In an earlier investigation the activity of the diazo dye trypan blue in producing an anemia with positive Coombs' test was attributed primarily to its capacity for binding with protein and thus either altering the surface of erythrocytes or serving as a prosthetic group for the attachment of serum proteins. The present study of the activity of a number of structurally related compounds supports this hypothesis, for only those dyes which appeared in the serum in high concentration, with a large proportion of non-protein bound (free) dye, induced protein coating of the erythrocytes. In general, the active dyes had structural formulae similar to trypan blue and the diazo linkage, as well as the presence of the amino group, appeared to be essential.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>5836050</pmid><doi>10.3181/00379727-119-30352</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1965-08, Vol.119 (4), p.970-975 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
| recordid | cdi_pubmed_primary_5836050 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Anemia - etiology Animals Azo Compounds - toxicity Blood Proteins Coombs Test Rats Trypan Blue - toxicity |
| title | Positive Direct Coombs' Test Induced by Various Azo Dyes. |
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