Domperidone in the treatment of postoperative vomiting: a double-blind multicenter study
Domperidone was compared with placebo in a multicenter double-blind study of 116 patients (15 to 80 years) with postoperative vomiting. After vomiting had occurred, the patients received either domperidone 10 mg or placebo IV. Patients were then followed for at least 6 hours or until a 2nd injection...
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| Veröffentlicht in: | Anesthesia and analgesia 1978-11, Vol.57 (6), p.700 |
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| container_issue | 6 |
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| container_title | Anesthesia and analgesia |
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| creator | Zegveld, C Knape, H Smits, J Belopavlovic, M Caron, D Gallant, J Stockman, A Boghaert, A |
| description | Domperidone was compared with placebo in a multicenter double-blind study of 116 patients (15 to 80 years) with postoperative vomiting. After vomiting had occurred, the patients received either domperidone 10 mg or placebo IV. Patients were then followed for at least 6 hours or until a 2nd injection of domperidone 10 mg from an open supply was needed. The period of time until an additional injection was registered and compared between the 2 treatment groups. Fifty-nine percent of the placebo patients needed a 2nd injection before the end of the 6-hour follow-up, compared with only 35% of the domperidone patients (p less than 0.05). When a 2nd injection was required, the time elapsed before it was needed was longer (p = 0.01) in the domperidone group (median 150 minutes) than in the placebo one (median 120 minutes). There were no significant side-effects. |
| format | Article |
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After vomiting had occurred, the patients received either domperidone 10 mg or placebo IV. Patients were then followed for at least 6 hours or until a 2nd injection of domperidone 10 mg from an open supply was needed. The period of time until an additional injection was registered and compared between the 2 treatment groups. Fifty-nine percent of the placebo patients needed a 2nd injection before the end of the 6-hour follow-up, compared with only 35% of the domperidone patients (p less than 0.05). When a 2nd injection was required, the time elapsed before it was needed was longer (p = 0.01) in the domperidone group (median 150 minutes) than in the placebo one (median 120 minutes). 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After vomiting had occurred, the patients received either domperidone 10 mg or placebo IV. Patients were then followed for at least 6 hours or until a 2nd injection of domperidone 10 mg from an open supply was needed. The period of time until an additional injection was registered and compared between the 2 treatment groups. Fifty-nine percent of the placebo patients needed a 2nd injection before the end of the 6-hour follow-up, compared with only 35% of the domperidone patients (p less than 0.05). When a 2nd injection was required, the time elapsed before it was needed was longer (p = 0.01) in the domperidone group (median 150 minutes) than in the placebo one (median 120 minutes). There were no significant side-effects.</description><subject>Antiemetics - administration & dosage</subject><subject>Antiemetics - adverse effects</subject><subject>Antiemetics - therapeutic use</subject><subject>Benzimidazoles - administration & dosage</subject><subject>Benzimidazoles - adverse effects</subject><subject>Benzimidazoles - therapeutic use</subject><subject>Dose-Response Relationship, Drug</subject><subject>Double-Blind Method</subject><subject>Drug Evaluation</subject><subject>Humans</subject><subject>Piperidines - administration & dosage</subject><subject>Piperidines - adverse effects</subject><subject>Piperidines - therapeutic use</subject><subject>Placebos</subject><subject>Postoperative Complications - prevention & control</subject><subject>Vomiting - prevention & control</subject><issn>0003-2999</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotT8lqAzEU86FbmvYPevAPDHiJt95KukKglwR6C3b83LqMx8bjCeTvO5BeJCQkgS7QghDCO2aMuUG34_g7S0q0vEZXQs6mWKCv55wK1OjzADgOuP0AbhVsSzA0nAMueWx5TtgWj4CPOcUWh-9HbLHPk-uhc30cPE5T3-Jh7kDFY5v86Q5dBtuPcP_PS7R7fdmu37vN59vH-mnTFcpI6w7USKMkOB1kICuuuVCBMkUcE0Eyyo2g3HIpFbGacuoNyBmICZoop1Z8iR7Ou2VyCfy-1JhsPe3PB_kfqGpLlA</recordid><startdate>197811</startdate><enddate>197811</enddate><creator>Zegveld, C</creator><creator>Knape, H</creator><creator>Smits, J</creator><creator>Belopavlovic, M</creator><creator>Caron, D</creator><creator>Gallant, J</creator><creator>Stockman, A</creator><creator>Boghaert, A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>197811</creationdate><title>Domperidone in the treatment of postoperative vomiting: a double-blind multicenter study</title><author>Zegveld, C ; Knape, H ; Smits, J ; Belopavlovic, M ; Caron, D ; Gallant, J ; Stockman, A ; Boghaert, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p120t-c196976eb8f6f0438357f1270b25f62139513a36670a8131d9e61d909f807b743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Antiemetics - administration & dosage</topic><topic>Antiemetics - adverse effects</topic><topic>Antiemetics - therapeutic use</topic><topic>Benzimidazoles - administration & dosage</topic><topic>Benzimidazoles - adverse effects</topic><topic>Benzimidazoles - therapeutic use</topic><topic>Dose-Response Relationship, Drug</topic><topic>Double-Blind Method</topic><topic>Drug Evaluation</topic><topic>Humans</topic><topic>Piperidines - administration & dosage</topic><topic>Piperidines - adverse effects</topic><topic>Piperidines - therapeutic use</topic><topic>Placebos</topic><topic>Postoperative Complications - prevention & control</topic><topic>Vomiting - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zegveld, C</creatorcontrib><creatorcontrib>Knape, H</creatorcontrib><creatorcontrib>Smits, J</creatorcontrib><creatorcontrib>Belopavlovic, M</creatorcontrib><creatorcontrib>Caron, D</creatorcontrib><creatorcontrib>Gallant, J</creatorcontrib><creatorcontrib>Stockman, A</creatorcontrib><creatorcontrib>Boghaert, A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Anesthesia and analgesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zegveld, C</au><au>Knape, H</au><au>Smits, J</au><au>Belopavlovic, M</au><au>Caron, D</au><au>Gallant, J</au><au>Stockman, A</au><au>Boghaert, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Domperidone in the treatment of postoperative vomiting: a double-blind multicenter study</atitle><jtitle>Anesthesia and analgesia</jtitle><addtitle>Anesth Analg</addtitle><date>1978-11</date><risdate>1978</risdate><volume>57</volume><issue>6</issue><spage>700</spage><pages>700-</pages><issn>0003-2999</issn><abstract>Domperidone was compared with placebo in a multicenter double-blind study of 116 patients (15 to 80 years) with postoperative vomiting. After vomiting had occurred, the patients received either domperidone 10 mg or placebo IV. Patients were then followed for at least 6 hours or until a 2nd injection of domperidone 10 mg from an open supply was needed. The period of time until an additional injection was registered and compared between the 2 treatment groups. Fifty-nine percent of the placebo patients needed a 2nd injection before the end of the 6-hour follow-up, compared with only 35% of the domperidone patients (p less than 0.05). When a 2nd injection was required, the time elapsed before it was needed was longer (p = 0.01) in the domperidone group (median 150 minutes) than in the placebo one (median 120 minutes). There were no significant side-effects.</abstract><cop>United States</cop><pmid>569995</pmid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-2999 |
| ispartof | Anesthesia and analgesia, 1978-11, Vol.57 (6), p.700 |
| issn | 0003-2999 |
| language | eng |
| recordid | cdi_pubmed_primary_569995 |
| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Ovid Autoload |
| subjects | Antiemetics - administration & dosage Antiemetics - adverse effects Antiemetics - therapeutic use Benzimidazoles - administration & dosage Benzimidazoles - adverse effects Benzimidazoles - therapeutic use Dose-Response Relationship, Drug Double-Blind Method Drug Evaluation Humans Piperidines - administration & dosage Piperidines - adverse effects Piperidines - therapeutic use Placebos Postoperative Complications - prevention & control Vomiting - prevention & control |
| title | Domperidone in the treatment of postoperative vomiting: a double-blind multicenter study |
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