Blood Lactic Acid in Rats and Men: Comparison of Normo- and Hypertensive Individuals
Summary Among rats from two strains with opposite genetic predisposition to experimental hypertension, lactic acid concentrations in the blood were equivalent. Lactic acid concentration could not be correlated with the presence or absence of overt hypertension. Blood lactic acid values in these rats...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1968-06, Vol.128 (2), p.476-480 |
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| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 128 |
| creator | Knudsen, Knud D. Dahl, Lewis K. Tassinari, Lorraine M. |
| description | Summary
Among rats from two strains with opposite genetic predisposition to experimental hypertension, lactic acid concentrations in the blood were equivalent. Lactic acid concentration could not be correlated with the presence or absence of overt hypertension. Blood lactic acid values in these rats were comparable to those in man. In confimation of reports by others, among humans the average blood lactic acid value of a small group of hypertensive patients was increased as compared with the average value of an appropriate control group. Lactic acid concentration in all samples increased when the blood was allowed to stand at room temperature. This increase was larger in rat blood than in human samples and, in man, it increased faster in hypertensive patients than in controls. It is proposed that these differences may reflect ion transport activity by the red cell, and that the difference between man and rat is related to the dissimilar surface-to-volume ratio of the cells. |
| doi_str_mv | 10.3181/00379727-128-33042 |
| format | Article |
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Among rats from two strains with opposite genetic predisposition to experimental hypertension, lactic acid concentrations in the blood were equivalent. Lactic acid concentration could not be correlated with the presence or absence of overt hypertension. Blood lactic acid values in these rats were comparable to those in man. In confimation of reports by others, among humans the average blood lactic acid value of a small group of hypertensive patients was increased as compared with the average value of an appropriate control group. Lactic acid concentration in all samples increased when the blood was allowed to stand at room temperature. This increase was larger in rat blood than in human samples and, in man, it increased faster in hypertensive patients than in controls. It is proposed that these differences may reflect ion transport activity by the red cell, and that the difference between man and rat is related to the dissimilar surface-to-volume ratio of the cells.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-128-33042</identifier><identifier>PMID: 5663258</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Blood Pressure ; Female ; Humans ; Hypertension - chemically induced ; Lactates - blood ; Male ; Rats ; Sodium Chloride</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1968-06, Vol.128 (2), p.476-480</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5663258$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Knudsen, Knud D.</creatorcontrib><creatorcontrib>Dahl, Lewis K.</creatorcontrib><creatorcontrib>Tassinari, Lorraine M.</creatorcontrib><title>Blood Lactic Acid in Rats and Men: Comparison of Normo- and Hypertensive Individuals</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Summary
Among rats from two strains with opposite genetic predisposition to experimental hypertension, lactic acid concentrations in the blood were equivalent. Lactic acid concentration could not be correlated with the presence or absence of overt hypertension. Blood lactic acid values in these rats were comparable to those in man. In confimation of reports by others, among humans the average blood lactic acid value of a small group of hypertensive patients was increased as compared with the average value of an appropriate control group. Lactic acid concentration in all samples increased when the blood was allowed to stand at room temperature. This increase was larger in rat blood than in human samples and, in man, it increased faster in hypertensive patients than in controls. It is proposed that these differences may reflect ion transport activity by the red cell, and that the difference between man and rat is related to the dissimilar surface-to-volume ratio of the cells.</description><subject>Animals</subject><subject>Blood Pressure</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension - chemically induced</subject><subject>Lactates - blood</subject><subject>Male</subject><subject>Rats</subject><subject>Sodium Chloride</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1968</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9j8lOwzAURS0EKqHwA0hI5gNMPcSOvSxVGaQgJARr68UDStUmVZwu-HsSUliyeot7z306CF0zeieYZgtKRWEKXhDGNRGC5vwEZUwKSYQy5hRlY4GMjXN0kdKGUiYLrmZoJpUSXOoM3d5v29bjElxfO7x0tcd1g9-gTxgaj19Cc4nOImxTuDreOfp4WL-vnkj5-vi8WpbEcW16InwFnjnIK618lZuoGJgcHEQevIxcDe-Aai-MCEYzlwP3IFmohKReRy7miE-7rmtT6kK0-67eQfdlGbWjrv3VtYOu_dEdoJsJ2h-qXfB_yNFvyBdTnuAz2E176JrB4b_Fb92sW6U</recordid><startdate>196806</startdate><enddate>196806</enddate><creator>Knudsen, Knud D.</creator><creator>Dahl, Lewis K.</creator><creator>Tassinari, Lorraine M.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>196806</creationdate><title>Blood Lactic Acid in Rats and Men</title><author>Knudsen, Knud D. ; Dahl, Lewis K. ; Tassinari, Lorraine M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c289t-3dbad1ca4b86db49f61a94acaf2ed5f26258a08d393e981c4a2da51eb350d8f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1968</creationdate><topic>Animals</topic><topic>Blood Pressure</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension - chemically induced</topic><topic>Lactates - blood</topic><topic>Male</topic><topic>Rats</topic><topic>Sodium Chloride</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Knudsen, Knud D.</creatorcontrib><creatorcontrib>Dahl, Lewis K.</creatorcontrib><creatorcontrib>Tassinari, Lorraine M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Knudsen, Knud D.</au><au>Dahl, Lewis K.</au><au>Tassinari, Lorraine M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blood Lactic Acid in Rats and Men: Comparison of Normo- and Hypertensive Individuals</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1968-06</date><risdate>1968</risdate><volume>128</volume><issue>2</issue><spage>476</spage><epage>480</epage><pages>476-480</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary
Among rats from two strains with opposite genetic predisposition to experimental hypertension, lactic acid concentrations in the blood were equivalent. Lactic acid concentration could not be correlated with the presence or absence of overt hypertension. Blood lactic acid values in these rats were comparable to those in man. In confimation of reports by others, among humans the average blood lactic acid value of a small group of hypertensive patients was increased as compared with the average value of an appropriate control group. Lactic acid concentration in all samples increased when the blood was allowed to stand at room temperature. This increase was larger in rat blood than in human samples and, in man, it increased faster in hypertensive patients than in controls. It is proposed that these differences may reflect ion transport activity by the red cell, and that the difference between man and rat is related to the dissimilar surface-to-volume ratio of the cells.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>5663258</pmid><doi>10.3181/00379727-128-33042</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1968-06, Vol.128 (2), p.476-480 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
| recordid | cdi_pubmed_primary_5663258 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Blood Pressure Female Humans Hypertension - chemically induced Lactates - blood Male Rats Sodium Chloride |
| title | Blood Lactic Acid in Rats and Men: Comparison of Normo- and Hypertensive Individuals |
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