The Distribution of Injected 32P in Transient Hyperammonemia in the Chick and Rat
Summary The distribution of injected 32P was studied in the mildly hyperammonemic chick and rat. Ammonia toxicity in the chick resulted in decreased accumulation of 32P in the tibia (p
Gespeichert in:
| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1971-03, Vol.136 (3), p.772-776 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 776 |
|---|---|
| container_issue | 3 |
| container_start_page | 772 |
| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 136 |
| creator | Chow, Kye-Wing Lengemann, Frederick W. Pond, Wilson G. |
| description | Summary
The distribution of injected 32P was studied in the mildly hyperammonemic chick and rat. Ammonia toxicity in the chick resulted in decreased accumulation of 32P in the tibia (p |
| doi_str_mv | 10.3181/00379727-136-35362 |
| format | Article |
| fullrecord | <record><control><sourceid>sage_cross</sourceid><recordid>TN_cdi_pubmed_primary_5555370</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.3181_00379727-136-35362</sage_id><sourcerecordid>10.3181_00379727-136-35362</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1852-47e6145d026d5811ac7604d796a2e01cf0cf4ad7897a3a161738e7d5fa15ed6c3</originalsourceid><addsrcrecordid>eNp9kMtOwzAQRS0EKqXwA0hI_gFTjx3byRKVRytV4qGwjlzboS7Eqex00b8noYUls5nFvWekOQhdA73lkMOUUq4KxRQBLgkXXLITNAbBBeGyKE7ReCiQoXGOLlLaUApCMTlCI9EPV3SMXsu1w_c-ddGvdp1vA25rvAgbZzpnMWcv2AdcRh2Sd6HD8_3WRd00bXCN10PW9fxs7c0n1sHiN91dorNafyV3ddwT9P74UM7mZPn8tJjdLYmBXDCSKSchE5YyaUUOoI2SNLOqkJo5Cqamps60VXmhNNcgQfHcKStqDcJZafgEscNdE9uUoqurbfSNjvsKaDXoqX71VL2e6kdPD90coO1u1Tj7hxx99Pn0kCf94apNu4uh_-G_i98IRGw9</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>The Distribution of Injected 32P in Transient Hyperammonemia in the Chick and Rat</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Chow, Kye-Wing ; Lengemann, Frederick W. ; Pond, Wilson G.</creator><creatorcontrib>Chow, Kye-Wing ; Lengemann, Frederick W. ; Pond, Wilson G.</creatorcontrib><description><![CDATA[Summary
The distribution of injected 32P was studied in the mildly hyperammonemic chick and rat. Ammonia toxicity in the chick resulted in decreased accumulation of 32P in the tibia (p<.001) and decreased level of labeling in the inorganic phosphate fraction of blood (p<.001). Toxicity in the rat also resulted in decreased accumulation of label in the tibia (p<.005), but increased incorporation in the liver (p<.005), kidney (p<.005), and urine (p<.001), indicating that injected ammonia probably converted inorganic phosphate into a form that was eventually treated by the body as a waste product. Changes in organic blood metabolites accompanying ammonia toxicity in the chick paralleled those described earlier for the rat and pig.
The results of this study represent the first direct evidence that low doses of ammonia administered to laboratory animals interfere with phospate metabolism.]]></description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-136-35362</identifier><identifier>PMID: 5555370</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Ammonia - blood ; Ammonia - toxicity ; Animals ; Blood Urea Nitrogen ; Carbohydrates - blood ; Carbonates ; Chickens ; Injections, Intraperitoneal ; Ketone Bodies - blood ; Kidney - analysis ; Liver - analysis ; Male ; Phosphates - analysis ; Phosphates - metabolism ; Phosphorus Isotopes ; Pyruvates - blood ; Rats ; Tibia - analysis</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1971-03, Vol.136 (3), p.772-776</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1852-47e6145d026d5811ac7604d796a2e01cf0cf4ad7897a3a161738e7d5fa15ed6c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5555370$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chow, Kye-Wing</creatorcontrib><creatorcontrib>Lengemann, Frederick W.</creatorcontrib><creatorcontrib>Pond, Wilson G.</creatorcontrib><title>The Distribution of Injected 32P in Transient Hyperammonemia in the Chick and Rat</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description><![CDATA[Summary
The distribution of injected 32P was studied in the mildly hyperammonemic chick and rat. Ammonia toxicity in the chick resulted in decreased accumulation of 32P in the tibia (p<.001) and decreased level of labeling in the inorganic phosphate fraction of blood (p<.001). Toxicity in the rat also resulted in decreased accumulation of label in the tibia (p<.005), but increased incorporation in the liver (p<.005), kidney (p<.005), and urine (p<.001), indicating that injected ammonia probably converted inorganic phosphate into a form that was eventually treated by the body as a waste product. Changes in organic blood metabolites accompanying ammonia toxicity in the chick paralleled those described earlier for the rat and pig.
The results of this study represent the first direct evidence that low doses of ammonia administered to laboratory animals interfere with phospate metabolism.]]></description><subject>Ammonia - blood</subject><subject>Ammonia - toxicity</subject><subject>Animals</subject><subject>Blood Urea Nitrogen</subject><subject>Carbohydrates - blood</subject><subject>Carbonates</subject><subject>Chickens</subject><subject>Injections, Intraperitoneal</subject><subject>Ketone Bodies - blood</subject><subject>Kidney - analysis</subject><subject>Liver - analysis</subject><subject>Male</subject><subject>Phosphates - analysis</subject><subject>Phosphates - metabolism</subject><subject>Phosphorus Isotopes</subject><subject>Pyruvates - blood</subject><subject>Rats</subject><subject>Tibia - analysis</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1971</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EKqXwA0hI_gFTjx3byRKVRytV4qGwjlzboS7Eqex00b8noYUls5nFvWekOQhdA73lkMOUUq4KxRQBLgkXXLITNAbBBeGyKE7ReCiQoXGOLlLaUApCMTlCI9EPV3SMXsu1w_c-ddGvdp1vA25rvAgbZzpnMWcv2AdcRh2Sd6HD8_3WRd00bXCN10PW9fxs7c0n1sHiN91dorNafyV3ddwT9P74UM7mZPn8tJjdLYmBXDCSKSchE5YyaUUOoI2SNLOqkJo5Cqamps60VXmhNNcgQfHcKStqDcJZafgEscNdE9uUoqurbfSNjvsKaDXoqX71VL2e6kdPD90coO1u1Tj7hxx99Pn0kCf94apNu4uh_-G_i98IRGw9</recordid><startdate>197103</startdate><enddate>197103</enddate><creator>Chow, Kye-Wing</creator><creator>Lengemann, Frederick W.</creator><creator>Pond, Wilson G.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>197103</creationdate><title>The Distribution of Injected 32P in Transient Hyperammonemia in the Chick and Rat</title><author>Chow, Kye-Wing ; Lengemann, Frederick W. ; Pond, Wilson G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1852-47e6145d026d5811ac7604d796a2e01cf0cf4ad7897a3a161738e7d5fa15ed6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1971</creationdate><topic>Ammonia - blood</topic><topic>Ammonia - toxicity</topic><topic>Animals</topic><topic>Blood Urea Nitrogen</topic><topic>Carbohydrates - blood</topic><topic>Carbonates</topic><topic>Chickens</topic><topic>Injections, Intraperitoneal</topic><topic>Ketone Bodies - blood</topic><topic>Kidney - analysis</topic><topic>Liver - analysis</topic><topic>Male</topic><topic>Phosphates - analysis</topic><topic>Phosphates - metabolism</topic><topic>Phosphorus Isotopes</topic><topic>Pyruvates - blood</topic><topic>Rats</topic><topic>Tibia - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chow, Kye-Wing</creatorcontrib><creatorcontrib>Lengemann, Frederick W.</creatorcontrib><creatorcontrib>Pond, Wilson G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chow, Kye-Wing</au><au>Lengemann, Frederick W.</au><au>Pond, Wilson G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Distribution of Injected 32P in Transient Hyperammonemia in the Chick and Rat</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1971-03</date><risdate>1971</risdate><volume>136</volume><issue>3</issue><spage>772</spage><epage>776</epage><pages>772-776</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract><![CDATA[Summary
The distribution of injected 32P was studied in the mildly hyperammonemic chick and rat. Ammonia toxicity in the chick resulted in decreased accumulation of 32P in the tibia (p<.001) and decreased level of labeling in the inorganic phosphate fraction of blood (p<.001). Toxicity in the rat also resulted in decreased accumulation of label in the tibia (p<.005), but increased incorporation in the liver (p<.005), kidney (p<.005), and urine (p<.001), indicating that injected ammonia probably converted inorganic phosphate into a form that was eventually treated by the body as a waste product. Changes in organic blood metabolites accompanying ammonia toxicity in the chick paralleled those described earlier for the rat and pig.
The results of this study represent the first direct evidence that low doses of ammonia administered to laboratory animals interfere with phospate metabolism.]]></abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>5555370</pmid><doi>10.3181/00379727-136-35362</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1971-03, Vol.136 (3), p.772-776 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
| recordid | cdi_pubmed_primary_5555370 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Ammonia - blood Ammonia - toxicity Animals Blood Urea Nitrogen Carbohydrates - blood Carbonates Chickens Injections, Intraperitoneal Ketone Bodies - blood Kidney - analysis Liver - analysis Male Phosphates - analysis Phosphates - metabolism Phosphorus Isotopes Pyruvates - blood Rats Tibia - analysis |
| title | The Distribution of Injected 32P in Transient Hyperammonemia in the Chick and Rat |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-14T21%3A29%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-sage_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Distribution%20of%20Injected%2032P%20in%20Transient%20Hyperammonemia%20in%20the%20Chick%20and%20Rat&rft.jtitle=Experimental%20biology%20and%20medicine%20(Maywood,%20N.J.)&rft.au=Chow,%20Kye-Wing&rft.date=1971-03&rft.volume=136&rft.issue=3&rft.spage=772&rft.epage=776&rft.pages=772-776&rft.issn=0037-9727&rft.eissn=1535-3699&rft_id=info:doi/10.3181/00379727-136-35362&rft_dat=%3Csage_cross%3E10.3181_00379727-136-35362%3C/sage_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/5555370&rft_sage_id=10.3181_00379727-136-35362&rfr_iscdi=true |