Evaluation of radiography and isotopic scintigraphy for detecting skeletal metastases in breast cancer
Experience with technetium-phosphate compounds for skeletal scintigraphy in patients with breast cancer was analysed. When tumours were 5 cm or less in diameter (T1-2N0-1M0) metastases were demonstrated by radiographs in 1-7% (2/114). However, when radiography did not demonstrate metastases, lesions...
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| Veröffentlicht in: | The Lancet (British edition) 1976-01, Vol.1 (7953), p.237 |
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| creator | Roberts, J G Gravelle, I H Baum, M Bligh, A S Leach, K G Hughes, L E |
| description | Experience with technetium-phosphate compounds for skeletal scintigraphy in patients with breast cancer was analysed. When tumours were 5 cm or less in diameter (T1-2N0-1M0) metastases were demonstrated by radiographs in 1-7% (2/114). However, when radiography did not demonstrate metastases, lesions were found by scintigraphy in 41-3% (19/46). When lesions demonstrated by scintigraphy at the same site as abnormalities regarded as "benign" by radiography were excluded, 23% (11/46) had scintigraphs strongly suggestive of metastases. It is proposed that routine radiographic skeletal survey for patients presenting with breast cancer be abandoned, and replaced by skeletal scintigraphy, chest radiography, and specific localised radiographs of lesions demonstrated by scintigraphy. It is suggested that with this policy the development of expertise in interpreting scintigraphs will be accelerated, the cost of pre-treatment assessment will be reduced, and clinical management rationalised. |
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When tumours were 5 cm or less in diameter (T1-2N0-1M0) metastases were demonstrated by radiographs in 1-7% (2/114). However, when radiography did not demonstrate metastases, lesions were found by scintigraphy in 41-3% (19/46). When lesions demonstrated by scintigraphy at the same site as abnormalities regarded as "benign" by radiography were excluded, 23% (11/46) had scintigraphs strongly suggestive of metastases. It is proposed that routine radiographic skeletal survey for patients presenting with breast cancer be abandoned, and replaced by skeletal scintigraphy, chest radiography, and specific localised radiographs of lesions demonstrated by scintigraphy. 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When tumours were 5 cm or less in diameter (T1-2N0-1M0) metastases were demonstrated by radiographs in 1-7% (2/114). However, when radiography did not demonstrate metastases, lesions were found by scintigraphy in 41-3% (19/46). When lesions demonstrated by scintigraphy at the same site as abnormalities regarded as "benign" by radiography were excluded, 23% (11/46) had scintigraphs strongly suggestive of metastases. It is proposed that routine radiographic skeletal survey for patients presenting with breast cancer be abandoned, and replaced by skeletal scintigraphy, chest radiography, and specific localised radiographs of lesions demonstrated by scintigraphy. 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| ispartof | The Lancet (British edition), 1976-01, Vol.1 (7953), p.237 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Bone Neoplasms - diagnosis Bone Neoplasms - diagnostic imaging Breast Neoplasms Evaluation Studies as Topic False Negative Reactions Female Humans Lung Neoplasms - diagnosis Lung Neoplasms - diagnostic imaging Neoplasm Metastasis - diagnosis Neoplasm Metastasis - diagnostic imaging Prospective Studies Radiography Radionuclide Imaging Retrospective Studies Technetium |
| title | Evaluation of radiography and isotopic scintigraphy for detecting skeletal metastases in breast cancer |
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