Philadelphia Chromosome in Acute Lymphocytic Leukemia
It is recognized that the Ph1 chromosome anomaly is characteristic of chronic granulocytic leukemia. It has been shown however, to occur rarely in other myeloproliferative diseases. We have reported a 53-year-old roentgenologist with acute lymphocytic leukemia who showed a high percentage of Ph1 chr...
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| Veröffentlicht in: | Blood 1970-09, Vol.36 (3), p.353-360 |
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| container_title | Blood |
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| creator | Propp, Simon Lizzi, Frank A. |
| description | It is recognized that the Ph1 chromosome anomaly is characteristic of chronic granulocytic leukemia. It has been shown however, to occur rarely in other myeloproliferative diseases. We have reported a 53-year-old roentgenologist with acute lymphocytic leukemia who showed a high percentage of Ph1 chromosomes in his marrow cells. The possible role of radiation exposure in the production of the abnormal chromosome in this patient is discussed. The data presented is evidence against the specificity of the Ph1 chromosome for myeloproliferative disorders. |
| doi_str_mv | 10.1182/blood.V36.3.353.353 |
| format | Article |
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It has been shown however, to occur rarely in other myeloproliferative diseases. We have reported a 53-year-old roentgenologist with acute lymphocytic leukemia who showed a high percentage of Ph1 chromosomes in his marrow cells. The possible role of radiation exposure in the production of the abnormal chromosome in this patient is discussed. The data presented is evidence against the specificity of the Ph1 chromosome for myeloproliferative disorders.</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood.V36.3.353.353</identifier><identifier>PMID: 5271290</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Bone Marrow Examination ; Chromosome Aberrations ; Humans ; Karyotyping ; Leukemia, Lymphoid - blood ; Leukemia, Lymphoid - drug therapy ; Leukemia, Lymphoid - genetics ; Male ; Mercaptopurine - therapeutic use ; Middle Aged ; Prednisone - therapeutic use ; Radiation Injuries</subject><ispartof>Blood, 1970-09, Vol.36 (3), p.353-360</ispartof><rights>1970 American Society of Hematology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5271290$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Propp, Simon</creatorcontrib><creatorcontrib>Lizzi, Frank A.</creatorcontrib><title>Philadelphia Chromosome in Acute Lymphocytic Leukemia</title><title>Blood</title><addtitle>Blood</addtitle><description>It is recognized that the Ph1 chromosome anomaly is characteristic of chronic granulocytic leukemia. It has been shown however, to occur rarely in other myeloproliferative diseases. We have reported a 53-year-old roentgenologist with acute lymphocytic leukemia who showed a high percentage of Ph1 chromosomes in his marrow cells. The possible role of radiation exposure in the production of the abnormal chromosome in this patient is discussed. The data presented is evidence against the specificity of the Ph1 chromosome for myeloproliferative disorders.</description><subject>Bone Marrow Examination</subject><subject>Chromosome Aberrations</subject><subject>Humans</subject><subject>Karyotyping</subject><subject>Leukemia, Lymphoid - blood</subject><subject>Leukemia, Lymphoid - drug therapy</subject><subject>Leukemia, Lymphoid - genetics</subject><subject>Male</subject><subject>Mercaptopurine - therapeutic use</subject><subject>Middle Aged</subject><subject>Prednisone - therapeutic use</subject><subject>Radiation Injuries</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1970</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotkM1KxDAUhYMo4zj6BCL0BVpvcps2WbgYBkeFgi7UbUibOzTaTkrbEebt7fwsPs7iwOHwMXbPIeFciceyCcEl35glmKA8csHmXAoVAwi4ZHMAyOJU5_ya3QzDDwBPUcgZm0mRc6FhzuRH7RvrqOlqb6NV3Yc2DKGlyG-jZbUbKSr2bVeHaj_6Kipo90utt7fsamObge7OuWBf6-fP1WtcvL-8rZZFTCKDMS5JOSVL0kCcUyk3VmkkC7kSKcJGWw6CS4l5BiRSjWhRkrbKgUOb5ogL9nDa7XZlS850vW9tvzfn-1P_dOppOvHnqTdD5WlbkfM9VaNxwRsO5mDLHG2ZyZZBM5k6gP8qG1wo</recordid><startdate>197009</startdate><enddate>197009</enddate><creator>Propp, Simon</creator><creator>Lizzi, Frank A.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>197009</creationdate><title>Philadelphia Chromosome in Acute Lymphocytic Leukemia</title><author>Propp, Simon ; Lizzi, Frank A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e260t-be8d85be90e11eb5fa893ea0782430f9a1021553760e24933a35e9a8d0d3a4733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1970</creationdate><topic>Bone Marrow Examination</topic><topic>Chromosome Aberrations</topic><topic>Humans</topic><topic>Karyotyping</topic><topic>Leukemia, Lymphoid - blood</topic><topic>Leukemia, Lymphoid - drug therapy</topic><topic>Leukemia, Lymphoid - genetics</topic><topic>Male</topic><topic>Mercaptopurine - therapeutic use</topic><topic>Middle Aged</topic><topic>Prednisone - therapeutic use</topic><topic>Radiation Injuries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Propp, Simon</creatorcontrib><creatorcontrib>Lizzi, Frank A.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Propp, Simon</au><au>Lizzi, Frank A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Philadelphia Chromosome in Acute Lymphocytic Leukemia</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>1970-09</date><risdate>1970</risdate><volume>36</volume><issue>3</issue><spage>353</spage><epage>360</epage><pages>353-360</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>It is recognized that the Ph1 chromosome anomaly is characteristic of chronic granulocytic leukemia. 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| ispartof | Blood, 1970-09, Vol.36 (3), p.353-360 |
| issn | 0006-4971 1528-0020 |
| language | eng |
| recordid | cdi_pubmed_primary_5271290 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Bone Marrow Examination Chromosome Aberrations Humans Karyotyping Leukemia, Lymphoid - blood Leukemia, Lymphoid - drug therapy Leukemia, Lymphoid - genetics Male Mercaptopurine - therapeutic use Middle Aged Prednisone - therapeutic use Radiation Injuries |
| title | Philadelphia Chromosome in Acute Lymphocytic Leukemia |
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