Induction of the polyamine-biosynthetic enzymes in mouse epidermis by tumor-promoting agents

A single topical application of 1.0 mg of crotol oil or 17 nmoles of 12-O-tetradecanoyl-phorbol-13-acetate (TPA) resulted in a rapid, transient stimulation of mouse epidermal ornithine decarboxylase activity. The activity reached a peak (230-fold greater than control after TPA) at 4 to 5 hr after cr...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1975-07, Vol.35 (7), p.1662
Hauptverfasser:	O'Brien, T G, Simsiman, R C, Boutwell, R K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosylmethionine Decarboxylase - biosynthesis Animals Azacitidine - pharmacology Carboxy-Lyases - biosynthesis Carcinogens - pharmacology Chick Embryo Croton Oil - pharmacology Cycloheximide - pharmacology Dactinomycin - pharmacology Deoxyadenosines - pharmacology Dose-Response Relationship, Drug Enzyme Induction Female Half-Life Mice Ornithine Decarboxylase - biosynthesis Phorbols - pharmacology RNA - biosynthesis Skin - enzymology Time Factors
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