Tumors of the Esophagus and Duodenum Induced in Mice by Oral Adm.inistration of N-Ethyl-N′-Nitro-N-Nitrosoguanidine

N-Ethyl-N′-nitro-N-nitrosoguanidine (ENNG) fed in drinking water to CBA/H-T6 mice produced squamous cell carcinomas of the esophagus and adenocarcinomas of the duodenum in about one-third of the animals over a period of 355–540 days. Many of the tumors invaded the adjacent organs.

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 1974-02, Vol.52 (2), p.519-522
Hauptverfasser:	Nakamura, Takaaki, Matsuyama, Mutsushi, Kishimoto, Hidemasa
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Carcinoma, Squamous Cell - chemically induced Duodenal Neoplasms - chemically induced Esophageal Neoplasms - chemically induced Female Male Mice Mice, Inbred CBA Neoplasm Metastasis Neoplasms, Experimental - chemically induced Nitrosoguanidines Stomach Neoplasms - chemically induced Time Factors
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Beschreibung
Zusammenfassung:	N-Ethyl-N′-nitro-N-nitrosoguanidine (ENNG) fed in drinking water to CBA/H-T6 mice produced squamous cell carcinomas of the esophagus and adenocarcinomas of the duodenum in about one-third of the animals over a period of 355–540 days. Many of the tumors invaded the adjacent organs.
ISSN:	0027-8874 1460-2105
DOI:	10.1093/jnci/52.2.519