Measurement Of Systemic Inflammatory Activity In Rheumatoid Arthritis By The 99mTc Method
From the Department of Medicine, and the Isotope Laboratory, Central Hospital, Jyväskylä, Finland A radioisotope method consisting of measurements of 99mTc accumulation above a large joint area was used to study systemic inflammatory activity of rheumatoid arthritis. The results were expressed as an...
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| Veröffentlicht in: | Scandinavian journal of rheumatology 1973, Vol.2 (3), p.101-107 |
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| container_title | Scandinavian journal of rheumatology |
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| creator | Oka, Martti Rekonen, Ahti Ruotsi, Ahti Kuikka, Jyrki |
| description | From the Department of Medicine, and the Isotope Laboratory, Central Hospital, Jyväskylä, Finland
A radioisotope method consisting of measurements of 99mTc accumulation above a large joint area was used to study systemic inflammatory activity of rheumatoid arthritis. The results were expressed as an activity index using the heart and urinary bladder as reference points. The Tc index was significantly higher in the rheumatoid arthritis patients than in the controls but there was a marked overlapping in cases with slight disease activity. The Tc index was significantly correlated with ESR, fatigue, duration of morning stiffness, grip strength and Lansbury's systemic index. No correlation was found with haemoglobin, acetylsalicylic acid requirement, Waaler-Rose titre or duration of disease. The Tc index was used with success to demonstrate the change in joint inflammation during short-term administration of oral prednisolone. The test was also used in a double-blind trial of an anthranilic acid derivative, tolfenamic acid. No effect could be shown. The effect of prolonged gold-salt treatment was reflected in the Tc index. We conclude that the Tc index can be used as an objective measure of rheumatoid disease activity. The measurement is based on increased blood supply and enhanced transport of 99mTc to the inflamed synovium.
Read at the VII European Rheumatology Congress at Brighton, England, in June, 1971.
Martti Oka Department of Medicine Central Hospital Jyväskylä Finland |
| doi_str_mv | 10.3109/03009747309098826 |
| format | Article |
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A radioisotope method consisting of measurements of 99mTc accumulation above a large joint area was used to study systemic inflammatory activity of rheumatoid arthritis. The results were expressed as an activity index using the heart and urinary bladder as reference points. The Tc index was significantly higher in the rheumatoid arthritis patients than in the controls but there was a marked overlapping in cases with slight disease activity. The Tc index was significantly correlated with ESR, fatigue, duration of morning stiffness, grip strength and Lansbury's systemic index. No correlation was found with haemoglobin, acetylsalicylic acid requirement, Waaler-Rose titre or duration of disease. The Tc index was used with success to demonstrate the change in joint inflammation during short-term administration of oral prednisolone. The test was also used in a double-blind trial of an anthranilic acid derivative, tolfenamic acid. No effect could be shown. The effect of prolonged gold-salt treatment was reflected in the Tc index. We conclude that the Tc index can be used as an objective measure of rheumatoid disease activity. The measurement is based on increased blood supply and enhanced transport of 99mTc to the inflamed synovium.
Read at the VII European Rheumatology Congress at Brighton, England, in June, 1971.
Martti Oka Department of Medicine Central Hospital Jyväskylä Finland</description><identifier>ISSN: 0300-9742</identifier><identifier>EISSN: 1502-7732</identifier><identifier>DOI: 10.3109/03009747309098826</identifier><identifier>PMID: 4769061</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Adult ; Aged ; Arthritis, Rheumatoid - complications ; Arthritis, Rheumatoid - drug therapy ; Arthritis, Rheumatoid - physiopathology ; Aspirin - therapeutic use ; Biomechanical Phenomena ; Blood Sedimentation ; Depression, Chemical ; Fatigue ; Female ; Gold - therapeutic use ; Hemoglobins - analysis ; Humans ; Male ; Methods ; Middle Aged ; ortho-Aminobenzoates - therapeutic use ; Periarthritis ; Prednisolone - therapeutic use ; Radioisotopes ; Rheumatoid Factor ; Technetium ; Time Factors ; Toluene - therapeutic use</subject><ispartof>Scandinavian journal of rheumatology, 1973, Vol.2 (3), p.101-107</ispartof><rights>1973 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1973</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/03009747309098826$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/03009747309098826$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4769061$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oka, Martti</creatorcontrib><creatorcontrib>Rekonen, Ahti</creatorcontrib><creatorcontrib>Ruotsi, Ahti</creatorcontrib><creatorcontrib>Kuikka, Jyrki</creatorcontrib><title>Measurement Of Systemic Inflammatory Activity In Rheumatoid Arthritis By The 99mTc Method</title><title>Scandinavian journal of rheumatology</title><addtitle>Scand J Rheumatol</addtitle><description>From the Department of Medicine, and the Isotope Laboratory, Central Hospital, Jyväskylä, Finland
A radioisotope method consisting of measurements of 99mTc accumulation above a large joint area was used to study systemic inflammatory activity of rheumatoid arthritis. The results were expressed as an activity index using the heart and urinary bladder as reference points. The Tc index was significantly higher in the rheumatoid arthritis patients than in the controls but there was a marked overlapping in cases with slight disease activity. The Tc index was significantly correlated with ESR, fatigue, duration of morning stiffness, grip strength and Lansbury's systemic index. No correlation was found with haemoglobin, acetylsalicylic acid requirement, Waaler-Rose titre or duration of disease. The Tc index was used with success to demonstrate the change in joint inflammation during short-term administration of oral prednisolone. The test was also used in a double-blind trial of an anthranilic acid derivative, tolfenamic acid. No effect could be shown. The effect of prolonged gold-salt treatment was reflected in the Tc index. We conclude that the Tc index can be used as an objective measure of rheumatoid disease activity. The measurement is based on increased blood supply and enhanced transport of 99mTc to the inflamed synovium.
Read at the VII European Rheumatology Congress at Brighton, England, in June, 1971.
Martti Oka Department of Medicine Central Hospital Jyväskylä Finland</description><subject>Adult</subject><subject>Aged</subject><subject>Arthritis, Rheumatoid - complications</subject><subject>Arthritis, Rheumatoid - drug therapy</subject><subject>Arthritis, Rheumatoid - physiopathology</subject><subject>Aspirin - therapeutic use</subject><subject>Biomechanical Phenomena</subject><subject>Blood Sedimentation</subject><subject>Depression, Chemical</subject><subject>Fatigue</subject><subject>Female</subject><subject>Gold - therapeutic use</subject><subject>Hemoglobins - analysis</subject><subject>Humans</subject><subject>Male</subject><subject>Methods</subject><subject>Middle Aged</subject><subject>ortho-Aminobenzoates - therapeutic use</subject><subject>Periarthritis</subject><subject>Prednisolone - therapeutic use</subject><subject>Radioisotopes</subject><subject>Rheumatoid Factor</subject><subject>Technetium</subject><subject>Time Factors</subject><subject>Toluene - therapeutic use</subject><issn>0300-9742</issn><issn>1502-7732</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1rFTEUhoMo9Vr9AS6ErNyNniSTZIJursWPQktBrwtXIU1OmJT5qElGmX_vXHo3Ii4OL7wfZ_EQ8pLBG8HAvAUBYHSrBRgwXcfVI7JjEnijteCPye6YN1uBPyXPSrkDgNZoc0bOWq0MKLYjP67RlSXjiFOlN5F-W0vFMXl6OcXBjaOrc17p3tf0K9V1c-nXHpejnQLd59rnVFOhH1Z66JEaMx48vcbaz-E5eRLdUPDFSc_J908fDxdfmqubz5cX-6smMdmxRqKKEjQPIXJEBWgEBqY6CLxTmmknfFCqFbHFKB0oz2-FjB6cbI004MQ5ef3w9z7PPxcs1Y6peBwGN-G8FNtxJqTq2q346lRcbkcM9j6n0eXVnlhs-fuHPE1xzqP7Pech2OrWYc4xu8mnYjfqxzP2H_Lb_N1f8x7dUHvvMtq7ecnTxsD-f_0Hz9eGBg</recordid><startdate>1973</startdate><enddate>1973</enddate><creator>Oka, Martti</creator><creator>Rekonen, Ahti</creator><creator>Ruotsi, Ahti</creator><creator>Kuikka, Jyrki</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>1973</creationdate><title>Measurement Of Systemic Inflammatory Activity In Rheumatoid Arthritis By The 99mTc Method</title><author>Oka, Martti ; Rekonen, Ahti ; Ruotsi, Ahti ; Kuikka, Jyrki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i1581-5e6f5072ddf2ee60e93ed1680d286717a3cd6643f4ef5a06c2b35fc0a549590a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Arthritis, Rheumatoid - complications</topic><topic>Arthritis, Rheumatoid - drug therapy</topic><topic>Arthritis, Rheumatoid - physiopathology</topic><topic>Aspirin - therapeutic use</topic><topic>Biomechanical Phenomena</topic><topic>Blood Sedimentation</topic><topic>Depression, Chemical</topic><topic>Fatigue</topic><topic>Female</topic><topic>Gold - therapeutic use</topic><topic>Hemoglobins - analysis</topic><topic>Humans</topic><topic>Male</topic><topic>Methods</topic><topic>Middle Aged</topic><topic>ortho-Aminobenzoates - therapeutic use</topic><topic>Periarthritis</topic><topic>Prednisolone - therapeutic use</topic><topic>Radioisotopes</topic><topic>Rheumatoid Factor</topic><topic>Technetium</topic><topic>Time Factors</topic><topic>Toluene - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oka, Martti</creatorcontrib><creatorcontrib>Rekonen, Ahti</creatorcontrib><creatorcontrib>Ruotsi, Ahti</creatorcontrib><creatorcontrib>Kuikka, Jyrki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oka, Martti</au><au>Rekonen, Ahti</au><au>Ruotsi, Ahti</au><au>Kuikka, Jyrki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Measurement Of Systemic Inflammatory Activity In Rheumatoid Arthritis By The 99mTc Method</atitle><jtitle>Scandinavian journal of rheumatology</jtitle><addtitle>Scand J Rheumatol</addtitle><date>1973</date><risdate>1973</risdate><volume>2</volume><issue>3</issue><spage>101</spage><epage>107</epage><pages>101-107</pages><issn>0300-9742</issn><eissn>1502-7732</eissn><abstract>From the Department of Medicine, and the Isotope Laboratory, Central Hospital, Jyväskylä, Finland
A radioisotope method consisting of measurements of 99mTc accumulation above a large joint area was used to study systemic inflammatory activity of rheumatoid arthritis. The results were expressed as an activity index using the heart and urinary bladder as reference points. The Tc index was significantly higher in the rheumatoid arthritis patients than in the controls but there was a marked overlapping in cases with slight disease activity. The Tc index was significantly correlated with ESR, fatigue, duration of morning stiffness, grip strength and Lansbury's systemic index. No correlation was found with haemoglobin, acetylsalicylic acid requirement, Waaler-Rose titre or duration of disease. The Tc index was used with success to demonstrate the change in joint inflammation during short-term administration of oral prednisolone. The test was also used in a double-blind trial of an anthranilic acid derivative, tolfenamic acid. No effect could be shown. The effect of prolonged gold-salt treatment was reflected in the Tc index. We conclude that the Tc index can be used as an objective measure of rheumatoid disease activity. The measurement is based on increased blood supply and enhanced transport of 99mTc to the inflamed synovium.
Read at the VII European Rheumatology Congress at Brighton, England, in June, 1971.
Martti Oka Department of Medicine Central Hospital Jyväskylä Finland</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>4769061</pmid><doi>10.3109/03009747309098826</doi><tpages>7</tpages></addata></record> |
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| ispartof | Scandinavian journal of rheumatology, 1973, Vol.2 (3), p.101-107 |
| issn | 0300-9742 1502-7732 |
| language | eng |
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| source | MEDLINE; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | Adult Aged Arthritis, Rheumatoid - complications Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - physiopathology Aspirin - therapeutic use Biomechanical Phenomena Blood Sedimentation Depression, Chemical Fatigue Female Gold - therapeutic use Hemoglobins - analysis Humans Male Methods Middle Aged ortho-Aminobenzoates - therapeutic use Periarthritis Prednisolone - therapeutic use Radioisotopes Rheumatoid Factor Technetium Time Factors Toluene - therapeutic use |
| title | Measurement Of Systemic Inflammatory Activity In Rheumatoid Arthritis By The 99mTc Method |
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