Experimental warfarin poisoning in the dog: Platelet function, coagulation and fibrinolysis
Experimental warfarin poisoning in dogs produced a profound haemostatic defect with depression in the levels of factors II, VII, IX and X and gross prolongation of the bleeding time. Surprisingly platelet function was unaltered suggesting that in the dog the intrinsic coagulation pathway plays an im...
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| Veröffentlicht in: | Journal of comparative pathology 1973-01, Vol.83 (2), p.173-180 |
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| container_end_page | 180 |
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| container_issue | 2 |
| container_start_page | 173 |
| container_title | Journal of comparative pathology |
| container_volume | 83 |
| creator | Forbes, C.D. Thomson, C. Prentice, C.R.M. McNicol, G.P. McEwan, A.D. |
| description | Experimental warfarin poisoning in dogs produced a profound haemostatic defect with depression in the levels of factors II, VII, IX and X and gross prolongation of the bleeding time. Surprisingly platelet function was unaltered suggesting that in the dog the intrinsic coagulation pathway plays an important part in the normal bleeding time. There was slight shortening of the euglobulin lysis time, but no other changes in the components of the fibrinolytic enzyme system. Rapid reversal of the clotting abnormality was produced by the intravenous injection of vitamin K
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| doi_str_mv | 10.1016/0021-9975(73)90040-6 |
| format | Article |
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1.</description><identifier>ISSN: 0021-9975</identifier><identifier>EISSN: 1532-3129</identifier><identifier>DOI: 10.1016/0021-9975(73)90040-6</identifier><identifier>PMID: 4761660</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>animal health ; animal injuries ; Animals ; Blood Coagulation - drug effects ; Blood Coagulation Tests ; Blood Platelets - drug effects ; Dogs ; Factor IX ; Factor VII ; Factor X ; Female ; Fibrinolysis - drug effects ; Hemostasis ; Kaolin ; Male ; Phosphatidylethanolamines ; Platelet Adhesiveness ; Prothrombin ; Prothrombin Time ; Serum Globulins ; Thrombin ; Time Factors ; Urea - blood ; Vitamin K - therapeutic use ; Warfarin - toxicity</subject><ispartof>Journal of comparative pathology, 1973-01, Vol.83 (2), p.173-180</ispartof><rights>1973</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0021-9975(73)90040-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4761660$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Forbes, C.D.</creatorcontrib><creatorcontrib>Thomson, C.</creatorcontrib><creatorcontrib>Prentice, C.R.M.</creatorcontrib><creatorcontrib>McNicol, G.P.</creatorcontrib><creatorcontrib>McEwan, A.D.</creatorcontrib><title>Experimental warfarin poisoning in the dog: Platelet function, coagulation and fibrinolysis</title><title>Journal of comparative pathology</title><addtitle>J Comp Pathol</addtitle><description>Experimental warfarin poisoning in dogs produced a profound haemostatic defect with depression in the levels of factors II, VII, IX and X and gross prolongation of the bleeding time. Surprisingly platelet function was unaltered suggesting that in the dog the intrinsic coagulation pathway plays an important part in the normal bleeding time. There was slight shortening of the euglobulin lysis time, but no other changes in the components of the fibrinolytic enzyme system. Rapid reversal of the clotting abnormality was produced by the intravenous injection of vitamin K
1.</description><subject>animal health</subject><subject>animal injuries</subject><subject>Animals</subject><subject>Blood Coagulation - drug effects</subject><subject>Blood Coagulation Tests</subject><subject>Blood Platelets - drug effects</subject><subject>Dogs</subject><subject>Factor IX</subject><subject>Factor VII</subject><subject>Factor X</subject><subject>Female</subject><subject>Fibrinolysis - drug effects</subject><subject>Hemostasis</subject><subject>Kaolin</subject><subject>Male</subject><subject>Phosphatidylethanolamines</subject><subject>Platelet Adhesiveness</subject><subject>Prothrombin</subject><subject>Prothrombin Time</subject><subject>Serum Globulins</subject><subject>Thrombin</subject><subject>Time Factors</subject><subject>Urea - blood</subject><subject>Vitamin K - therapeutic use</subject><subject>Warfarin - toxicity</subject><issn>0021-9975</issn><issn>1532-3129</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UE1LxDAQDaKs6-o_UMxRweokadLUgyDL-gELCronDyFtpzVS09J21f33Zt3Fywxv5r35eIQcM7hkwNQVAGdRmibyLBHnKUAMkdohYyYFjwTj6S4Z_1P2yUHffwCA1pKPyChOFFMKxuRt9tNi5z7RD7am37Yrbec8bRvXN975igYwvCMtmuqaPtd2wBoHWi59PrjGX9C8sdUylAOg1he0dFnQN_Wqd_0h2Stt3ePRNk_I4m72On2I5k_3j9PbeYRcyyFKtOaljrM4znia52khklwwjFkqJGDJUUohBWjUKlEiRItQChUHsUWWcTEhJ5u57TL7xMK04R_brcz2ydA_3fRL2xhbda43ixcOTIDgYYtmgXGzYWA488thZ_rcoc-xcB3mgykaZxiYte1m7alZe2oSYf5sN0r8AgOiccA</recordid><startdate>19730101</startdate><enddate>19730101</enddate><creator>Forbes, C.D.</creator><creator>Thomson, C.</creator><creator>Prentice, C.R.M.</creator><creator>McNicol, G.P.</creator><creator>McEwan, A.D.</creator><general>Elsevier Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>19730101</creationdate><title>Experimental warfarin poisoning in the dog: Platelet function, coagulation and fibrinolysis</title><author>Forbes, C.D. ; Thomson, C. ; Prentice, C.R.M. ; McNicol, G.P. ; McEwan, A.D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e285t-7882f84b44b29cc9d37c31e419350ef2e5535308e86763e86ae0f364285ae1b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>animal health</topic><topic>animal injuries</topic><topic>Animals</topic><topic>Blood Coagulation - drug effects</topic><topic>Blood Coagulation Tests</topic><topic>Blood Platelets - drug effects</topic><topic>Dogs</topic><topic>Factor IX</topic><topic>Factor VII</topic><topic>Factor X</topic><topic>Female</topic><topic>Fibrinolysis - drug effects</topic><topic>Hemostasis</topic><topic>Kaolin</topic><topic>Male</topic><topic>Phosphatidylethanolamines</topic><topic>Platelet Adhesiveness</topic><topic>Prothrombin</topic><topic>Prothrombin Time</topic><topic>Serum Globulins</topic><topic>Thrombin</topic><topic>Time Factors</topic><topic>Urea - blood</topic><topic>Vitamin K - therapeutic use</topic><topic>Warfarin - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Forbes, C.D.</creatorcontrib><creatorcontrib>Thomson, C.</creatorcontrib><creatorcontrib>Prentice, C.R.M.</creatorcontrib><creatorcontrib>McNicol, G.P.</creatorcontrib><creatorcontrib>McEwan, A.D.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Journal of comparative pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Forbes, C.D.</au><au>Thomson, C.</au><au>Prentice, C.R.M.</au><au>McNicol, G.P.</au><au>McEwan, A.D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental warfarin poisoning in the dog: Platelet function, coagulation and fibrinolysis</atitle><jtitle>Journal of comparative pathology</jtitle><addtitle>J Comp Pathol</addtitle><date>1973-01-01</date><risdate>1973</risdate><volume>83</volume><issue>2</issue><spage>173</spage><epage>180</epage><pages>173-180</pages><issn>0021-9975</issn><eissn>1532-3129</eissn><abstract>Experimental warfarin poisoning in dogs produced a profound haemostatic defect with depression in the levels of factors II, VII, IX and X and gross prolongation of the bleeding time. Surprisingly platelet function was unaltered suggesting that in the dog the intrinsic coagulation pathway plays an important part in the normal bleeding time. There was slight shortening of the euglobulin lysis time, but no other changes in the components of the fibrinolytic enzyme system. Rapid reversal of the clotting abnormality was produced by the intravenous injection of vitamin K
1.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>4761660</pmid><doi>10.1016/0021-9975(73)90040-6</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of comparative pathology, 1973-01, Vol.83 (2), p.173-180 |
| issn | 0021-9975 1532-3129 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | animal health animal injuries Animals Blood Coagulation - drug effects Blood Coagulation Tests Blood Platelets - drug effects Dogs Factor IX Factor VII Factor X Female Fibrinolysis - drug effects Hemostasis Kaolin Male Phosphatidylethanolamines Platelet Adhesiveness Prothrombin Prothrombin Time Serum Globulins Thrombin Time Factors Urea - blood Vitamin K - therapeutic use Warfarin - toxicity |
| title | Experimental warfarin poisoning in the dog: Platelet function, coagulation and fibrinolysis |
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