In Vitro Studies on Mechanism of the “Eclipse” of Cell-Mediated Immunity in Mice Bearing Advanced Tumors
A characteristic pattern of evolution of cell-mediated antitumor immunity was confirmed in 3 mouse host-tumor systems. This pattern, as defined through the in vitro colony inhibition test after confrontation of target tumor cells with peritoneal cells (PC), included an immunologic “eclipse” period o...
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| Veröffentlicht in: | JNCI : Journal of the National Cancer Institute 1973-04, Vol.50 (4), p.921-926 |
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| container_title | JNCI : Journal of the National Cancer Institute |
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| creator | Youn, Jung Koo Le François, Danielle Barski, Georges |
| description | A characteristic pattern of evolution of cell-mediated antitumor immunity was confirmed in 3 mouse host-tumor systems. This pattern, as defined through the in vitro colony inhibition test after confrontation of target tumor cells with peritoneal cells (PC), included an immunologic “eclipse” period observed regularly in mice bearing tumors ≥ 10 mm in diameter. This eclipse was immunologically specific, not seen in mice with an antigenically unrelated tumor. The mechanism determining the eclipse could be partially explained by experiments in which sera from tumor-bearing mice, incubated with sensitized PC, significantly suppressed their activity. The same sera incubated with the target cells were much less efficient in protecting them against sensitizedPC. The possibility of a central mechanism suppressing the immunologic activity of sensitized PC by circulating tumor antigens or antigen-antibody complexes was discussed. |
| doi_str_mv | 10.1093/jnci/50.4.921 |
| format | Article |
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This pattern, as defined through the in vitro colony inhibition test after confrontation of target tumor cells with peritoneal cells (PC), included an immunologic “eclipse” period observed regularly in mice bearing tumors ≥ 10 mm in diameter. This eclipse was immunologically specific, not seen in mice with an antigenically unrelated tumor. The mechanism determining the eclipse could be partially explained by experiments in which sera from tumor-bearing mice, incubated with sensitized PC, significantly suppressed their activity. The same sera incubated with the target cells were much less efficient in protecting them against sensitizedPC. The possibility of a central mechanism suppressing the immunologic activity of sensitized PC by circulating tumor antigens or antigen-antibody complexes was discussed.</description><identifier>ISSN: 0027-8874</identifier><identifier>EISSN: 1460-2105</identifier><identifier>DOI: 10.1093/jnci/50.4.921</identifier><identifier>PMID: 4735758</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Animals ; Antibody Specificity ; Antigen-Antibody Complex ; Cell Division ; Cell Line ; Clone Cells ; Immunity, Cellular ; Leukemia, Experimental - etiology ; Leukemia, Experimental - immunology ; Mammary Neoplasms, Experimental - immunology ; Methylcholanthrene ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C3H ; Rauscher Virus ; Sarcoma, Experimental - chemically induced ; Sarcoma, Experimental - immunology ; Tumor Virus Infections</subject><ispartof>JNCI : Journal of the National Cancer Institute, 1973-04, Vol.50 (4), p.921-926</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4735758$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Youn, Jung Koo</creatorcontrib><creatorcontrib>Le François, Danielle</creatorcontrib><creatorcontrib>Barski, Georges</creatorcontrib><title>In Vitro Studies on Mechanism of the “Eclipse” of Cell-Mediated Immunity in Mice Bearing Advanced Tumors</title><title>JNCI : Journal of the National Cancer Institute</title><addtitle>Journal of the National Cancer Institute</addtitle><description>A characteristic pattern of evolution of cell-mediated antitumor immunity was confirmed in 3 mouse host-tumor systems. This pattern, as defined through the in vitro colony inhibition test after confrontation of target tumor cells with peritoneal cells (PC), included an immunologic “eclipse” period observed regularly in mice bearing tumors ≥ 10 mm in diameter. This eclipse was immunologically specific, not seen in mice with an antigenically unrelated tumor. The mechanism determining the eclipse could be partially explained by experiments in which sera from tumor-bearing mice, incubated with sensitized PC, significantly suppressed their activity. The same sera incubated with the target cells were much less efficient in protecting them against sensitizedPC. The possibility of a central mechanism suppressing the immunologic activity of sensitized PC by circulating tumor antigens or antigen-antibody complexes was discussed.</description><subject>Animals</subject><subject>Antibody Specificity</subject><subject>Antigen-Antibody Complex</subject><subject>Cell Division</subject><subject>Cell Line</subject><subject>Clone Cells</subject><subject>Immunity, Cellular</subject><subject>Leukemia, Experimental - etiology</subject><subject>Leukemia, Experimental - immunology</subject><subject>Mammary Neoplasms, Experimental - immunology</subject><subject>Methylcholanthrene</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C3H</subject><subject>Rauscher Virus</subject><subject>Sarcoma, Experimental - chemically induced</subject><subject>Sarcoma, Experimental - immunology</subject><subject>Tumor Virus Infections</subject><issn>0027-8874</issn><issn>1460-2105</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j8tOwzAURC0EKqWwZInkH0hrx04cL_uCVmrFgoIQm8ixr6lLHlUeiO76IfBz_RKCWjGbkebMvdIgdEtJnxLJBptcu0FA-rwvfXqGupSHxPMpCc5RlxBfeFEk-CW6qqoNaSV93kEdLlgggqiL0nmOX1xdFvipboyDChc5XoJeq9xVGS4srteAD_vvqU7dtoLD_ucvHEOaekswTtVg8DzLmtzVO-zaW6cBj0CVLn_HQ_Opct02Vk1WlNU1urAqreDm5D30fD9djWfe4vFhPh4uPEdFWHvUMm1BGqlNpDRlEWhLQws0CayNIs64jYRJNE0MkWB8AUkgtWY8CQWnSrIeujv-3TZJBibeli5T5S4-rW65d-SuquHrH6vyIw4FE0E8e32LRTiahGQ2iX32C9NYa3Y</recordid><startdate>197304</startdate><enddate>197304</enddate><creator>Youn, Jung Koo</creator><creator>Le François, Danielle</creator><creator>Barski, Georges</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>197304</creationdate><title>In Vitro Studies on Mechanism of the “Eclipse” of Cell-Mediated Immunity in Mice Bearing Advanced Tumors</title><author>Youn, Jung Koo ; Le François, Danielle ; Barski, Georges</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i176t-1f3cfe9d9cd8ac138ecf16fe1b5ff88434f87dbc1bd09ed27eb59cc34b6741a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Animals</topic><topic>Antibody Specificity</topic><topic>Antigen-Antibody Complex</topic><topic>Cell Division</topic><topic>Cell Line</topic><topic>Clone Cells</topic><topic>Immunity, Cellular</topic><topic>Leukemia, Experimental - etiology</topic><topic>Leukemia, Experimental - immunology</topic><topic>Mammary Neoplasms, Experimental - immunology</topic><topic>Methylcholanthrene</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C3H</topic><topic>Rauscher Virus</topic><topic>Sarcoma, Experimental - chemically induced</topic><topic>Sarcoma, Experimental - immunology</topic><topic>Tumor Virus Infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Youn, Jung Koo</creatorcontrib><creatorcontrib>Le François, Danielle</creatorcontrib><creatorcontrib>Barski, Georges</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>JNCI : Journal of the National Cancer Institute</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Youn, Jung Koo</au><au>Le François, Danielle</au><au>Barski, Georges</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In Vitro Studies on Mechanism of the “Eclipse” of Cell-Mediated Immunity in Mice Bearing Advanced Tumors</atitle><jtitle>JNCI : Journal of the National Cancer Institute</jtitle><addtitle>Journal of the National Cancer Institute</addtitle><date>1973-04</date><risdate>1973</risdate><volume>50</volume><issue>4</issue><spage>921</spage><epage>926</epage><pages>921-926</pages><issn>0027-8874</issn><eissn>1460-2105</eissn><abstract>A characteristic pattern of evolution of cell-mediated antitumor immunity was confirmed in 3 mouse host-tumor systems. 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| ispartof | JNCI : Journal of the National Cancer Institute, 1973-04, Vol.50 (4), p.921-926 |
| issn | 0027-8874 1460-2105 |
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| source | Oxford University Press Journals Digital Archive legacy; MEDLINE |
| subjects | Animals Antibody Specificity Antigen-Antibody Complex Cell Division Cell Line Clone Cells Immunity, Cellular Leukemia, Experimental - etiology Leukemia, Experimental - immunology Mammary Neoplasms, Experimental - immunology Methylcholanthrene Mice Mice, Inbred BALB C Mice, Inbred C3H Rauscher Virus Sarcoma, Experimental - chemically induced Sarcoma, Experimental - immunology Tumor Virus Infections |
| title | In Vitro Studies on Mechanism of the “Eclipse” of Cell-Mediated Immunity in Mice Bearing Advanced Tumors |
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