Active Chronic Hepatitis: Use of Bromosulphthalein Tm and S in Estimating Disease Activity
The value of estimating the hepatic transport maximum (Tm) and storage (S) of bromosulphthalein in assessment of disease activity in 14 cases of active chronic hepatitis was investigated. Patients with active disease had a lower S and Tm than normal controls or patients with inactive disease. Patien...
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| Veröffentlicht in: | Scandinavian journal of gastroenterology 1972, Vol.7 (8), p.737-741 |
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| container_title | Scandinavian journal of gastroenterology |
| container_volume | 7 |
| creator | Goldstein, G. Mistilis, S. P. |
| description | The value of estimating the hepatic transport maximum (Tm) and storage (S) of bromosulphthalein in assessment of disease activity in 14 cases of active chronic hepatitis was investigated. Patients with active disease had a lower S and Tm than normal controls or patients with inactive disease. Patients with inactive disease had a normal Tm but a low S. Analysis of variance of liver function tests showed that Tm was the best single index of disease activity. Patients previously considered to have inactive liver disease may in fact have low grade activity which can only be demonstrated by measurement of the Tm. |
| doi_str_mv | 10.3109/00365527209180989 |
| format | Article |
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Patients previously considered to have inactive liver disease may in fact have low grade activity which can only be demonstrated by measurement of the Tm.</description><identifier>ISSN: 0036-5521</identifier><identifier>EISSN: 1502-7708</identifier><identifier>DOI: 10.3109/00365527209180989</identifier><identifier>PMID: 4640653</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Adolescent ; Adult ; Azathioprine - therapeutic use ; Biological Transport ; Child ; Female ; Hepatitis ; Hepatitis - diagnosis ; Hepatitis - drug therapy ; Humans ; Liver - metabolism ; Liver Function Tests ; Male ; Middle Aged ; Prednisone - therapeutic use ; sulfobromophthalein ; Sulfobromophthalein - metabolism</subject><ispartof>Scandinavian journal of gastroenterology, 1972, Vol.7 (8), p.737-741</ispartof><rights>1972 Informa UK Ltd 1972</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-57b220d99e4b200a30b6b0009063c0c505644979591f9ea258bb11db4ee3f6373</citedby><cites>FETCH-LOGICAL-c316t-57b220d99e4b200a30b6b0009063c0c505644979591f9ea258bb11db4ee3f6373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/00365527209180989$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/00365527209180989$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,776,780,4010,27900,27901,27902,59620,59726,60409,60515,61194,61229,61375,61410</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4640653$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goldstein, G.</creatorcontrib><creatorcontrib>Mistilis, S. P.</creatorcontrib><title>Active Chronic Hepatitis: Use of Bromosulphthalein Tm and S in Estimating Disease Activity</title><title>Scandinavian journal of gastroenterology</title><addtitle>Scand J Gastroenterol</addtitle><description>The value of estimating the hepatic transport maximum (Tm) and storage (S) of bromosulphthalein in assessment of disease activity in 14 cases of active chronic hepatitis was investigated. Patients with active disease had a lower S and Tm than normal controls or patients with inactive disease. Patients with inactive disease had a normal Tm but a low S. Analysis of variance of liver function tests showed that Tm was the best single index of disease activity. Patients previously considered to have inactive liver disease may in fact have low grade activity which can only be demonstrated by measurement of the Tm.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Azathioprine - therapeutic use</subject><subject>Biological Transport</subject><subject>Child</subject><subject>Female</subject><subject>Hepatitis</subject><subject>Hepatitis - diagnosis</subject><subject>Hepatitis - drug therapy</subject><subject>Humans</subject><subject>Liver - metabolism</subject><subject>Liver Function Tests</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prednisone - therapeutic use</subject><subject>sulfobromophthalein</subject><subject>Sulfobromophthalein - metabolism</subject><issn>0036-5521</issn><issn>1502-7708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1972</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFP3DAUhC3Uim6BH9ADkk-9hT7HsROXXpaFFiQkDsCll8hxXhqjJF5sp2j_fb3dFVJVtaf3pJlvNBpCPjA44wzUJwAuhcjLHBSrQFXqgCyYgDwrS6jekMVWz5KBvSPvQ3gCAFEW6pAcFrIAKfiCfF-aaH8iXfXeTdbQa1zraKMNn-ljQOo6euHd6MI8rPvY6wHtRB9GqqeW3tP0X4Vox0RMP-ilDagT8zvRxs0xedvpIeDJ_h6Rx69XD6vr7Pbu281qeZsZzmTMRNnkObRKYdHkAJpDI5vUVIHkBowAIYtClUoo1inUuaiahrG2KRB5J3nJj8jHXe7au-cZQ6xHGwwOg57QzaGumJQq5yIZ2c5ovAvBY1evfSrvNzWDertn_deeiTndh8_NiO0rsR8w6V92up0650f94vzQ1lFvBuc7rydjwzb63_Hnf-A96iH2Rnusn9zsp7Tbf8r9AnkElBU</recordid><startdate>1972</startdate><enddate>1972</enddate><creator>Goldstein, G.</creator><creator>Mistilis, S. P.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1972</creationdate><title>Active Chronic Hepatitis: Use of Bromosulphthalein Tm and S in Estimating Disease Activity</title><author>Goldstein, G. ; Mistilis, S. P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-57b220d99e4b200a30b6b0009063c0c505644979591f9ea258bb11db4ee3f6373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1972</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Azathioprine - therapeutic use</topic><topic>Biological Transport</topic><topic>Child</topic><topic>Female</topic><topic>Hepatitis</topic><topic>Hepatitis - diagnosis</topic><topic>Hepatitis - drug therapy</topic><topic>Humans</topic><topic>Liver - metabolism</topic><topic>Liver Function Tests</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prednisone - therapeutic use</topic><topic>sulfobromophthalein</topic><topic>Sulfobromophthalein - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goldstein, G.</creatorcontrib><creatorcontrib>Mistilis, S. 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P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Active Chronic Hepatitis: Use of Bromosulphthalein Tm and S in Estimating Disease Activity</atitle><jtitle>Scandinavian journal of gastroenterology</jtitle><addtitle>Scand J Gastroenterol</addtitle><date>1972</date><risdate>1972</risdate><volume>7</volume><issue>8</issue><spage>737</spage><epage>741</epage><pages>737-741</pages><issn>0036-5521</issn><eissn>1502-7708</eissn><abstract>The value of estimating the hepatic transport maximum (Tm) and storage (S) of bromosulphthalein in assessment of disease activity in 14 cases of active chronic hepatitis was investigated. Patients with active disease had a lower S and Tm than normal controls or patients with inactive disease. Patients with inactive disease had a normal Tm but a low S. Analysis of variance of liver function tests showed that Tm was the best single index of disease activity. Patients previously considered to have inactive liver disease may in fact have low grade activity which can only be demonstrated by measurement of the Tm.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>4640653</pmid><doi>10.3109/00365527209180989</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-5521 |
| ispartof | Scandinavian journal of gastroenterology, 1972, Vol.7 (8), p.737-741 |
| issn | 0036-5521 1502-7708 |
| language | eng |
| recordid | cdi_pubmed_primary_4640653 |
| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Adolescent Adult Azathioprine - therapeutic use Biological Transport Child Female Hepatitis Hepatitis - diagnosis Hepatitis - drug therapy Humans Liver - metabolism Liver Function Tests Male Middle Aged Prednisone - therapeutic use sulfobromophthalein Sulfobromophthalein - metabolism |
| title | Active Chronic Hepatitis: Use of Bromosulphthalein Tm and S in Estimating Disease Activity |
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