Toxicity of metabolic benzo(a)pyrenediones to cultured cells and the dependence upon molecular oxygen

The three quinone metabolites of carcinogenic benzo(a)pyrene, the isomeric benzo(a)pyrenediones (6, 12; 1,6; 3,6), are toxic to cultured hamster cells at low concentrations. The reduction in cell number, observed after treatment with these metabolites, is the result of both direct cell killing and t...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1979-08, Vol.39 (8), p.3194
Hauptverfasser:	Lorentzen, R J, Lesko, S A, McDonald, K, Ts'o, P O
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzopyrenes - toxicity Cell Division - drug effects Cell Survival - drug effects Cells, Cultured Cricetinae DNA - biosynthesis Embryo, Mammalian Oxidation-Reduction Oxygen RNA - biosynthesis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!