Methadone Plasma Level: Sustained by a Reservoir of Drug in Tissue
Binding of methadone in body tissues limits the rise in plasma concentration and prolongs the pharmacological action in patients receiving a daily maintenance dose. An opiate with equal intrinsic activity but greater binding affinity would, therefore, be a better drug than methadone for maintenance...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1973-01, Vol.70 (1), p.10-10 |
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| Sprache: | eng |
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| container_issue | 1 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 70 |
| creator | Dole, Vincent P. Kreek, Mary Jeanne |
| description | Binding of methadone in body tissues limits the rise in plasma concentration and prolongs the pharmacological action in patients receiving a daily maintenance dose. An opiate with equal intrinsic activity but greater binding affinity would, therefore, be a better drug than methadone for maintenance treatment; it would be safer when taken in a single dose and longer in its duration of action when taken on a regular schedule. |
| doi_str_mv | 10.1073/pnas.70.1.10 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1973-01, Vol.70 (1), p.10-10 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_pubmed_primary_4509643 |
| source | Jstor Complete Legacy; MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Biological Sciences: Medical Sciences Blood plasma Dosage Heroin Dependence - drug therapy Humans Ingestion Methadone Methadone - administration & dosage Methadone - blood Methadone - metabolism Methadone - therapeutic use Methadone - urine Narcotics Pharmacology Time Factors Urine |
| title | Methadone Plasma Level: Sustained by a Reservoir of Drug in Tissue |
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