Adrenocortical Function in Fever
Abstract Signs of increased or normal adrenocortical function are found in patients suffering from severe bacterial infections. To further study the adrenocortical function in fever, 8 guinea pigs were injected daily with TAB vaccine for 9 days. 42 patients suffering from purulent meningitis and pne...
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| Veröffentlicht in: | Scandinavian journal of infectious diseases 1969-08, Vol.1 (2), p.107-111 |
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| container_title | Scandinavian journal of infectious diseases |
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| creator | Bassoe, H H |
| description | Abstract
Signs of increased or normal adrenocortical function are found in patients suffering from severe bacterial infections. To further study the adrenocortical function in fever, 8 guinea pigs were injected daily with TAB vaccine for 9 days. 42 patients suffering from purulent meningitis and pneumonia were also investigated. The adrenocortical function was estimated by the urinary output of 17-KS and 17-OHCS in the guinea pigs, and similar methods were applied in 19 patients. In addition estimation of plasma 17-OHCS was carried out in 23 patients. An increased adrenocortical function was demonstrated in guinea pigs as well as in humans during the first days of a febrile response. Later on the adrenocortical function was found to be within normal limits whether the temperature was normal or not. "The normal functioning adrenal cortex" in severe infectious diseases is rather a sign of adaptation to the stressor, and no evidence was found pointing to a development of adrenocortical failure or exhaustion. |
| doi_str_mv | 10.3109/inf.1969.1.issue-2.06 |
| format | Article |
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Signs of increased or normal adrenocortical function are found in patients suffering from severe bacterial infections. To further study the adrenocortical function in fever, 8 guinea pigs were injected daily with TAB vaccine for 9 days. 42 patients suffering from purulent meningitis and pneumonia were also investigated. The adrenocortical function was estimated by the urinary output of 17-KS and 17-OHCS in the guinea pigs, and similar methods were applied in 19 patients. In addition estimation of plasma 17-OHCS was carried out in 23 patients. An increased adrenocortical function was demonstrated in guinea pigs as well as in humans during the first days of a febrile response. Later on the adrenocortical function was found to be within normal limits whether the temperature was normal or not. "The normal functioning adrenal cortex" in severe infectious diseases is rather a sign of adaptation to the stressor, and no evidence was found pointing to a development of adrenocortical failure or exhaustion.</description><identifier>ISSN: 0036-5548</identifier><identifier>EISSN: 1651-1980</identifier><identifier>DOI: 10.3109/inf.1969.1.issue-2.06</identifier><identifier>PMID: 4329059</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>17-Hydroxycorticosteroids - blood ; 17-Hydroxycorticosteroids - urine ; 17-Ketosteroids - blood ; 17-Ketosteroids - urine ; Adolescent ; Adrenal Glands - metabolism ; Adrenal Glands - physiopathology ; Adrenocorticotropic Hormone - metabolism ; Adult ; Aged ; Animals ; Bacterial Infections - blood ; Bacterial Infections - physiopathology ; Bacterial Infections - urine ; Female ; Fever - physiopathology ; Guinea Pigs ; Humans ; Male ; Meningitis - blood ; Meningitis - urine ; Middle Aged ; Time Factors</subject><ispartof>Scandinavian journal of infectious diseases, 1969-08, Vol.1 (2), p.107-111</ispartof><rights>1969 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1969</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-813e4258493739e2554b180304eee5579cee4685399426d2355a69e1789d5d623</citedby><cites>FETCH-LOGICAL-c332t-813e4258493739e2554b180304eee5579cee4685399426d2355a69e1789d5d623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/inf.1969.1.issue-2.06$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/inf.1969.1.issue-2.06$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,59646,60435,61220,61401</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4329059$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bassoe, H H</creatorcontrib><title>Adrenocortical Function in Fever</title><title>Scandinavian journal of infectious diseases</title><addtitle>Scand J Infect Dis</addtitle><description>Abstract
Signs of increased or normal adrenocortical function are found in patients suffering from severe bacterial infections. To further study the adrenocortical function in fever, 8 guinea pigs were injected daily with TAB vaccine for 9 days. 42 patients suffering from purulent meningitis and pneumonia were also investigated. The adrenocortical function was estimated by the urinary output of 17-KS and 17-OHCS in the guinea pigs, and similar methods were applied in 19 patients. In addition estimation of plasma 17-OHCS was carried out in 23 patients. An increased adrenocortical function was demonstrated in guinea pigs as well as in humans during the first days of a febrile response. Later on the adrenocortical function was found to be within normal limits whether the temperature was normal or not. "The normal functioning adrenal cortex" in severe infectious diseases is rather a sign of adaptation to the stressor, and no evidence was found pointing to a development of adrenocortical failure or exhaustion.</description><subject>17-Hydroxycorticosteroids - blood</subject><subject>17-Hydroxycorticosteroids - urine</subject><subject>17-Ketosteroids - blood</subject><subject>17-Ketosteroids - urine</subject><subject>Adolescent</subject><subject>Adrenal Glands - metabolism</subject><subject>Adrenal Glands - physiopathology</subject><subject>Adrenocorticotropic Hormone - metabolism</subject><subject>Adult</subject><subject>Aged</subject><subject>Animals</subject><subject>Bacterial Infections - blood</subject><subject>Bacterial Infections - physiopathology</subject><subject>Bacterial Infections - urine</subject><subject>Female</subject><subject>Fever - physiopathology</subject><subject>Guinea Pigs</subject><subject>Humans</subject><subject>Male</subject><subject>Meningitis - blood</subject><subject>Meningitis - urine</subject><subject>Middle Aged</subject><subject>Time Factors</subject><issn>0036-5548</issn><issn>1651-1980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1969</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1PwzAQhi0EKqXwEyplYkvwd-0JqooCUiUWmC3XuaipErvYCYh_T0orJBaYbrh7n_f0IDQluGAE65vaVwXRUhekqFPqIacFlidoTKQgOdEKn6IxxkzmQnB1ji5S2mKMuWR4hEacUY2FHqNsXkbwwYXY1c422bL3rquDz2qfLeEd4iU6q2yT4Oo4J-h1ef-yeMxXzw9Pi_kqd4zRLleEAadCcc1mTAMdStdEYYY5AAgx0w6ASyWY1pzKkjIhrNRAZkqXopSUTdD1gbuL4a2H1Jm2Tg6axnoIfTKKC6L5gJ8gcTh0MaQUoTK7WLc2fhqCzd6MGcyYvRlDzLcZQw2WQ256LOjXLZQ_qaOKYX932A_xEFv7EWJTms5-NiFW0XpXpz3-74rbX4gN2KbbOBvBbEMf_eDvnye_AJpRizk</recordid><startdate>19690801</startdate><enddate>19690801</enddate><creator>Bassoe, H H</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19690801</creationdate><title>Adrenocortical Function in Fever</title><author>Bassoe, H H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-813e4258493739e2554b180304eee5579cee4685399426d2355a69e1789d5d623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1969</creationdate><topic>17-Hydroxycorticosteroids - blood</topic><topic>17-Hydroxycorticosteroids - urine</topic><topic>17-Ketosteroids - blood</topic><topic>17-Ketosteroids - urine</topic><topic>Adolescent</topic><topic>Adrenal Glands - metabolism</topic><topic>Adrenal Glands - physiopathology</topic><topic>Adrenocorticotropic Hormone - metabolism</topic><topic>Adult</topic><topic>Aged</topic><topic>Animals</topic><topic>Bacterial Infections - blood</topic><topic>Bacterial Infections - physiopathology</topic><topic>Bacterial Infections - urine</topic><topic>Female</topic><topic>Fever - physiopathology</topic><topic>Guinea Pigs</topic><topic>Humans</topic><topic>Male</topic><topic>Meningitis - blood</topic><topic>Meningitis - urine</topic><topic>Middle Aged</topic><topic>Time Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>Bassoe, H H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bassoe, H H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adrenocortical Function in Fever</atitle><jtitle>Scandinavian journal of infectious diseases</jtitle><addtitle>Scand J Infect Dis</addtitle><date>1969-08-01</date><risdate>1969</risdate><volume>1</volume><issue>2</issue><spage>107</spage><epage>111</epage><pages>107-111</pages><issn>0036-5548</issn><eissn>1651-1980</eissn><abstract>Abstract
Signs of increased or normal adrenocortical function are found in patients suffering from severe bacterial infections. To further study the adrenocortical function in fever, 8 guinea pigs were injected daily with TAB vaccine for 9 days. 42 patients suffering from purulent meningitis and pneumonia were also investigated. The adrenocortical function was estimated by the urinary output of 17-KS and 17-OHCS in the guinea pigs, and similar methods were applied in 19 patients. In addition estimation of plasma 17-OHCS was carried out in 23 patients. An increased adrenocortical function was demonstrated in guinea pigs as well as in humans during the first days of a febrile response. Later on the adrenocortical function was found to be within normal limits whether the temperature was normal or not. "The normal functioning adrenal cortex" in severe infectious diseases is rather a sign of adaptation to the stressor, and no evidence was found pointing to a development of adrenocortical failure or exhaustion.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>4329059</pmid><doi>10.3109/inf.1969.1.issue-2.06</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-5548 |
| ispartof | Scandinavian journal of infectious diseases, 1969-08, Vol.1 (2), p.107-111 |
| issn | 0036-5548 1651-1980 |
| language | eng |
| recordid | cdi_pubmed_primary_4329059 |
| source | MEDLINE; Taylor & Francis Journals Complete |
| subjects | 17-Hydroxycorticosteroids - blood 17-Hydroxycorticosteroids - urine 17-Ketosteroids - blood 17-Ketosteroids - urine Adolescent Adrenal Glands - metabolism Adrenal Glands - physiopathology Adrenocorticotropic Hormone - metabolism Adult Aged Animals Bacterial Infections - blood Bacterial Infections - physiopathology Bacterial Infections - urine Female Fever - physiopathology Guinea Pigs Humans Male Meningitis - blood Meningitis - urine Middle Aged Time Factors |
| title | Adrenocortical Function in Fever |
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