Laboratory induction and clinical occurrence of combined clindamycin and erythromycin resistance in Corynebacterium acnes

Corynebacterium acnes strains cross-resistant to clindamycin and erythromycin were observed following long-term selection or mutagenic treatment in the laboratory. Similar strains were found among clinical isolates from patients using clindamycin or erythromycin topically in the treatment of acne vu...

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Veröffentlicht in:Journal of investigative dermatology 1979-04, Vol.72 (4), p.187
Hauptverfasser: Crawford, W W, Crawford, I P, Stoughton, R B, Cornell, R C
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container_title Journal of investigative dermatology
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creator Crawford, W W
Crawford, I P
Stoughton, R B
Cornell, R C
description Corynebacterium acnes strains cross-resistant to clindamycin and erythromycin were observed following long-term selection or mutagenic treatment in the laboratory. Similar strains were found among clinical isolates from patients using clindamycin or erythromycin topically in the treatment of acne vulgaris. Clindamycin resistance was never observed in the absence of resistance to macrolides or other lincosaminides. It is suggested that this resistance may result from an alteration of the 50S ribosomal subunit.
doi_str_mv 10.1111/1523-1747.ep12676385
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source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection
subjects Clindamycin - pharmacology
Drug Resistance, Microbial
Erythromycin - pharmacology
Propionibacterium acnes - drug effects
title Laboratory induction and clinical occurrence of combined clindamycin and erythromycin resistance in Corynebacterium acnes
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