Cell-mediated lympholysis. Importance of serologically defined H-2 regions
The cell-mediated lympholytic capability of mouse spleen cells stimulated in mixed lymphocyte culture is related to the major histocompatibility complex genotype on target lymphocytes. The strain combinations AQR-B10. T(6R) and B10.A(4R)-B10.A(2R) that result in significant mixed lymphocyte culture...
Gespeichert in:
| Veröffentlicht in: | The Journal of experimental medicine 1973-05, Vol.137 (5), p.1303 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 5 |
| container_start_page | 1303 |
| container_title | The Journal of experimental medicine |
| container_volume | 137 |
| creator | Alter, B J Schendel, D J Bach, M L Bach, F H Klein, J Stimpfling, J H |
| description | The cell-mediated lympholytic capability of mouse spleen cells stimulated in mixed lymphocyte culture is related to the major histocompatibility complex genotype on target lymphocytes. The strain combinations AQR-B10. T(6R) and B10.A(4R)-B10.A(2R) that result in significant mixed lymphocyte culture activation do not mediate cell-mediated lympholysis on sensitizing target lymphocytes; serologically defined regions (H-2K and H-2D) are identical within each combination. H-2K or H-2D region disparity alone does not cause cell-mediated lympholysis. However after mixed lymphocyte culture activation as seen with B10.A-B10.T(6R), a target cell bearing only an H-2K region difference from the effector cell is sensitive to cell-mediated lympholysis. Likewise an H-2D region difference is an adequate target after mixed lymphocyte culture activation of the effector cell in the combination B10.A(2R)-B10.D2. |
| doi_str_mv | 10.1084/jem.137.5.1303 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed</sourceid><recordid>TN_cdi_pubmed_primary_4267208</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4267208</sourcerecordid><originalsourceid>FETCH-LOGICAL-p206t-cda8d42979ca297ef36aee7376ed5f848c2a2f29161497319c037abe6e7e91163</originalsourceid><addsrcrecordid>eNotj71OwzAYRT2ASimsbEh-Aaf-ix2PKAJaVIkF5sq1PxdXThzFYcjbE4ku50736F6EnhitGG3k9gJdxYSu6oVU3KA1pZwTRqm-Q_elXChlUtZqhVaSK81ps0YfLaREOvDRTuBxmrvhJ6e5xFLhfTfkcbK9A5wDLjDmlM_R2ZRm7CHEfinsCMcjnGPuywO6DTYVeLzmBn2_vX61O3L4fN-3LwcycKom4rxtvORGG2cXQhDKAmihFfg6NLJx3PLADVNMGi2YcVRoewIFGgxjSmzQ8793-D0tw4_DGDs7zsfrJ_EHNI5MMw</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Cell-mediated lympholysis. Importance of serologically defined H-2 regions</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Alter, B J ; Schendel, D J ; Bach, M L ; Bach, F H ; Klein, J ; Stimpfling, J H</creator><creatorcontrib>Alter, B J ; Schendel, D J ; Bach, M L ; Bach, F H ; Klein, J ; Stimpfling, J H</creatorcontrib><description>The cell-mediated lympholytic capability of mouse spleen cells stimulated in mixed lymphocyte culture is related to the major histocompatibility complex genotype on target lymphocytes. The strain combinations AQR-B10. T(6R) and B10.A(4R)-B10.A(2R) that result in significant mixed lymphocyte culture activation do not mediate cell-mediated lympholysis on sensitizing target lymphocytes; serologically defined regions (H-2K and H-2D) are identical within each combination. H-2K or H-2D region disparity alone does not cause cell-mediated lympholysis. However after mixed lymphocyte culture activation as seen with B10.A-B10.T(6R), a target cell bearing only an H-2K region difference from the effector cell is sensitive to cell-mediated lympholysis. Likewise an H-2D region difference is an adequate target after mixed lymphocyte culture activation of the effector cell in the combination B10.A(2R)-B10.D2.</description><identifier>ISSN: 0022-1007</identifier><identifier>DOI: 10.1084/jem.137.5.1303</identifier><identifier>PMID: 4267208</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Antigen-Antibody Reactions ; Chromium Isotopes ; Chromosomes ; Cytotoxicity Tests, Immunologic ; Histocompatibility ; Immunity, Cellular ; Lymphocyte Activation ; Lymphocyte Culture Test, Mixed ; Lymphocytes - immunology ; Mice ; Recombination, Genetic ; Spleen - immunology</subject><ispartof>The Journal of experimental medicine, 1973-05, Vol.137 (5), p.1303</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4267208$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alter, B J</creatorcontrib><creatorcontrib>Schendel, D J</creatorcontrib><creatorcontrib>Bach, M L</creatorcontrib><creatorcontrib>Bach, F H</creatorcontrib><creatorcontrib>Klein, J</creatorcontrib><creatorcontrib>Stimpfling, J H</creatorcontrib><title>Cell-mediated lympholysis. Importance of serologically defined H-2 regions</title><title>The Journal of experimental medicine</title><addtitle>J Exp Med</addtitle><description>The cell-mediated lympholytic capability of mouse spleen cells stimulated in mixed lymphocyte culture is related to the major histocompatibility complex genotype on target lymphocytes. The strain combinations AQR-B10. T(6R) and B10.A(4R)-B10.A(2R) that result in significant mixed lymphocyte culture activation do not mediate cell-mediated lympholysis on sensitizing target lymphocytes; serologically defined regions (H-2K and H-2D) are identical within each combination. H-2K or H-2D region disparity alone does not cause cell-mediated lympholysis. However after mixed lymphocyte culture activation as seen with B10.A-B10.T(6R), a target cell bearing only an H-2K region difference from the effector cell is sensitive to cell-mediated lympholysis. Likewise an H-2D region difference is an adequate target after mixed lymphocyte culture activation of the effector cell in the combination B10.A(2R)-B10.D2.</description><subject>Animals</subject><subject>Antigen-Antibody Reactions</subject><subject>Chromium Isotopes</subject><subject>Chromosomes</subject><subject>Cytotoxicity Tests, Immunologic</subject><subject>Histocompatibility</subject><subject>Immunity, Cellular</subject><subject>Lymphocyte Activation</subject><subject>Lymphocyte Culture Test, Mixed</subject><subject>Lymphocytes - immunology</subject><subject>Mice</subject><subject>Recombination, Genetic</subject><subject>Spleen - immunology</subject><issn>0022-1007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotj71OwzAYRT2ASimsbEh-Aaf-ix2PKAJaVIkF5sq1PxdXThzFYcjbE4ku50736F6EnhitGG3k9gJdxYSu6oVU3KA1pZwTRqm-Q_elXChlUtZqhVaSK81ps0YfLaREOvDRTuBxmrvhJ6e5xFLhfTfkcbK9A5wDLjDmlM_R2ZRm7CHEfinsCMcjnGPuywO6DTYVeLzmBn2_vX61O3L4fN-3LwcycKom4rxtvORGG2cXQhDKAmihFfg6NLJx3PLADVNMGi2YcVRoewIFGgxjSmzQ8793-D0tw4_DGDs7zsfrJ_EHNI5MMw</recordid><startdate>19730501</startdate><enddate>19730501</enddate><creator>Alter, B J</creator><creator>Schendel, D J</creator><creator>Bach, M L</creator><creator>Bach, F H</creator><creator>Klein, J</creator><creator>Stimpfling, J H</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>19730501</creationdate><title>Cell-mediated lympholysis. Importance of serologically defined H-2 regions</title><author>Alter, B J ; Schendel, D J ; Bach, M L ; Bach, F H ; Klein, J ; Stimpfling, J H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p206t-cda8d42979ca297ef36aee7376ed5f848c2a2f29161497319c037abe6e7e91163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Animals</topic><topic>Antigen-Antibody Reactions</topic><topic>Chromium Isotopes</topic><topic>Chromosomes</topic><topic>Cytotoxicity Tests, Immunologic</topic><topic>Histocompatibility</topic><topic>Immunity, Cellular</topic><topic>Lymphocyte Activation</topic><topic>Lymphocyte Culture Test, Mixed</topic><topic>Lymphocytes - immunology</topic><topic>Mice</topic><topic>Recombination, Genetic</topic><topic>Spleen - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alter, B J</creatorcontrib><creatorcontrib>Schendel, D J</creatorcontrib><creatorcontrib>Bach, M L</creatorcontrib><creatorcontrib>Bach, F H</creatorcontrib><creatorcontrib>Klein, J</creatorcontrib><creatorcontrib>Stimpfling, J H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>The Journal of experimental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alter, B J</au><au>Schendel, D J</au><au>Bach, M L</au><au>Bach, F H</au><au>Klein, J</au><au>Stimpfling, J H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cell-mediated lympholysis. Importance of serologically defined H-2 regions</atitle><jtitle>The Journal of experimental medicine</jtitle><addtitle>J Exp Med</addtitle><date>1973-05-01</date><risdate>1973</risdate><volume>137</volume><issue>5</issue><spage>1303</spage><pages>1303-</pages><issn>0022-1007</issn><abstract>The cell-mediated lympholytic capability of mouse spleen cells stimulated in mixed lymphocyte culture is related to the major histocompatibility complex genotype on target lymphocytes. The strain combinations AQR-B10. T(6R) and B10.A(4R)-B10.A(2R) that result in significant mixed lymphocyte culture activation do not mediate cell-mediated lympholysis on sensitizing target lymphocytes; serologically defined regions (H-2K and H-2D) are identical within each combination. H-2K or H-2D region disparity alone does not cause cell-mediated lympholysis. However after mixed lymphocyte culture activation as seen with B10.A-B10.T(6R), a target cell bearing only an H-2K region difference from the effector cell is sensitive to cell-mediated lympholysis. Likewise an H-2D region difference is an adequate target after mixed lymphocyte culture activation of the effector cell in the combination B10.A(2R)-B10.D2.</abstract><cop>United States</cop><pmid>4267208</pmid><doi>10.1084/jem.137.5.1303</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1007 |
| ispartof | The Journal of experimental medicine, 1973-05, Vol.137 (5), p.1303 |
| issn | 0022-1007 |
| language | eng |
| recordid | cdi_pubmed_primary_4267208 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Antigen-Antibody Reactions Chromium Isotopes Chromosomes Cytotoxicity Tests, Immunologic Histocompatibility Immunity, Cellular Lymphocyte Activation Lymphocyte Culture Test, Mixed Lymphocytes - immunology Mice Recombination, Genetic Spleen - immunology |
| title | Cell-mediated lympholysis. Importance of serologically defined H-2 regions |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T14%3A24%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cell-mediated%20lympholysis.%20Importance%20of%20serologically%20defined%20H-2%20regions&rft.jtitle=The%20Journal%20of%20experimental%20medicine&rft.au=Alter,%20B%20J&rft.date=1973-05-01&rft.volume=137&rft.issue=5&rft.spage=1303&rft.pages=1303-&rft.issn=0022-1007&rft_id=info:doi/10.1084/jem.137.5.1303&rft_dat=%3Cpubmed%3E4267208%3C/pubmed%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/4267208&rfr_iscdi=true |