Polychlorinated Biphenyls: A New Type of Inducer of Cytochrome P-448 in the Liver

The CO-difference spectrum of microsomes from rats treated with the polychlorinated biphenyls mixture, Aroclor 1254, has an absorption maximum at 448 nm. With ethylisocyananide as the ligand for reduced microsomes, Aroclor 1254 treatment causes a shift in the 455-nm peak to 453 nm and increases the...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1973-05, Vol.70 (5), p.1321-1325
Hauptverfasser:	Alvares, Alvito P., Bickers, David R., Kappas, Attallah
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinomycin Animals Benzopyrenes Biological Sciences: Medical Sciences Carbon Monoxide Cytochrome P-450 Enzyme System - analysis Cytochromes Cytochromes - analysis Cytochromes - biosynthesis Dactinomycin - pharmacology Dosage Enzyme Induction Enzymes Human resources Ligands Liver Male Metabolism Methylcholanthrene - pharmacology Microsomes Microsomes, Liver - enzymology Mixed Function Oxygenases - analysis Morphinans Nitriles Oxidoreductases, N-Demethylating - analysis Phenobarbital - pharmacology Polychlorinated biphenyls Polychlorinated Biphenyls - pharmacology Polycyclic compounds Rats Spectrophotometry Stimulation, Chemical
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