Effect of the Skeletal Muscle Relaxant Dantrolene Sodium on the Isolated, Perfused Heart
Summary The literature indicates that dantrolene sodium has produced negligible cardiovascular changes in intact dogs and in patients, but caused depression in the isolated perfused heart. In nine consecutive experiments rat hearts were perfused by means of a modified Langendorff preparation with 3....
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1979-01, Vol.160 (1), p.42-45 |
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| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 160 |
| creator | Gollan, Frank McDermott, Joanne |
| description | Summary
The literature indicates that dantrolene sodium has produced negligible cardiovascular changes in intact dogs and in patients, but caused depression in the isolated perfused heart. In nine consecutive experiments rat hearts were perfused by means of a modified Langendorff preparation with 3.5% bovine albumin in buffered, mammalian Ringer's solution. Perfusion pressure and temperature were kept constant. Flow was measured with an infrared drop counter. Continuous recordings were made of heart rate, coronary flow, resting length, intraventricular pressure, force displacement and their first derivatives. Statistical analysis of all parameters before and during the perfusion with dantrolene sodium solution showed no significant changes for the same period of time. These results show that dantrolene sodium has no effect and do not confirm recent publications which reported a marked myocardial depression by dantrolene sodium. |
| doi_str_mv | 10.3181/00379727-160-40384 |
| format | Article |
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The literature indicates that dantrolene sodium has produced negligible cardiovascular changes in intact dogs and in patients, but caused depression in the isolated perfused heart. In nine consecutive experiments rat hearts were perfused by means of a modified Langendorff preparation with 3.5% bovine albumin in buffered, mammalian Ringer's solution. Perfusion pressure and temperature were kept constant. Flow was measured with an infrared drop counter. Continuous recordings were made of heart rate, coronary flow, resting length, intraventricular pressure, force displacement and their first derivatives. Statistical analysis of all parameters before and during the perfusion with dantrolene sodium solution showed no significant changes for the same period of time. These results show that dantrolene sodium has no effect and do not confirm recent publications which reported a marked myocardial depression by dantrolene sodium.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-160-40384</identifier><identifier>PMID: 419123</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Central Venous Pressure - drug effects ; Dantrolene - adverse effects ; Heart - drug effects ; Heart Rate - drug effects ; Hydantoins - adverse effects ; Myocardial Contraction - drug effects ; Perfusion ; Rats ; Regional Blood Flow - drug effects</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1979-01, Vol.160 (1), p.42-45</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-3cb3c70efd0cd2e2d0cc254a3463e665c8ca7cc784098734cd47ffd1cb8609f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/419123$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gollan, Frank</creatorcontrib><creatorcontrib>McDermott, Joanne</creatorcontrib><title>Effect of the Skeletal Muscle Relaxant Dantrolene Sodium on the Isolated, Perfused Heart</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Summary
The literature indicates that dantrolene sodium has produced negligible cardiovascular changes in intact dogs and in patients, but caused depression in the isolated perfused heart. In nine consecutive experiments rat hearts were perfused by means of a modified Langendorff preparation with 3.5% bovine albumin in buffered, mammalian Ringer's solution. Perfusion pressure and temperature were kept constant. Flow was measured with an infrared drop counter. Continuous recordings were made of heart rate, coronary flow, resting length, intraventricular pressure, force displacement and their first derivatives. Statistical analysis of all parameters before and during the perfusion with dantrolene sodium solution showed no significant changes for the same period of time. These results show that dantrolene sodium has no effect and do not confirm recent publications which reported a marked myocardial depression by dantrolene sodium.</description><subject>Animals</subject><subject>Central Venous Pressure - drug effects</subject><subject>Dantrolene - adverse effects</subject><subject>Heart - drug effects</subject><subject>Heart Rate - drug effects</subject><subject>Hydantoins - adverse effects</subject><subject>Myocardial Contraction - drug effects</subject><subject>Perfusion</subject><subject>Rats</subject><subject>Regional Blood Flow - drug effects</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1OwzAQhC3EXym8AOLgB8DUjp04OaJSaKUiEPTALXLtNbSkcWU7Erw9LgGOXHYOOzPa_RA6Z_SKs5KNKOWykpkkrKBEUF6KPTRgOc8JL6pqHw12BrJzHKOTENaUslxmxRE6FKxiGR-gl4m1oCN2Fsc3wM_v0EBUDb7vgm4AP0GjPlQb8U0a3jXQJo8zq26DXfudmAXXqAjmEj-Ct10Ag6egfDxFB1Y1Ac5-dIgWt5PFeErmD3ez8fWc6HRvJFwvuZYUrKHaZJAl0VkuFBcFh6LIdamV1FqWglal5EIbIa01TC_LglaWD1HW12rvQvBg661fbZT_rBmtd4zqX0Z1YlR_M0qhiz607ZYbMH-RHkpaj_p1UK9Qr13n2_TBf4Vfs0pvjA</recordid><startdate>197901</startdate><enddate>197901</enddate><creator>Gollan, Frank</creator><creator>McDermott, Joanne</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>197901</creationdate><title>Effect of the Skeletal Muscle Relaxant Dantrolene Sodium on the Isolated, Perfused Heart</title><author>Gollan, Frank ; McDermott, Joanne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-3cb3c70efd0cd2e2d0cc254a3463e665c8ca7cc784098734cd47ffd1cb8609f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Animals</topic><topic>Central Venous Pressure - drug effects</topic><topic>Dantrolene - adverse effects</topic><topic>Heart - drug effects</topic><topic>Heart Rate - drug effects</topic><topic>Hydantoins - adverse effects</topic><topic>Myocardial Contraction - drug effects</topic><topic>Perfusion</topic><topic>Rats</topic><topic>Regional Blood Flow - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gollan, Frank</creatorcontrib><creatorcontrib>McDermott, Joanne</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gollan, Frank</au><au>McDermott, Joanne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of the Skeletal Muscle Relaxant Dantrolene Sodium on the Isolated, Perfused Heart</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1979-01</date><risdate>1979</risdate><volume>160</volume><issue>1</issue><spage>42</spage><epage>45</epage><pages>42-45</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary
The literature indicates that dantrolene sodium has produced negligible cardiovascular changes in intact dogs and in patients, but caused depression in the isolated perfused heart. In nine consecutive experiments rat hearts were perfused by means of a modified Langendorff preparation with 3.5% bovine albumin in buffered, mammalian Ringer's solution. Perfusion pressure and temperature were kept constant. Flow was measured with an infrared drop counter. Continuous recordings were made of heart rate, coronary flow, resting length, intraventricular pressure, force displacement and their first derivatives. Statistical analysis of all parameters before and during the perfusion with dantrolene sodium solution showed no significant changes for the same period of time. These results show that dantrolene sodium has no effect and do not confirm recent publications which reported a marked myocardial depression by dantrolene sodium.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>419123</pmid><doi>10.3181/00379727-160-40384</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1979-01, Vol.160 (1), p.42-45 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
| recordid | cdi_pubmed_primary_419123 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Central Venous Pressure - drug effects Dantrolene - adverse effects Heart - drug effects Heart Rate - drug effects Hydantoins - adverse effects Myocardial Contraction - drug effects Perfusion Rats Regional Blood Flow - drug effects |
| title | Effect of the Skeletal Muscle Relaxant Dantrolene Sodium on the Isolated, Perfused Heart |
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