The Immune Response to a Schistosomacide, Amoscanate Ii. Cell-Mediated Immune Responses
Abstract A potent antischistosomal drug, Amoscanate, was found to induce vigorous serum antibody responses when either fed or administered parenterally as a drug-protein conugate. Because of preliminary evidence that the drug could bind covalently to proteins in vivo, we decided to investigate the p...
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| Veröffentlicht in: | Immunopharmacology and immunotoxicology 1985, Vol.7 (3), p.373-383 |
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| container_end_page | 383 |
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| container_issue | 3 |
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| container_title | Immunopharmacology and immunotoxicology |
| container_volume | 7 |
| creator | Barton, B. E. Levy, D. A. |
| description | Abstract
A potent antischistosomal drug, Amoscanate, was found to induce vigorous serum antibody responses when either fed or administered parenterally as a drug-protein conugate. Because of preliminary evidence that the drug could bind covalently to proteins in vivo, we decided to investigate the possibility that the drug could act as a contact sensitizing agent like DNCB. It was found that Amoscanate could induce a delayed-type hypersensitivity (DTH) response when painted on the shaved skin of guinea pigs. Moreover, the type of DTH response elicited was found to be cutaneous basophilic hypersensitivity (CBH). The significance of these findings are discussed. |
| doi_str_mv | 10.3109/08923978509026482 |
| format | Article |
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A potent antischistosomal drug, Amoscanate, was found to induce vigorous serum antibody responses when either fed or administered parenterally as a drug-protein conugate. Because of preliminary evidence that the drug could bind covalently to proteins in vivo, we decided to investigate the possibility that the drug could act as a contact sensitizing agent like DNCB. It was found that Amoscanate could induce a delayed-type hypersensitivity (DTH) response when painted on the shaved skin of guinea pigs. Moreover, the type of DTH response elicited was found to be cutaneous basophilic hypersensitivity (CBH). The significance of these findings are discussed.</description><identifier>ISSN: 0892-3973</identifier><identifier>ISSN: 0163-0571</identifier><identifier>EISSN: 1532-2513</identifier><identifier>DOI: 10.3109/08923978509026482</identifier><identifier>PMID: 4056413</identifier><language>eng</language><publisher>New York, NY: Informa UK Ltd</publisher><subject>Aniline Compounds - immunology ; Animals ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiparasitic agents ; Biological and medical sciences ; Dermatitis, Contact - etiology ; Dinitrochlorobenzene ; Diphenylamine - analogs & derivatives ; Diphenylamine - immunology ; Guinea Pigs ; Immunity, Cellular ; Isothiocyanates ; Medical sciences ; Pharmacology. Drug treatments ; Schistosomicides - immunology ; Thiocyanates - immunology</subject><ispartof>Immunopharmacology and immunotoxicology, 1985, Vol.7 (3), p.373-383</ispartof><rights>1985 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1985</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c379t-ca40f9073464f18d1975ff88e9a393131936c2aea2eefb46ac527e388eb402e73</citedby><cites>FETCH-LOGICAL-c379t-ca40f9073464f18d1975ff88e9a393131936c2aea2eefb46ac527e388eb402e73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/08923978509026482$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/08923978509026482$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,4009,27902,27903,27904,59624,60413,61198,61233,61379,61414</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8406691$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4056413$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barton, B. E.</creatorcontrib><creatorcontrib>Levy, D. A.</creatorcontrib><title>The Immune Response to a Schistosomacide, Amoscanate Ii. Cell-Mediated Immune Responses</title><title>Immunopharmacology and immunotoxicology</title><addtitle>J Immunopharmacol</addtitle><description>Abstract
A potent antischistosomal drug, Amoscanate, was found to induce vigorous serum antibody responses when either fed or administered parenterally as a drug-protein conugate. Because of preliminary evidence that the drug could bind covalently to proteins in vivo, we decided to investigate the possibility that the drug could act as a contact sensitizing agent like DNCB. It was found that Amoscanate could induce a delayed-type hypersensitivity (DTH) response when painted on the shaved skin of guinea pigs. Moreover, the type of DTH response elicited was found to be cutaneous basophilic hypersensitivity (CBH). The significance of these findings are discussed.</description><subject>Aniline Compounds - immunology</subject><subject>Animals</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Dermatitis, Contact - etiology</subject><subject>Dinitrochlorobenzene</subject><subject>Diphenylamine - analogs & derivatives</subject><subject>Diphenylamine - immunology</subject><subject>Guinea Pigs</subject><subject>Immunity, Cellular</subject><subject>Isothiocyanates</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Schistosomicides - immunology</subject><subject>Thiocyanates - immunology</subject><issn>0892-3973</issn><issn>0163-0571</issn><issn>1532-2513</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAUhYMoOj5-gAuhC3FlNa-mDbqRwReMCDristxJb5hK24xJi_jvjcwoqOAqkPOdw7mHkH1GTwSj-pQWmgudFxnVlCtZ8DUyYpngKc-YWCejTz2NgNgi2yG8UMp0TrNNsilppiQTI_I8nWNy27ZDh8kDhoXrAia9SyB5NPM69C64Fkxd4XFy0bpgoIM-GuqTZIxNk95hVceP6ndE2CUbFpqAe6t3hzxdXU7HN-nk_vp2fDFJjch1nxqQ1GqaC6mkZUUV-2XWFgVqEFowwbRQhgMCR7QzqcBkPEcRgZmkHHOxQ46WuQvvXgcMfdnWwcRq0KEbQpkrKThTNIJsCRrvQvBoy4WvW_DvJaPl55jlnzGj52AVPsxarL4dq_WifrjSIS7TWA-dqcM3VkiqlGYRO19idWedb-HN-aYqe3hvnP_yiP9anP2wzxGafm7AY_niBt_Fef-54QP73aBC</recordid><startdate>1985</startdate><enddate>1985</enddate><creator>Barton, B. E.</creator><creator>Levy, D. A.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Dekker</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1985</creationdate><title>The Immune Response to a Schistosomacide, Amoscanate Ii. Cell-Mediated Immune Responses</title><author>Barton, B. E. ; Levy, D. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-ca40f9073464f18d1975ff88e9a393131936c2aea2eefb46ac527e388eb402e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Aniline Compounds - immunology</topic><topic>Animals</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Dermatitis, Contact - etiology</topic><topic>Dinitrochlorobenzene</topic><topic>Diphenylamine - analogs & derivatives</topic><topic>Diphenylamine - immunology</topic><topic>Guinea Pigs</topic><topic>Immunity, Cellular</topic><topic>Isothiocyanates</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Schistosomicides - immunology</topic><topic>Thiocyanates - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barton, B. E.</creatorcontrib><creatorcontrib>Levy, D. A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Immunopharmacology and immunotoxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barton, B. E.</au><au>Levy, D. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Immune Response to a Schistosomacide, Amoscanate Ii. Cell-Mediated Immune Responses</atitle><jtitle>Immunopharmacology and immunotoxicology</jtitle><addtitle>J Immunopharmacol</addtitle><date>1985</date><risdate>1985</risdate><volume>7</volume><issue>3</issue><spage>373</spage><epage>383</epage><pages>373-383</pages><issn>0892-3973</issn><issn>0163-0571</issn><eissn>1532-2513</eissn><abstract>Abstract
A potent antischistosomal drug, Amoscanate, was found to induce vigorous serum antibody responses when either fed or administered parenterally as a drug-protein conugate. Because of preliminary evidence that the drug could bind covalently to proteins in vivo, we decided to investigate the possibility that the drug could act as a contact sensitizing agent like DNCB. It was found that Amoscanate could induce a delayed-type hypersensitivity (DTH) response when painted on the shaved skin of guinea pigs. Moreover, the type of DTH response elicited was found to be cutaneous basophilic hypersensitivity (CBH). The significance of these findings are discussed.</abstract><cop>New York, NY</cop><pub>Informa UK Ltd</pub><pmid>4056413</pmid><doi>10.3109/08923978509026482</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0892-3973 |
| ispartof | Immunopharmacology and immunotoxicology, 1985, Vol.7 (3), p.373-383 |
| issn | 0892-3973 0163-0571 1532-2513 |
| language | eng |
| recordid | cdi_pubmed_primary_4056413 |
| source | Taylor & Francis Online; MEDLINE; Taylor & Francis Medical Library - CRKN |
| subjects | Aniline Compounds - immunology Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Biological and medical sciences Dermatitis, Contact - etiology Dinitrochlorobenzene Diphenylamine - analogs & derivatives Diphenylamine - immunology Guinea Pigs Immunity, Cellular Isothiocyanates Medical sciences Pharmacology. Drug treatments Schistosomicides - immunology Thiocyanates - immunology |
| title | The Immune Response to a Schistosomacide, Amoscanate Ii. Cell-Mediated Immune Responses |
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