Activity of a novel 4-quinolinecarboxylic acid, NSC 368390 [6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinolinecarboxylic acid sodium salt], against experimental tumors

A novel, substituted 4-quinolinecarboxylic acid (NSC 339768) demonstrated antitumor activity against L1210 leukemia and B16 melanoma in the National Cancer Institute's Developmental Therapeutics Program. An extensive analogue synthesis program was initiated; over 200 derivatives were synthesize...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1985-11, Vol.45 (11), p.5563-5568
Hauptverfasser:	DEXTER, D. L, HESSON, D. P, FORBES, M, ARDECKY, R. J, RAO, G. V, TIPPETT, D. L, DUSAK, B. A, PAULL, K. D, PLOWMAN, J, DELARCO, B. M, NARAYANAN, V. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimetabolites - pharmacology Antineoplastic agents Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Biological and medical sciences Biphenyl Compounds - therapeutic use Chemotherapy Colonic Neoplasms - drug therapy Female Lung Neoplasms - drug therapy Male Medical sciences Mice Mice, Inbred BALB C Mice, Inbred DBA Neoplasm Transplantation Neoplasms, Experimental - drug therapy Pharmacology. Drug treatments Transplantation, Heterologous
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