Radiation in bone sarcomas. A re‐evaluation in the era of intensive systemic chemotherapy
We have reviewed the literature and described experience in treating Ewing's sarcoma and osteosarcoma before and during the era of intensive systemic chemotherapy. Local control of Ewing's sarcoma may relate to increasing doses of radiation, especially when intensive chemotherapy is admini...
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| Veröffentlicht in: | Cancer 1977-02, Vol.39 (S2), p.806-816 |
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| container_end_page | 816 |
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| container_issue | S2 |
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| container_title | Cancer |
| container_volume | 39 |
| creator | Tefft, Melvin Mc Chabora, Beryl C. Rosen, Gerald |
| description | We have reviewed the literature and described experience in treating Ewing's sarcoma and osteosarcoma before and during the era of intensive systemic chemotherapy. Local control of Ewing's sarcoma may relate to increasing doses of radiation, especially when intensive chemotherapy is administered also. Problems of radiation enhancement by chemotherapy have caused us to reconsider time‐dose and volume parameters in treating these patients. The role of radiation in osteogenic sarcoma is limited to patients with inoperable lesions and metastases. |
| doi_str_mv | 10.1002/1097-0142(197702)39:2+<806::AID-CNCR2820390715>3.0.CO;2-X |
| format | Article |
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The role of radiation in osteogenic sarcoma is limited to patients with inoperable lesions and metastases.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(197702)39:2+<806::AID-CNCR2820390715>3.0.CO;2-X</identifier><identifier>PMID: 402197</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Bone Neoplasms - drug therapy ; Bone Neoplasms - radiotherapy ; Bone Neoplasms - surgery ; Child ; Cyclophosphamide - therapeutic use ; Dactinomycin - therapeutic use ; Doxorubicin - therapeutic use ; Drug Therapy, Combination ; Humans ; Leucovorin - therapeutic use ; Lung Neoplasms - radiotherapy ; Methotrexate - therapeutic use ; Neoplasm Metastasis ; Osteosarcoma - drug therapy ; Osteosarcoma - radiotherapy ; Osteosarcoma - surgery ; Radiation Tolerance ; Radiotherapy Dosage ; Radiotherapy, High-Energy ; Sarcoma, Ewing - drug therapy ; Sarcoma, Ewing - radiotherapy ; Sarcoma, Ewing - surgery ; Vincristine - therapeutic use</subject><ispartof>Cancer, 1977-02, Vol.39 (S2), p.806-816</ispartof><rights>Copyright © 1977 American Cancer Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/402197$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tefft, Melvin</creatorcontrib><creatorcontrib>Mc Chabora, Beryl C.</creatorcontrib><creatorcontrib>Rosen, Gerald</creatorcontrib><title>Radiation in bone sarcomas. 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A re‐evaluation in the era of intensive systemic chemotherapy</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1977-02</date><risdate>1977</risdate><volume>39</volume><issue>S2</issue><spage>806</spage><epage>816</epage><pages>806-816</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><abstract>We have reviewed the literature and described experience in treating Ewing's sarcoma and osteosarcoma before and during the era of intensive systemic chemotherapy. Local control of Ewing's sarcoma may relate to increasing doses of radiation, especially when intensive chemotherapy is administered also. Problems of radiation enhancement by chemotherapy have caused us to reconsider time‐dose and volume parameters in treating these patients. The role of radiation in osteogenic sarcoma is limited to patients with inoperable lesions and metastases.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>402197</pmid><doi>10.1002/1097-0142(197702)39:2+<806::AID-CNCR2820390715>3.0.CO;2-X</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0008-543X |
| ispartof | Cancer, 1977-02, Vol.39 (S2), p.806-816 |
| issn | 0008-543X 1097-0142 |
| language | eng |
| recordid | cdi_pubmed_primary_402197 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Bone Neoplasms - drug therapy Bone Neoplasms - radiotherapy Bone Neoplasms - surgery Child Cyclophosphamide - therapeutic use Dactinomycin - therapeutic use Doxorubicin - therapeutic use Drug Therapy, Combination Humans Leucovorin - therapeutic use Lung Neoplasms - radiotherapy Methotrexate - therapeutic use Neoplasm Metastasis Osteosarcoma - drug therapy Osteosarcoma - radiotherapy Osteosarcoma - surgery Radiation Tolerance Radiotherapy Dosage Radiotherapy, High-Energy Sarcoma, Ewing - drug therapy Sarcoma, Ewing - radiotherapy Sarcoma, Ewing - surgery Vincristine - therapeutic use |
| title | Radiation in bone sarcomas. A re‐evaluation in the era of intensive systemic chemotherapy |
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