Inhibition of Carcinogenic Effects of Polycyclic Hydrocarbons by Benzyl Isothiocyanate and Related Compounds
Benzyl isothiocyanate and phenethyl isothiocyanate, two compounds found in cruciferous plants, and phenyl isothiocyanate, a synthetic compound, all inhibit 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumor formation in female Sprague-Dawley rats when administered 4 hours prior to the DMBA....
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| Veröffentlicht in: | JNCI : Journal of the National Cancer Institute 1977-02, Vol.58 (2), p.395-398 |
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| container_title | JNCI : Journal of the National Cancer Institute |
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| creator | Wattenberg, L W |
| description | Benzyl isothiocyanate and phenethyl isothiocyanate, two compounds found in cruciferous plants, and phenyl isothiocyanate, a synthetic compound, all inhibit 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumor formation in female Sprague-Dawley rats when administered 4 hours prior to the DMBA. Comparable studies in which benzyl isothiocyanate was administered 24 hours before or 4 hours after DMBA showed almost complete loss of inhibition. Additions of benzyl isothiocyanate or phenethyl isothiocyanate to a diet containing DMBA inhibited formation of neoplasms of the forestomach and pulmonary adenomas in female ICR/Ha mice. Addition of benzyl isothiocyanate to a diet containing benzo[a]pyrene also inhibited carcinogenesis of the mouse forestomach due to this carcinogen. The finding of two additional anutrient dietary compounds which inhibit chemical carcinogenesis focuses on the possibility that dietary constituents of this nature may diminish the impact of exposures to chemical carcinogens. |
| doi_str_mv | 10.1093/jnci/58.2.395 |
| format | Article |
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Comparable studies in which benzyl isothiocyanate was administered 24 hours before or 4 hours after DMBA showed almost complete loss of inhibition. Additions of benzyl isothiocyanate or phenethyl isothiocyanate to a diet containing DMBA inhibited formation of neoplasms of the forestomach and pulmonary adenomas in female ICR/Ha mice. Addition of benzyl isothiocyanate to a diet containing benzo[a]pyrene also inhibited carcinogenesis of the mouse forestomach due to this carcinogen. The finding of two additional anutrient dietary compounds which inhibit chemical carcinogenesis focuses on the possibility that dietary constituents of this nature may diminish the impact of exposures to chemical carcinogens.</description><identifier>ISSN: 0027-8874</identifier><identifier>EISSN: 1460-2105</identifier><identifier>DOI: 10.1093/jnci/58.2.395</identifier><identifier>PMID: 401894</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>9,10-Dimethyl-1,2-benzanthracene - antagonists & inhibitors ; Administration, Oral ; Animals ; Benz(a)Anthracenes - antagonists & inhibitors ; Benzopyrenes - antagonists & inhibitors ; Diet ; Drug Administration Schedule ; Female ; Mammary Neoplasms, Experimental - chemically induced ; Mice ; Mice, Inbred ICR ; Neoplasms, Experimental - chemically induced ; Rats ; Stomach Neoplasms - chemically induced ; Thiocyanates - administration & dosage ; Thiocyanates - pharmacology</subject><ispartof>JNCI : Journal of the National Cancer Institute, 1977-02, Vol.58 (2), p.395-398</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/401894$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wattenberg, L W</creatorcontrib><title>Inhibition of Carcinogenic Effects of Polycyclic Hydrocarbons by Benzyl Isothiocyanate and Related Compounds</title><title>JNCI : Journal of the National Cancer Institute</title><addtitle>Journal of the National Cancer Institute</addtitle><description>Benzyl isothiocyanate and phenethyl isothiocyanate, two compounds found in cruciferous plants, and phenyl isothiocyanate, a synthetic compound, all inhibit 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumor formation in female Sprague-Dawley rats when administered 4 hours prior to the DMBA. Comparable studies in which benzyl isothiocyanate was administered 24 hours before or 4 hours after DMBA showed almost complete loss of inhibition. Additions of benzyl isothiocyanate or phenethyl isothiocyanate to a diet containing DMBA inhibited formation of neoplasms of the forestomach and pulmonary adenomas in female ICR/Ha mice. Addition of benzyl isothiocyanate to a diet containing benzo[a]pyrene also inhibited carcinogenesis of the mouse forestomach due to this carcinogen. The finding of two additional anutrient dietary compounds which inhibit chemical carcinogenesis focuses on the possibility that dietary constituents of this nature may diminish the impact of exposures to chemical carcinogens.</description><subject>9,10-Dimethyl-1,2-benzanthracene - antagonists & inhibitors</subject><subject>Administration, Oral</subject><subject>Animals</subject><subject>Benz(a)Anthracenes - antagonists & inhibitors</subject><subject>Benzopyrenes - antagonists & inhibitors</subject><subject>Diet</subject><subject>Drug Administration Schedule</subject><subject>Female</subject><subject>Mammary Neoplasms, Experimental - chemically induced</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Neoplasms, Experimental - chemically induced</subject><subject>Rats</subject><subject>Stomach Neoplasms - chemically induced</subject><subject>Thiocyanates - administration & dosage</subject><subject>Thiocyanates - pharmacology</subject><issn>0027-8874</issn><issn>1460-2105</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j11LwzAUhoP4NaeX3nmRP9Dt5KtpL3VubjBUREF2U5I0dZldMpoOrL_eysRz8x6eBw7nReiawIhAzsYbb9xYZCM6Yrk4QgPCU0goAXGMBgBUJlkm-Tm6iHED_eSUn6FTDiTL-QDVC7922rUueBwqPFGNcT58WO8MnlaVNW385c-h7kxn6p7Ou7IJRjU6-Ih1h--s_-5qvIihXbtgOuVVa7HyJX6xdb-WeBK2u7D3ZbxEJ5Wqo736yyF6m01fJ_Nk-fSwmNwuE0c5axNmLGQGiE4JMF4Ck4RK0FSLPDOapaL_nJkq0yANM3nOJVO2olXJJUgqFRuim8Pd3V5vbVnsGrdVTVccSvc6OWgXW_v1b1XzWaSSSVHM31cFvReCzh6XxYr9AAfJaQw</recordid><startdate>197702</startdate><enddate>197702</enddate><creator>Wattenberg, L W</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>197702</creationdate><title>Inhibition of Carcinogenic Effects of Polycyclic Hydrocarbons by Benzyl Isothiocyanate and Related Compounds</title><author>Wattenberg, L W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i243t-3ce08c01b61034d0371270b2b598cb3658943cf8b07c3c99473aef2fd470727a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>9,10-Dimethyl-1,2-benzanthracene - antagonists & inhibitors</topic><topic>Administration, Oral</topic><topic>Animals</topic><topic>Benz(a)Anthracenes - antagonists & inhibitors</topic><topic>Benzopyrenes - antagonists & inhibitors</topic><topic>Diet</topic><topic>Drug Administration Schedule</topic><topic>Female</topic><topic>Mammary Neoplasms, Experimental - chemically induced</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Neoplasms, Experimental - chemically induced</topic><topic>Rats</topic><topic>Stomach Neoplasms - chemically induced</topic><topic>Thiocyanates - administration & dosage</topic><topic>Thiocyanates - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wattenberg, L W</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>JNCI : Journal of the National Cancer Institute</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wattenberg, L W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of Carcinogenic Effects of Polycyclic Hydrocarbons by Benzyl Isothiocyanate and Related Compounds</atitle><jtitle>JNCI : Journal of the National Cancer Institute</jtitle><addtitle>Journal of the National Cancer Institute</addtitle><date>1977-02</date><risdate>1977</risdate><volume>58</volume><issue>2</issue><spage>395</spage><epage>398</epage><pages>395-398</pages><issn>0027-8874</issn><eissn>1460-2105</eissn><abstract>Benzyl isothiocyanate and phenethyl isothiocyanate, two compounds found in cruciferous plants, and phenyl isothiocyanate, a synthetic compound, all inhibit 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumor formation in female Sprague-Dawley rats when administered 4 hours prior to the DMBA. Comparable studies in which benzyl isothiocyanate was administered 24 hours before or 4 hours after DMBA showed almost complete loss of inhibition. Additions of benzyl isothiocyanate or phenethyl isothiocyanate to a diet containing DMBA inhibited formation of neoplasms of the forestomach and pulmonary adenomas in female ICR/Ha mice. Addition of benzyl isothiocyanate to a diet containing benzo[a]pyrene also inhibited carcinogenesis of the mouse forestomach due to this carcinogen. The finding of two additional anutrient dietary compounds which inhibit chemical carcinogenesis focuses on the possibility that dietary constituents of this nature may diminish the impact of exposures to chemical carcinogens.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>401894</pmid><doi>10.1093/jnci/58.2.395</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0027-8874 |
| ispartof | JNCI : Journal of the National Cancer Institute, 1977-02, Vol.58 (2), p.395-398 |
| issn | 0027-8874 1460-2105 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | 9,10-Dimethyl-1,2-benzanthracene - antagonists & inhibitors Administration, Oral Animals Benz(a)Anthracenes - antagonists & inhibitors Benzopyrenes - antagonists & inhibitors Diet Drug Administration Schedule Female Mammary Neoplasms, Experimental - chemically induced Mice Mice, Inbred ICR Neoplasms, Experimental - chemically induced Rats Stomach Neoplasms - chemically induced Thiocyanates - administration & dosage Thiocyanates - pharmacology |
| title | Inhibition of Carcinogenic Effects of Polycyclic Hydrocarbons by Benzyl Isothiocyanate and Related Compounds |
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