POSSIBLE PARTICIPATION OF CHOLESTATIC FACTOR IN THE PATHOGENESIS OF INTRAHEPATIC CHOLESTASIS IN ALCOHOLIC LIVER DISEASE
To elucidate the immunopathogenesis of intrahepatic cholestasis in alcoholic liver disease, the authors investigated the possible participation of cholestatic factor. The peripheral lymphocytes from patients with intrahepatic cholestasis in alcoholic liver disease were stimulated with ethanol and li...
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| Veröffentlicht in: | Nippon Shokakibyo Gakkai Zasshi 1985, Vol.82(3), pp.441-449 |
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| container_title | Nippon Shokakibyo Gakkai Zasshi |
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| creator | MIZOGUCHI, Yasuhiro KATOH, Hiroko TSUTSUI, Hiroko MIYAJIMA, Keiji ARAI, Takayuki SAKAGAMI, Yoshihide HIGASHIMORI, Toshihiro HARIHARA, Shigeyoshi YAMAMOTO, Sukeo MONNA, Takeyuki HONDA, Yoshihiro MORISAWA, Seiji |
| description | To elucidate the immunopathogenesis of intrahepatic cholestasis in alcoholic liver disease, the authors investigated the possible participation of cholestatic factor. The peripheral lymphocytes from patients with intrahepatic cholestasis in alcoholic liver disease were stimulated with ethanol and liver specific lipoprotein in vitro and the cluture supernatant was fractionated by gel filtration using a Sephadex G-75 column. When a definitive fraction (fraction 4) was injected into the mesenteric vein of rats, a marked reduction of bile flow was observed. Similar results were obtained when blood serum of patients was fractionated in an identical manner and the same fraction was injected to rats via mesenteric vein. Histologically, a dilated bile canaliculus with the diminution of microvilli and increased vesicles around the dilated canaliculi were observed by an electron microscopy after injection of the active fraction into rats. These results strongly suggest that not only the sensitized lymphocytes produce the cholestatic factor(s) which caused the intrahepatic cholestasis by specific stimulation, but also this factor involves significantly in the pathogenesis of intrahepatic cholestasis which observed in the patients with intrahepatic cholestasis in alcoholic liver disease. |
| doi_str_mv | 10.11405/nisshoshi1964.82.441 |
| format | Article |
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The peripheral lymphocytes from patients with intrahepatic cholestasis in alcoholic liver disease were stimulated with ethanol and liver specific lipoprotein in vitro and the cluture supernatant was fractionated by gel filtration using a Sephadex G-75 column. When a definitive fraction (fraction 4) was injected into the mesenteric vein of rats, a marked reduction of bile flow was observed. Similar results were obtained when blood serum of patients was fractionated in an identical manner and the same fraction was injected to rats via mesenteric vein. Histologically, a dilated bile canaliculus with the diminution of microvilli and increased vesicles around the dilated canaliculi were observed by an electron microscopy after injection of the active fraction into rats. These results strongly suggest that not only the sensitized lymphocytes produce the cholestatic factor(s) which caused the intrahepatic cholestasis by specific stimulation, but also this factor involves significantly in the pathogenesis of intrahepatic cholestasis which observed in the patients with intrahepatic cholestasis in alcoholic liver disease.</description><identifier>ISSN: 0446-6586</identifier><identifier>EISSN: 1349-7693</identifier><identifier>DOI: 10.11405/nisshoshi1964.82.441</identifier><identifier>PMID: 4010012</identifier><language>jpn</language><publisher>Japan: The Japanese Society of Gastroenterology</publisher><subject>Adult ; Animals ; Cholestasis, Intrahepatic - etiology ; Cholestasis, Intrahepatic - immunology ; Humans ; Liver Diseases, Alcoholic - complications ; Liver Diseases, Alcoholic - immunology ; Lymphokines - physiology ; Male ; Middle Aged ; Rats ; Rats, Inbred Strains</subject><ispartof>Nippon Shokakibyo Gakkai Zasshi, 1985, Vol.82(3), pp.441-449</ispartof><rights>The Japanese Society of Gastroenterology</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4010012$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MIZOGUCHI, Yasuhiro</creatorcontrib><creatorcontrib>KATOH, Hiroko</creatorcontrib><creatorcontrib>TSUTSUI, Hiroko</creatorcontrib><creatorcontrib>MIYAJIMA, Keiji</creatorcontrib><creatorcontrib>ARAI, Takayuki</creatorcontrib><creatorcontrib>SAKAGAMI, Yoshihide</creatorcontrib><creatorcontrib>HIGASHIMORI, Toshihiro</creatorcontrib><creatorcontrib>HARIHARA, Shigeyoshi</creatorcontrib><creatorcontrib>YAMAMOTO, Sukeo</creatorcontrib><creatorcontrib>MONNA, Takeyuki</creatorcontrib><creatorcontrib>HONDA, Yoshihiro</creatorcontrib><creatorcontrib>MORISAWA, Seiji</creatorcontrib><title>POSSIBLE PARTICIPATION OF CHOLESTATIC FACTOR IN THE PATHOGENESIS OF INTRAHEPATIC CHOLESTASIS IN ALCOHOLIC LIVER DISEASE</title><title>Nippon Shokakibyo Gakkai Zasshi</title><addtitle>Nippon Shokakibyo Gakkai Zasshi</addtitle><description>To elucidate the immunopathogenesis of intrahepatic cholestasis in alcoholic liver disease, the authors investigated the possible participation of cholestatic factor. The peripheral lymphocytes from patients with intrahepatic cholestasis in alcoholic liver disease were stimulated with ethanol and liver specific lipoprotein in vitro and the cluture supernatant was fractionated by gel filtration using a Sephadex G-75 column. When a definitive fraction (fraction 4) was injected into the mesenteric vein of rats, a marked reduction of bile flow was observed. Similar results were obtained when blood serum of patients was fractionated in an identical manner and the same fraction was injected to rats via mesenteric vein. Histologically, a dilated bile canaliculus with the diminution of microvilli and increased vesicles around the dilated canaliculi were observed by an electron microscopy after injection of the active fraction into rats. These results strongly suggest that not only the sensitized lymphocytes produce the cholestatic factor(s) which caused the intrahepatic cholestasis by specific stimulation, but also this factor involves significantly in the pathogenesis of intrahepatic cholestasis which observed in the patients with intrahepatic cholestasis in alcoholic liver disease.</description><subject>Adult</subject><subject>Animals</subject><subject>Cholestasis, Intrahepatic - etiology</subject><subject>Cholestasis, Intrahepatic - immunology</subject><subject>Humans</subject><subject>Liver Diseases, Alcoholic - complications</subject><subject>Liver Diseases, Alcoholic - immunology</subject><subject>Lymphokines - physiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0446-6586</issn><issn>1349-7693</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkN1ugkAQRjdNG2usj2DCC2D3D9i9pHSVTQhLYNtbsotQMWoN2Ji-fbFak97MZOacmYsPgBmCc4Qo9J73bd-vP_t1i7hP5wzPKUV3YIwI5W7gc3IPxpBS3_U95j-Cad-3FkLIPc4IGYERhQhChMfglKmikC-JcLIw1zKSWailSh21cKJYJaLQwxw5izDSKndk6uj4rOpYLUUqClmcTZnqPIxF9qv-nZ3Z4IdJpIbNABL5LnLnVRYiLMQTeGjMtq-n1z4Bbwuho9hN1FJGYeJuMKVH11a2wQ21VWAtXnEvsMSsjEcMJdAi7EHEEcOB5dRyjBmqKs6amlmPGr9GlpMJmF3-Hr7srl6Vh67dme67vAYwcHnhm_5oPuobN92xrbZ1-S_nkuGSXMoQ982p1qYr6z35AaYvcZ4</recordid><startdate>1985</startdate><enddate>1985</enddate><creator>MIZOGUCHI, Yasuhiro</creator><creator>KATOH, Hiroko</creator><creator>TSUTSUI, Hiroko</creator><creator>MIYAJIMA, Keiji</creator><creator>ARAI, Takayuki</creator><creator>SAKAGAMI, Yoshihide</creator><creator>HIGASHIMORI, Toshihiro</creator><creator>HARIHARA, Shigeyoshi</creator><creator>YAMAMOTO, Sukeo</creator><creator>MONNA, Takeyuki</creator><creator>HONDA, Yoshihiro</creator><creator>MORISAWA, Seiji</creator><general>The Japanese Society of Gastroenterology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>1985</creationdate><title>POSSIBLE PARTICIPATION OF CHOLESTATIC FACTOR IN THE PATHOGENESIS OF INTRAHEPATIC CHOLESTASIS IN ALCOHOLIC LIVER DISEASE</title><author>MIZOGUCHI, Yasuhiro ; KATOH, Hiroko ; TSUTSUI, Hiroko ; MIYAJIMA, Keiji ; ARAI, Takayuki ; SAKAGAMI, Yoshihide ; HIGASHIMORI, Toshihiro ; HARIHARA, Shigeyoshi ; YAMAMOTO, Sukeo ; MONNA, Takeyuki ; HONDA, Yoshihiro ; MORISAWA, Seiji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j244t-bcbf2f4bc7bb2d957b3ada53a430b1250191827b94b92281cc98fe8b54a6e1b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1985</creationdate><topic>Adult</topic><topic>Animals</topic><topic>Cholestasis, Intrahepatic - etiology</topic><topic>Cholestasis, Intrahepatic - immunology</topic><topic>Humans</topic><topic>Liver Diseases, Alcoholic - complications</topic><topic>Liver Diseases, Alcoholic - immunology</topic><topic>Lymphokines - physiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>online_resources</toplevel><creatorcontrib>MIZOGUCHI, Yasuhiro</creatorcontrib><creatorcontrib>KATOH, Hiroko</creatorcontrib><creatorcontrib>TSUTSUI, Hiroko</creatorcontrib><creatorcontrib>MIYAJIMA, Keiji</creatorcontrib><creatorcontrib>ARAI, Takayuki</creatorcontrib><creatorcontrib>SAKAGAMI, Yoshihide</creatorcontrib><creatorcontrib>HIGASHIMORI, Toshihiro</creatorcontrib><creatorcontrib>HARIHARA, Shigeyoshi</creatorcontrib><creatorcontrib>YAMAMOTO, Sukeo</creatorcontrib><creatorcontrib>MONNA, Takeyuki</creatorcontrib><creatorcontrib>HONDA, Yoshihiro</creatorcontrib><creatorcontrib>MORISAWA, Seiji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Nippon Shokakibyo Gakkai Zasshi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MIZOGUCHI, Yasuhiro</au><au>KATOH, Hiroko</au><au>TSUTSUI, Hiroko</au><au>MIYAJIMA, Keiji</au><au>ARAI, Takayuki</au><au>SAKAGAMI, Yoshihide</au><au>HIGASHIMORI, Toshihiro</au><au>HARIHARA, Shigeyoshi</au><au>YAMAMOTO, Sukeo</au><au>MONNA, Takeyuki</au><au>HONDA, Yoshihiro</au><au>MORISAWA, Seiji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>POSSIBLE PARTICIPATION OF CHOLESTATIC FACTOR IN THE PATHOGENESIS OF INTRAHEPATIC CHOLESTASIS IN ALCOHOLIC LIVER DISEASE</atitle><jtitle>Nippon Shokakibyo Gakkai Zasshi</jtitle><addtitle>Nippon Shokakibyo Gakkai Zasshi</addtitle><date>1985</date><risdate>1985</risdate><volume>82</volume><issue>3</issue><spage>441</spage><epage>449</epage><pages>441-449</pages><issn>0446-6586</issn><eissn>1349-7693</eissn><abstract>To elucidate the immunopathogenesis of intrahepatic cholestasis in alcoholic liver disease, the authors investigated the possible participation of cholestatic factor. The peripheral lymphocytes from patients with intrahepatic cholestasis in alcoholic liver disease were stimulated with ethanol and liver specific lipoprotein in vitro and the cluture supernatant was fractionated by gel filtration using a Sephadex G-75 column. When a definitive fraction (fraction 4) was injected into the mesenteric vein of rats, a marked reduction of bile flow was observed. Similar results were obtained when blood serum of patients was fractionated in an identical manner and the same fraction was injected to rats via mesenteric vein. Histologically, a dilated bile canaliculus with the diminution of microvilli and increased vesicles around the dilated canaliculi were observed by an electron microscopy after injection of the active fraction into rats. These results strongly suggest that not only the sensitized lymphocytes produce the cholestatic factor(s) which caused the intrahepatic cholestasis by specific stimulation, but also this factor involves significantly in the pathogenesis of intrahepatic cholestasis which observed in the patients with intrahepatic cholestasis in alcoholic liver disease.</abstract><cop>Japan</cop><pub>The Japanese Society of Gastroenterology</pub><pmid>4010012</pmid><doi>10.11405/nisshoshi1964.82.441</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0446-6586 |
| ispartof | Nippon Shokakibyo Gakkai Zasshi, 1985, Vol.82(3), pp.441-449 |
| issn | 0446-6586 1349-7693 |
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| recordid | cdi_pubmed_primary_4010012 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Animals Cholestasis, Intrahepatic - etiology Cholestasis, Intrahepatic - immunology Humans Liver Diseases, Alcoholic - complications Liver Diseases, Alcoholic - immunology Lymphokines - physiology Male Middle Aged Rats Rats, Inbred Strains |
| title | POSSIBLE PARTICIPATION OF CHOLESTATIC FACTOR IN THE PATHOGENESIS OF INTRAHEPATIC CHOLESTASIS IN ALCOHOLIC LIVER DISEASE |
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