Further studies on the mechanism of fat-free diet (FFD): protection against indomethacin-induced intestinal ulcers in the rat (42072)
Abstract A fat-free diet (FFD) reduces bacterial flora when compared to a regular diet (RD) in rats. FFD reduces the degree and incidence of indomethacin-induced intestinal ulceration concomitantly with a reduction in bacterial flora overgrowth produced by the drug. Present and previous findings ind...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1985-05, Vol.179 (1), p.113-115 |
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| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 179 |
| creator | Evangelista, S. Ciappi, R. Ortolani, C. Barzanti, A. Meli, A. |
| description | Abstract
A fat-free diet (FFD) reduces bacterial flora when compared to a regular diet (RD) in rats. FFD reduces the degree and incidence of indomethacin-induced intestinal ulceration concomitantly with a reduction in bacterial flora overgrowth produced by the drug. Present and previous findings indicate that diminished deconjugation of indomethacin and reduction of intestinal flora overgrowth play a major role in the ulcer-preventing properties of FFD. |
| doi_str_mv | 10.3181/00379727-179-42072 |
| format | Article |
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A fat-free diet (FFD) reduces bacterial flora when compared to a regular diet (RD) in rats. FFD reduces the degree and incidence of indomethacin-induced intestinal ulceration concomitantly with a reduction in bacterial flora overgrowth produced by the drug. Present and previous findings indicate that diminished deconjugation of indomethacin and reduction of intestinal flora overgrowth play a major role in the ulcer-preventing properties of FFD.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1525-1373</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-179-42072</identifier><identifier>PMID: 3991592</identifier><identifier>CODEN: PSEBAA</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Biological and medical sciences ; Dietary Fats - administration & dosage ; digestive system diseases ; Drug toxicity and drugs side effects treatment ; enfermedades sistema digestivo ; indometacina ; indomethacin ; Indomethacin - metabolism ; Indomethacin - toxicity ; indomethacine ; Intestinal Diseases - chemically induced ; Intestinal Diseases - microbiology ; Intestinal Diseases - prevention & control ; Intestines - microbiology ; maladie de l' appareil digestif ; Male ; Medical sciences ; Pharmacology. Drug treatments ; rat ; rata ; Rats ; Rats, Inbred Strains ; Toxicity: digestive system ; Ulcer - chemically induced ; Ulcer - microbiology ; Ulcer - prevention & control</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1985-05, Vol.179 (1), p.113-115</ispartof><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-e7f33193b92928a171da05bde6d4725d700050e54e4c6fe22df65e9e8c10b7d23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7957747$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3991592$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Evangelista, S.</creatorcontrib><creatorcontrib>Ciappi, R.</creatorcontrib><creatorcontrib>Ortolani, C.</creatorcontrib><creatorcontrib>Barzanti, A.</creatorcontrib><creatorcontrib>Meli, A.</creatorcontrib><creatorcontrib>AgV Arbeitsgemeinschaft der Verbraucher e.V., Bonn (Germany, F.R.)</creatorcontrib><title>Further studies on the mechanism of fat-free diet (FFD): protection against indomethacin-induced intestinal ulcers in the rat (42072)</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Abstract
A fat-free diet (FFD) reduces bacterial flora when compared to a regular diet (RD) in rats. FFD reduces the degree and incidence of indomethacin-induced intestinal ulceration concomitantly with a reduction in bacterial flora overgrowth produced by the drug. Present and previous findings indicate that diminished deconjugation of indomethacin and reduction of intestinal flora overgrowth play a major role in the ulcer-preventing properties of FFD.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Dietary Fats - administration & dosage</subject><subject>digestive system diseases</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>enfermedades sistema digestivo</subject><subject>indometacina</subject><subject>indomethacin</subject><subject>Indomethacin - metabolism</subject><subject>Indomethacin - toxicity</subject><subject>indomethacine</subject><subject>Intestinal Diseases - chemically induced</subject><subject>Intestinal Diseases - microbiology</subject><subject>Intestinal Diseases - prevention & control</subject><subject>Intestines - microbiology</subject><subject>maladie de l' appareil digestif</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>rat</subject><subject>rata</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Toxicity: digestive system</subject><subject>Ulcer - chemically induced</subject><subject>Ulcer - microbiology</subject><subject>Ulcer - prevention & control</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1525-1373</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtuFDEQRS0ECpPADyCBvGBBFk78aLfb7FBgEqRIWUDWrRq7PONountkuxf5AP4bz4MsWZWq6tx6XEI-CH6lRCeuOVfGGmmYMJY1khv5iiyElpoJZdRrstgDbE-8Jec5P3HOWy75GTlT1gpt5YL8Wc6pbDDRXGYfMdNppDWnA7oNjDEPdAo0QGEhIdJKFPplufx--ZXu0lTQlVgFsIY45kLj6KcBywZcHFlNZoe-FgvmEkfY0nnrMOVaOaxIUGcdrr58R94E2GZ8f4oX5HH54_fNHbt_uP158-2euUa3haEJSgmrVlZa2YEwwgPXK4-tb4zU3tQHNUfdYOPagFL60Gq02DnBV8ZLdUHkca5LU84JQ79LcYD03Ave7y3t_1naV0v7w3FV9PEo2s2rAf2L5ORh7X8-9SE72IYEo4v5BTNWG9OYil0fsQxr7J-mOVVL8v8XfzoqAkw9rFMd-vhL2K6tX3bWGPUXuZeUmg</recordid><startdate>198505</startdate><enddate>198505</enddate><creator>Evangelista, S.</creator><creator>Ciappi, R.</creator><creator>Ortolani, C.</creator><creator>Barzanti, A.</creator><creator>Meli, A.</creator><general>SAGE Publications</general><general>Blackwell Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>198505</creationdate><title>Further studies on the mechanism of fat-free diet (FFD): protection against indomethacin-induced intestinal ulcers in the rat (42072)</title><author>Evangelista, S. ; Ciappi, R. ; Ortolani, C. ; Barzanti, A. ; Meli, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-e7f33193b92928a171da05bde6d4725d700050e54e4c6fe22df65e9e8c10b7d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Dietary Fats - administration & dosage</topic><topic>digestive system diseases</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>enfermedades sistema digestivo</topic><topic>indometacina</topic><topic>indomethacin</topic><topic>Indomethacin - metabolism</topic><topic>Indomethacin - toxicity</topic><topic>indomethacine</topic><topic>Intestinal Diseases - chemically induced</topic><topic>Intestinal Diseases - microbiology</topic><topic>Intestinal Diseases - prevention & control</topic><topic>Intestines - microbiology</topic><topic>maladie de l' appareil digestif</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>rat</topic><topic>rata</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Toxicity: digestive system</topic><topic>Ulcer - chemically induced</topic><topic>Ulcer - microbiology</topic><topic>Ulcer - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Evangelista, S.</creatorcontrib><creatorcontrib>Ciappi, R.</creatorcontrib><creatorcontrib>Ortolani, C.</creatorcontrib><creatorcontrib>Barzanti, A.</creatorcontrib><creatorcontrib>Meli, A.</creatorcontrib><creatorcontrib>AgV Arbeitsgemeinschaft der Verbraucher e.V., Bonn (Germany, F.R.)</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Evangelista, S.</au><au>Ciappi, R.</au><au>Ortolani, C.</au><au>Barzanti, A.</au><au>Meli, A.</au><aucorp>AgV Arbeitsgemeinschaft der Verbraucher e.V., Bonn (Germany, F.R.)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Further studies on the mechanism of fat-free diet (FFD): protection against indomethacin-induced intestinal ulcers in the rat (42072)</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1985-05</date><risdate>1985</risdate><volume>179</volume><issue>1</issue><spage>113</spage><epage>115</epage><pages>113-115</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1525-1373</eissn><eissn>1535-3699</eissn><coden>PSEBAA</coden><abstract>Abstract
A fat-free diet (FFD) reduces bacterial flora when compared to a regular diet (RD) in rats. FFD reduces the degree and incidence of indomethacin-induced intestinal ulceration concomitantly with a reduction in bacterial flora overgrowth produced by the drug. Present and previous findings indicate that diminished deconjugation of indomethacin and reduction of intestinal flora overgrowth play a major role in the ulcer-preventing properties of FFD.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>3991592</pmid><doi>10.3181/00379727-179-42072</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1985-05, Vol.179 (1), p.113-115 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Dietary Fats - administration & dosage digestive system diseases Drug toxicity and drugs side effects treatment enfermedades sistema digestivo indometacina indomethacin Indomethacin - metabolism Indomethacin - toxicity indomethacine Intestinal Diseases - chemically induced Intestinal Diseases - microbiology Intestinal Diseases - prevention & control Intestines - microbiology maladie de l' appareil digestif Male Medical sciences Pharmacology. Drug treatments rat rata Rats Rats, Inbred Strains Toxicity: digestive system Ulcer - chemically induced Ulcer - microbiology Ulcer - prevention & control |
| title | Further studies on the mechanism of fat-free diet (FFD): protection against indomethacin-induced intestinal ulcers in the rat (42072) |
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