Development and evaluation of [ 11 C]DPA-813 and [ 18 F]DPA-814: novel TSPO PET tracers insensitive to human single nucleotide polymorphism rs6971

The translocator protein 18 kDa (TSPO) is a widely used marker for imaging neuroinflammation via Positron Emission Tomography (PET). However, the vast majority of reported TSPO PET tracers display low binding affinity to a common isoform of human TSPO (rs6971; A147T), making them unsuitable for univ...

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Veröffentlicht in:	European journal of nuclear medicine and molecular imaging 2025-02
Hauptverfasser:	Beaino, Wissam, Jm Kooijman, Esther, Werry, Eryn L, Vellinga, Rens J, Van den Hoek, Johan, Sohler, Greta, Cumbers, Grace A, Genetzakis, Elijah, Harvey-Latham, Edward D, Schuit, Robert C, Kassiou, Michael, Windhorst, Albert D, Danon, Jonathan J
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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