YTHDF2-mediated m 6 A modification of ONECUT2 promotes stemness and oxaliplatin resistance in gastric cancer through transcriptionally activating TFPI

Chemoresistance results in poor outcomes of patients with gastric cancer (GC). This study aims to identify oxaliplatin resistance-related cell subpopulations in the tumor microenvironment (TME) and decipher the involved molecular mechanisms. Through single-cell RNA sequencing, a unique ONECUT2 TFPI...

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Veröffentlicht in:	Drug resistance updates 2025-01, Vol.79, p.101200
Hauptverfasser:	Fan, Xingdi, Han, Fangyi, Wang, Haocheng, Shu, Zhilin, Qiu, Bowen, Zeng, Fanan, Chen, Hongzhen, Wu, Ziying, Lin, Yongwei, Lan, Zhien, Ye, Zhiwei, Ying, Yao, Geng, Tiansu, Xian, Ziqian, Niu, Xing, Wu, Junming, Mo, Ke, Zheng, Kehong, Ye, Yaping, Cui, Chunhui
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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