Intrathecal pemetrexed for leptomeningeal metastases in a patient with ALK-rearranged lung adenocarcinoma: a case report

Progressive leptomeningeal metastases (LM) are associated with intractable neurological symptoms and a poor prognosis, and effective treatment options are limited. Intrathecal (IT) pemetrexed has been shown to confer clinical benefit in lung adenocarcinoma, yet our understanding of the efficacy and...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2025-12, Vol.95 (1), p.6, Article 6
Hauptverfasser:	Gezelius, Emelie, Planck, Maria, Hazem, Bassam, Nagpal, Seema, Wakelee, Heather
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma of Lung - drug therapy Adenocarcinoma of Lung - genetics Adenocarcinoma of Lung - pathology Aminopyridines Anaplastic Lymphoma Kinase - genetics Antineoplastic Agents - administration & dosage Antineoplastic Agents - therapeutic use Cancer Research Case Report Female Gene Rearrangement Humans Injections, Spinal Lactams Lung diseases Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - pathology Male Medical treatment Medicine Medicine & Public Health Meningeal Carcinomatosis - drug therapy Meningeal Carcinomatosis - secondary Meningeal Neoplasms - drug therapy Meningeal Neoplasms - secondary Meninges Metastases Middle Aged Oncology Patients Pemetrexed - administration & dosage Pemetrexed - therapeutic use Pharmacology/Toxicology Pyrazoles
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