Loss of Fbxo45 in AT2 cells leads to insufficient histone supply and initiates lung adenocarcinoma

Dysregulation of histone supply is implicated in various cancers, including lung adenocarcinoma (LUAD), although the underlying mechanisms remain poorly understood. Here, we demonstrate that knockout of Fbxo45 in mouse alveolar epithelial type 2 (AT2) cells leads to spontaneous LUAD. Our findings re...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Cell death and differentiation 2024-12
Hauptverfasser:	Li, Lian, Li, Junya, Chen, Ran, Huang, Caihu, Zuo, Yong, Lu, Runhui, Liu, Xiaojia, Huang, Jiayi, Wang, Yanli, Zhao, Xian, Cheng, Jinke, Zhao, Xiaojing, Du, Chunling, Yu, Jianxiu
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!