Design principles to tailor Hsp104 therapeutics

The hexameric AAA+ disaggregase, Hsp104, collaborates with Hsp70 and Hsp40 via its autoregulatory middle domain (MD) to solubilize aggregated proteins. However, how ATP- or ADP-specific MD configurations regulate Hsp104 hexamers remains poorly understood. Here, we define an ATP-specific network of i...

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Veröffentlicht in:	Cell reports (Cambridge) 2024-12, Vol.43 (12), p.115005, Article 115005
Hauptverfasser:	Lin, JiaBei, Carman, Peter J., Gambogi, Craig W., Kendsersky, Nathan M., Chuang, Edward, Gates, Stephanie N., Yokom, Adam L., Rizo, Alexandrea N., Southworth, Daniel R., Shorter, James
Format:	Artikel
Sprache:	eng
Schlagworte:	ALS/FTD disaggregase FUS Hsp104 Hsp70 neurodegeneration protein engineering TDP-43
Online-Zugang:	Volltext
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