Integrating accelerometry, GPS, GIS and molecular data to investigate mechanistic pathways of the urban environmental exposome and cognitive outcomes in older adults: a longitudinal study protocol
IntroductionMaintaining cognitive health in later life is a global priority. Encouraging individuals to make health behaviour changes, such as regular physical activity, and providing supportive urban environments can help maintain cognitive health, thereby preventing or delaying the progress of dem...
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| creator | Hunter, Ruth F Cleland, Claire Trott, Mike O’Neill, Sean Küçükali, Hüseyin Mullineaux, Shay Kee, Frank McKinley, Jennifer M Neville, Charlotte O'Hara, Leeanne Marr, Calum McAlinden, Michael Ellis, Geraint McKnight, Amy Schipperijn, Jasper McHugh Power, Joanna Duong, Trung McGuinness, Bernadette |
| description | IntroductionMaintaining cognitive health in later life is a global priority. Encouraging individuals to make health behaviour changes, such as regular physical activity, and providing supportive urban environments can help maintain cognitive health, thereby preventing or delaying the progress of dementia and cognitive decline. However, the mechanistic pathways by which the urban environmental exposome influences cognitive health outcomes are poorly understood. The aim of this study is to use granular measures of the urban environment exposome (encompassing the built, natural and social environment) and physical activity to explore how these interact with a person’s biology to ultimately influence cognitive health outcomes.Methods and analysisThis ongoing study uses a cohort design, recruiting participants from the Northern Ireland Cohort for the Longitudinal study of Ageing and the Harmonised Cognitive Assessment Protocol study. Participants (n=400 at each wave) will be aged ≥65 years and have the capacity to provide written informed consent. Measures include device-measured physical activity (Actigraph wGT3XP-BT), environmental location data (Global Positioning System, Qstarz BT-Q1000XT), linked to a battery of neuropsychological tests, including the Mini Mental State Examination and the Centre for Epidemiological Studies Depression Scale. Blood-derived biochemical, genetic and epigenetic data will be included in multimodal analyses. These data will be integrated with urban environment Geographic Information System data and analysed using causal inference and mediation methods to investigate plausible mechanistic pathways.Ethics and disseminationThis study has been approved by the Queen’s University Belfast, Faculty of Medicine, Health and Life Sciences Research Ethics Committee (MHLS 21_72). Alongside peer-reviewed publications in high-ranking international journals, dissemination activities include conference presentations, project videos, working papers, policy briefing papers, newsletters, summaries and case study stories. |
| doi_str_mv | 10.1136/bmjopen-2024-085318 |
| format | Article |
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Encouraging individuals to make health behaviour changes, such as regular physical activity, and providing supportive urban environments can help maintain cognitive health, thereby preventing or delaying the progress of dementia and cognitive decline. However, the mechanistic pathways by which the urban environmental exposome influences cognitive health outcomes are poorly understood. The aim of this study is to use granular measures of the urban environment exposome (encompassing the built, natural and social environment) and physical activity to explore how these interact with a person’s biology to ultimately influence cognitive health outcomes.Methods and analysisThis ongoing study uses a cohort design, recruiting participants from the Northern Ireland Cohort for the Longitudinal study of Ageing and the Harmonised Cognitive Assessment Protocol study. Participants (n=400 at each wave) will be aged ≥65 years and have the capacity to provide written informed consent. Measures include device-measured physical activity (Actigraph wGT3XP-BT), environmental location data (Global Positioning System, Qstarz BT-Q1000XT), linked to a battery of neuropsychological tests, including the Mini Mental State Examination and the Centre for Epidemiological Studies Depression Scale. Blood-derived biochemical, genetic and epigenetic data will be included in multimodal analyses. These data will be integrated with urban environment Geographic Information System data and analysed using causal inference and mediation methods to investigate plausible mechanistic pathways.Ethics and disseminationThis study has been approved by the Queen’s University Belfast, Faculty of Medicine, Health and Life Sciences Research Ethics Committee (MHLS 21_72). Alongside peer-reviewed publications in high-ranking international journals, dissemination activities include conference presentations, project videos, working papers, policy briefing papers, newsletters, summaries and case study stories.</description><identifier>ISSN: 2044-6055</identifier><identifier>EISSN: 2044-6055</identifier><identifier>DOI: 10.1136/bmjopen-2024-085318</identifier><identifier>PMID: 39658284</identifier><language>eng</language><publisher>England: British Medical Journal Publishing Group</publisher><subject>Accelerometry ; Aged ; Aging ; Air pollution ; Behavior ; Cognition ; Cognitive ability ; Cognitive Dysfunction - epidemiology ; Dementia ; EPIDEMIOLOGY ; Exercise ; Exposome ; Female ; GENETICS ; Geographic Information Systems ; Global positioning systems ; GPS ; Humans ; Influence ; Investigations ; Longitudinal Studies ; Male ; Neuropsychological Tests ; Noise pollution ; Northern Ireland - epidemiology ; Older people ; Public health ; Public transportation ; Research Design ; Risk factors ; Social interaction ; Social isolation ; Systematic review ; Urban planning</subject><ispartof>BMJ open, 2024-12, Vol.14 (12), p.e085318</ispartof><rights>Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ.</rights><rights>2024 Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-b1904-b38fb78b94a9da9508a0f2566bf1ab3076e5a4adf55907945bf1bb2a6eb4b8453</cites><orcidid>0000-0001-7315-0382 ; 0000-0002-2738-8274 ; 0000-0003-1669-3107 ; 0000-0001-7735-8148 ; 0000-0002-7482-709X ; 0000-0003-2327-5560</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://bmjopen.bmj.com/content/14/12/e085318.full.pdf$$EPDF$$P50$$Gbmj$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://bmjopen.bmj.com/content/14/12/e085318.full$$EHTML$$P50$$Gbmj$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,864,2102,27924,27925,55350,77660,77686</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39658284$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hunter, Ruth F</creatorcontrib><creatorcontrib>Cleland, Claire</creatorcontrib><creatorcontrib>Trott, Mike</creatorcontrib><creatorcontrib>O’Neill, Sean</creatorcontrib><creatorcontrib>Küçükali, Hüseyin</creatorcontrib><creatorcontrib>Mullineaux, Shay</creatorcontrib><creatorcontrib>Kee, Frank</creatorcontrib><creatorcontrib>McKinley, Jennifer M</creatorcontrib><creatorcontrib>Neville, Charlotte</creatorcontrib><creatorcontrib>O'Hara, Leeanne</creatorcontrib><creatorcontrib>Marr, Calum</creatorcontrib><creatorcontrib>McAlinden, Michael</creatorcontrib><creatorcontrib>Ellis, Geraint</creatorcontrib><creatorcontrib>McKnight, Amy</creatorcontrib><creatorcontrib>Schipperijn, Jasper</creatorcontrib><creatorcontrib>McHugh Power, Joanna</creatorcontrib><creatorcontrib>Duong, Trung</creatorcontrib><creatorcontrib>McGuinness, Bernadette</creatorcontrib><title>Integrating accelerometry, GPS, GIS and molecular data to investigate mechanistic pathways of the urban environmental exposome and cognitive outcomes in older adults: a longitudinal study protocol</title><title>BMJ open</title><addtitle>BMJ Open</addtitle><addtitle>BMJ Open</addtitle><description>IntroductionMaintaining cognitive health in later life is a global priority. Encouraging individuals to make health behaviour changes, such as regular physical activity, and providing supportive urban environments can help maintain cognitive health, thereby preventing or delaying the progress of dementia and cognitive decline. However, the mechanistic pathways by which the urban environmental exposome influences cognitive health outcomes are poorly understood. The aim of this study is to use granular measures of the urban environment exposome (encompassing the built, natural and social environment) and physical activity to explore how these interact with a person’s biology to ultimately influence cognitive health outcomes.Methods and analysisThis ongoing study uses a cohort design, recruiting participants from the Northern Ireland Cohort for the Longitudinal study of Ageing and the Harmonised Cognitive Assessment Protocol study. Participants (n=400 at each wave) will be aged ≥65 years and have the capacity to provide written informed consent. Measures include device-measured physical activity (Actigraph wGT3XP-BT), environmental location data (Global Positioning System, Qstarz BT-Q1000XT), linked to a battery of neuropsychological tests, including the Mini Mental State Examination and the Centre for Epidemiological Studies Depression Scale. Blood-derived biochemical, genetic and epigenetic data will be included in multimodal analyses. These data will be integrated with urban environment Geographic Information System data and analysed using causal inference and mediation methods to investigate plausible mechanistic pathways.Ethics and disseminationThis study has been approved by the Queen’s University Belfast, Faculty of Medicine, Health and Life Sciences Research Ethics Committee (MHLS 21_72). 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epidemiology</subject><subject>Older people</subject><subject>Public health</subject><subject>Public transportation</subject><subject>Research Design</subject><subject>Risk factors</subject><subject>Social interaction</subject><subject>Social isolation</subject><subject>Systematic review</subject><subject>Urban planning</subject><issn>2044-6055</issn><issn>2044-6055</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>9YT</sourceid><sourceid>ACMMV</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNpdUttu1DAUjBCIVqVfgIQs8cIDob4n4Q1VtKxUCaTCs3WcOFmvHHuxnYX9v34Y7u5yEX6wj0fjOfZ4quolwe8IYfJKz5uwNb6mmPIat4KR9kl1TjHntcRCPP2nPqsuU9rgMrjohKDPqzPWSdHSlp9XDyufzRQhWz8h6HvjTAyzyXH_Ft1-uS_T6h6BH9AcnOkXBxENkAHlgKzfmZTtBNmg2fRr8LZse7SFvP4B-4TCiPLaoCVq8Mj4nY3Bz8ZncMj83IZU-hyk-zB5m-3OoLDkvqCpaKPgBhMRDIvL6T0C5IKfbF4G68v5VIo92saQQx_ci-rZCC6Zy9N6UX27-fj1-lN99_l2df3hrtakw7zWrB110-qOQzdAJ3ALeKRCSj0S0Aw30gjgMIxCdLjpuCi41hSk0Vy3XLCLanXUHQJs1DbaGeJeBbDqAIQ4KYjFAmcUZ1oPvSbt0HCux-I1I6ajpZ3QUjJStN4ctcojvi_FSDXbVOx34E1YkmKES0kplaxQX_9H3YQlFhsOrKYhkoiusF6dWIuezfDner__uhCujoSSnb8KBKvHQKlToNRjoNQxUOwXJVTAsA</recordid><startdate>20241210</startdate><enddate>20241210</enddate><creator>Hunter, Ruth F</creator><creator>Cleland, Claire</creator><creator>Trott, Mike</creator><creator>O’Neill, Sean</creator><creator>Küçükali, Hüseyin</creator><creator>Mullineaux, Shay</creator><creator>Kee, Frank</creator><creator>McKinley, Jennifer M</creator><creator>Neville, Charlotte</creator><creator>O'Hara, Leeanne</creator><creator>Marr, Calum</creator><creator>McAlinden, Michael</creator><creator>Ellis, Geraint</creator><creator>McKnight, Amy</creator><creator>Schipperijn, Jasper</creator><creator>McHugh Power, Joanna</creator><creator>Duong, Trung</creator><creator>McGuinness, Bernadette</creator><general>British Medical Journal Publishing Group</general><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>9YT</scope><scope>ACMMV</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-7315-0382</orcidid><orcidid>https://orcid.org/0000-0002-2738-8274</orcidid><orcidid>https://orcid.org/0000-0003-1669-3107</orcidid><orcidid>https://orcid.org/0000-0001-7735-8148</orcidid><orcidid>https://orcid.org/0000-0002-7482-709X</orcidid><orcidid>https://orcid.org/0000-0003-2327-5560</orcidid></search><sort><creationdate>20241210</creationdate><title>Integrating accelerometry, GPS, GIS and molecular data to investigate mechanistic pathways of the urban environmental exposome and cognitive outcomes in older adults: a longitudinal study protocol</title><author>Hunter, Ruth F ; Cleland, Claire ; Trott, Mike ; O’Neill, Sean ; Küçükali, Hüseyin ; Mullineaux, Shay ; Kee, Frank ; McKinley, Jennifer M ; Neville, Charlotte ; O'Hara, Leeanne ; Marr, Calum ; McAlinden, Michael ; Ellis, Geraint ; McKnight, Amy ; Schipperijn, Jasper ; McHugh Power, Joanna ; Duong, Trung ; McGuinness, Bernadette</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b1904-b38fb78b94a9da9508a0f2566bf1ab3076e5a4adf55907945bf1bb2a6eb4b8453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Accelerometry</topic><topic>Aged</topic><topic>Aging</topic><topic>Air pollution</topic><topic>Behavior</topic><topic>Cognition</topic><topic>Cognitive ability</topic><topic>Cognitive Dysfunction - epidemiology</topic><topic>Dementia</topic><topic>EPIDEMIOLOGY</topic><topic>Exercise</topic><topic>Exposome</topic><topic>Female</topic><topic>GENETICS</topic><topic>Geographic Information Systems</topic><topic>Global positioning systems</topic><topic>GPS</topic><topic>Humans</topic><topic>Influence</topic><topic>Investigations</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Neuropsychological Tests</topic><topic>Noise pollution</topic><topic>Northern Ireland - epidemiology</topic><topic>Older people</topic><topic>Public health</topic><topic>Public transportation</topic><topic>Research Design</topic><topic>Risk factors</topic><topic>Social interaction</topic><topic>Social isolation</topic><topic>Systematic review</topic><topic>Urban planning</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hunter, Ruth F</creatorcontrib><creatorcontrib>Cleland, Claire</creatorcontrib><creatorcontrib>Trott, Mike</creatorcontrib><creatorcontrib>O’Neill, Sean</creatorcontrib><creatorcontrib>Küçükali, Hüseyin</creatorcontrib><creatorcontrib>Mullineaux, Shay</creatorcontrib><creatorcontrib>Kee, Frank</creatorcontrib><creatorcontrib>McKinley, Jennifer M</creatorcontrib><creatorcontrib>Neville, Charlotte</creatorcontrib><creatorcontrib>O'Hara, Leeanne</creatorcontrib><creatorcontrib>Marr, Calum</creatorcontrib><creatorcontrib>McAlinden, Michael</creatorcontrib><creatorcontrib>Ellis, Geraint</creatorcontrib><creatorcontrib>McKnight, Amy</creatorcontrib><creatorcontrib>Schipperijn, Jasper</creatorcontrib><creatorcontrib>McHugh Power, Joanna</creatorcontrib><creatorcontrib>Duong, Trung</creatorcontrib><creatorcontrib>McGuinness, Bernadette</creatorcontrib><collection>BMJ Open Access Journals</collection><collection>BMJ Journals:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - 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Encouraging individuals to make health behaviour changes, such as regular physical activity, and providing supportive urban environments can help maintain cognitive health, thereby preventing or delaying the progress of dementia and cognitive decline. However, the mechanistic pathways by which the urban environmental exposome influences cognitive health outcomes are poorly understood. The aim of this study is to use granular measures of the urban environment exposome (encompassing the built, natural and social environment) and physical activity to explore how these interact with a person’s biology to ultimately influence cognitive health outcomes.Methods and analysisThis ongoing study uses a cohort design, recruiting participants from the Northern Ireland Cohort for the Longitudinal study of Ageing and the Harmonised Cognitive Assessment Protocol study. Participants (n=400 at each wave) will be aged ≥65 years and have the capacity to provide written informed consent. Measures include device-measured physical activity (Actigraph wGT3XP-BT), environmental location data (Global Positioning System, Qstarz BT-Q1000XT), linked to a battery of neuropsychological tests, including the Mini Mental State Examination and the Centre for Epidemiological Studies Depression Scale. Blood-derived biochemical, genetic and epigenetic data will be included in multimodal analyses. These data will be integrated with urban environment Geographic Information System data and analysed using causal inference and mediation methods to investigate plausible mechanistic pathways.Ethics and disseminationThis study has been approved by the Queen’s University Belfast, Faculty of Medicine, Health and Life Sciences Research Ethics Committee (MHLS 21_72). 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| source | BMJ Open Access Journals; MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Accelerometry Aged Aging Air pollution Behavior Cognition Cognitive ability Cognitive Dysfunction - epidemiology Dementia EPIDEMIOLOGY Exercise Exposome Female GENETICS Geographic Information Systems Global positioning systems GPS Humans Influence Investigations Longitudinal Studies Male Neuropsychological Tests Noise pollution Northern Ireland - epidemiology Older people Public health Public transportation Research Design Risk factors Social interaction Social isolation Systematic review Urban planning |
| title | Integrating accelerometry, GPS, GIS and molecular data to investigate mechanistic pathways of the urban environmental exposome and cognitive outcomes in older adults: a longitudinal study protocol |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T23%3A38%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Integrating%20accelerometry,%20GPS,%20GIS%20and%20molecular%20data%20to%20investigate%20mechanistic%20pathways%20of%20the%20urban%20environmental%20exposome%20and%20cognitive%20outcomes%20in%20older%20adults:%20a%20longitudinal%20study%20protocol&rft.jtitle=BMJ%20open&rft.au=Hunter,%20Ruth%20F&rft.date=2024-12-10&rft.volume=14&rft.issue=12&rft.spage=e085318&rft.pages=e085318-&rft.issn=2044-6055&rft.eissn=2044-6055&rft_id=info:doi/10.1136/bmjopen-2024-085318&rft_dat=%3Cproquest_doaj_%3E3146622263%3C/proquest_doaj_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3147716159&rft_id=info:pmid/39658284&rft_doaj_id=oai_doaj_org_article_43bbdcb18d744bf28431e92f255b6631&rfr_iscdi=true |