One-Step Regioselective Synthesis of N‑1-Substituted Dihydrouracils: A Motif of Growing Popularity in the Targeted Protein Degradation Field

The increasing popularity of the dihydrouracil motif in cereblon (CRBN) recruiting proteolysis-targeting chimeras (PROTACs) has necessitated the development of a facile, cost-effective, and high-yielding method for its introduction into molecules. To that end, we disclose herein an N-1 selective Pd-...

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Veröffentlicht in:	Journal of organic chemistry 2024-12, Vol.89 (24), p.18301-18312
Hauptverfasser:	Nixon, Ian D. G., Bateman, Joseph M., Michaelides, Iacovos N., Fairley, Gary, Pemberton, Miles J., Braybrooke, Erin L., Sutton, Kyran, Lindsay-Scott, Peter J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Molecular Structure Palladium - chemistry Proteolysis Stereoisomerism Uracil - analogs & derivatives Uracil - chemical synthesis Uracil - chemistry
Online-Zugang:	Volltext
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