Design, Synthesis, and Biological Evaluation of [1,2,5]Oxadiazolo[3,4- b ]pyridin-7-ol as Mitochondrial Uncouplers for the Treatment of Obesity and Metabolic Dysfunction-Associated Steatohepatitis

Mitochondrial uncouplers are small molecule protonophores that act to dissipate the proton motive force independent of adenosine triphosphate (ATP) synthase. Mitochondrial uncouplers such as BAM15 increase respiration and energy expenditure and have potential in treating a variety of metabolic disea...

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Veröffentlicht in:	Journal of medicinal chemistry 2024-11
Hauptverfasser:	Foutz, Mary A, Krinos, Emily L, Beretta, Martina, Hargett, Stefan R, Shrestha, Riya, Murray, Jacob H, Duerre, Ethan, Salamoun, Joseph M, McCarter, Katrina, Shah, Divya P, Hoehn, Kyle L, Santos, Webster L
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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