Genomic epidemiology of invasive Group A Streptococcus infections in Argentina, 2023: high prevalence of emm 1-global and detection of emm 1 hypervirulent lineages
The aim of this study is to describe the genomic epidemiology of invasive Group A Streptococcus (iGAS) in Argentina during 2023. A total of 476 invasive GAS isolates were subtyped and analyzed by whole-genome sequencing. A high prevalence of the 1-type strain was observed. Among the 1 strains, two h...
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| Veröffentlicht in: | Microbiology spectrum 2025-01, Vol.13 (1), p.e0131024 |
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| creator | Cipolla, Lucía Gianecini, Ariel Poklepovich, Tomas Etcheverry, Paula Rocca, Florencia Prieto, Mónica |
| description | The aim of this study is to describe the genomic epidemiology of invasive Group A Streptococcus (iGAS) in Argentina during 2023. A total of 476 invasive GAS isolates were subtyped and analyzed by whole-genome sequencing. A high prevalence of the
1-type strain was observed. Among the
1 strains, two highly virulent international variants,
1-UK and
1-DK, were identified. Additionally, a local variant, called
1-ST1319, was detected. This seminal study provides initial insights into the genomic landscape of iGAS, contributing to active surveillance to monitor emerging virulent
1 lineages and cross-border transmission in South America.IMPORTANCEAmid the increase in invasive
infections in Argentina in 2023, the implementation of genomic analysis of isolates allowed us to detect at the national level the prevalence of the
1 type and within the M1 type, emerging national and international hypervirulent lineages. These findings from our report shed light on the distribution of invasive Group A Streptococcus, laying the foundation for genomic surveillance of this pathogen. |
| doi_str_mv | 10.1128/spectrum.01310-24 |
| format | Article |
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1-type strain was observed. Among the
1 strains, two highly virulent international variants,
1-UK and
1-DK, were identified. Additionally, a local variant, called
1-ST1319, was detected. This seminal study provides initial insights into the genomic landscape of iGAS, contributing to active surveillance to monitor emerging virulent
1 lineages and cross-border transmission in South America.IMPORTANCEAmid the increase in invasive
infections in Argentina in 2023, the implementation of genomic analysis of isolates allowed us to detect at the national level the prevalence of the
1 type and within the M1 type, emerging national and international hypervirulent lineages. These findings from our report shed light on the distribution of invasive Group A Streptococcus, laying the foundation for genomic surveillance of this pathogen.</description><identifier>ISSN: 2165-0497</identifier><identifier>EISSN: 2165-0497</identifier><identifier>DOI: 10.1128/spectrum.01310-24</identifier><identifier>PMID: 39611833</identifier><language>eng</language><publisher>United States</publisher><subject>Adolescent ; Adult ; Aged ; Antigens, Bacterial - genetics ; Argentina - epidemiology ; Bacterial Outer Membrane Proteins - genetics ; Carrier Proteins - genetics ; Child ; Child, Preschool ; Female ; Genome, Bacterial - genetics ; Genomics ; Humans ; Infant ; Male ; Middle Aged ; Molecular Epidemiology ; Prevalence ; Streptococcal Infections - epidemiology ; Streptococcal Infections - microbiology ; Streptococcus pyogenes - classification ; Streptococcus pyogenes - genetics ; Streptococcus pyogenes - isolation & purification ; Streptococcus pyogenes - pathogenicity ; Virulence - genetics ; Whole Genome Sequencing ; Young Adult</subject><ispartof>Microbiology spectrum, 2025-01, Vol.13 (1), p.e0131024</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c653-50c97bcf7b01668124986dbaf421a9f984b5b7c361aa858040167abd76af1f783</cites><orcidid>0000-0001-8370-1010 ; 0000-0003-2932-0537 ; 0000-0002-0663-4456</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,861,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39611833$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Atack, John M.</contributor><creatorcontrib>Cipolla, Lucía</creatorcontrib><creatorcontrib>Gianecini, Ariel</creatorcontrib><creatorcontrib>Poklepovich, Tomas</creatorcontrib><creatorcontrib>Etcheverry, Paula</creatorcontrib><creatorcontrib>Rocca, Florencia</creatorcontrib><creatorcontrib>Prieto, Mónica</creatorcontrib><title>Genomic epidemiology of invasive Group A Streptococcus infections in Argentina, 2023: high prevalence of emm 1-global and detection of emm 1 hypervirulent lineages</title><title>Microbiology spectrum</title><addtitle>Microbiol Spectr</addtitle><description>The aim of this study is to describe the genomic epidemiology of invasive Group A Streptococcus (iGAS) in Argentina during 2023. A total of 476 invasive GAS isolates were subtyped and analyzed by whole-genome sequencing. A high prevalence of the
1-type strain was observed. Among the
1 strains, two highly virulent international variants,
1-UK and
1-DK, were identified. Additionally, a local variant, called
1-ST1319, was detected. This seminal study provides initial insights into the genomic landscape of iGAS, contributing to active surveillance to monitor emerging virulent
1 lineages and cross-border transmission in South America.IMPORTANCEAmid the increase in invasive
infections in Argentina in 2023, the implementation of genomic analysis of isolates allowed us to detect at the national level the prevalence of the
1 type and within the M1 type, emerging national and international hypervirulent lineages. These findings from our report shed light on the distribution of invasive Group A Streptococcus, laying the foundation for genomic surveillance of this pathogen.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Antigens, Bacterial - genetics</subject><subject>Argentina - epidemiology</subject><subject>Bacterial Outer Membrane Proteins - genetics</subject><subject>Carrier Proteins - genetics</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Genome, Bacterial - genetics</subject><subject>Genomics</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Molecular Epidemiology</subject><subject>Prevalence</subject><subject>Streptococcal Infections - epidemiology</subject><subject>Streptococcal Infections - microbiology</subject><subject>Streptococcus pyogenes - classification</subject><subject>Streptococcus pyogenes - genetics</subject><subject>Streptococcus pyogenes - isolation & purification</subject><subject>Streptococcus pyogenes - pathogenicity</subject><subject>Virulence - genetics</subject><subject>Whole Genome Sequencing</subject><subject>Young Adult</subject><issn>2165-0497</issn><issn>2165-0497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkN9KwzAUh4Mobsw9gDeSB7AzJ-lf78bQKQy8cPclTU-6SNuUpB3seXxRO-eGV-cH53y_Ax8h98AWADx98h2q3g3NgoEAFvDwikw5xFHAwiy5_pcnZO79F2MMgEU84rdkIrIYIBViSr7X2NrGKIqdKbExtrbVgVpNTbuX3uyRrp0dOrqkn73DrrfKKjX4ca3H98a2x0iXrsK2N618pJxx8Ux3ptrRzuFe1tgqPBZi01AIqtoWsqayLWmJ_anisqW7Q4dub9wwUj2tTYuyQn9HbrSsPc7_5oxsX1-2q7dg87F-Xy03gYojEURMZUmhdFIwiOMUeJilcVlIHXKQmc7SsIiKRIkYpEyjlIXjWSKLMomlBp2kYkbgVKuc9d6hzjtnGukOObD8qDw_K89_lec8HJmHE9MNRYPlhTgLFj81a4Cv</recordid><startdate>20250107</startdate><enddate>20250107</enddate><creator>Cipolla, Lucía</creator><creator>Gianecini, Ariel</creator><creator>Poklepovich, Tomas</creator><creator>Etcheverry, Paula</creator><creator>Rocca, Florencia</creator><creator>Prieto, Mónica</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0001-8370-1010</orcidid><orcidid>https://orcid.org/0000-0003-2932-0537</orcidid><orcidid>https://orcid.org/0000-0002-0663-4456</orcidid></search><sort><creationdate>20250107</creationdate><title>Genomic epidemiology of invasive Group A Streptococcus infections in Argentina, 2023: high prevalence of emm 1-global and detection of emm 1 hypervirulent lineages</title><author>Cipolla, Lucía ; Gianecini, Ariel ; Poklepovich, Tomas ; Etcheverry, Paula ; Rocca, Florencia ; Prieto, Mónica</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c653-50c97bcf7b01668124986dbaf421a9f984b5b7c361aa858040167abd76af1f783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Antigens, Bacterial - genetics</topic><topic>Argentina - epidemiology</topic><topic>Bacterial Outer Membrane Proteins - genetics</topic><topic>Carrier Proteins - genetics</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Genome, Bacterial - genetics</topic><topic>Genomics</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Molecular Epidemiology</topic><topic>Prevalence</topic><topic>Streptococcal Infections - epidemiology</topic><topic>Streptococcal Infections - microbiology</topic><topic>Streptococcus pyogenes - classification</topic><topic>Streptococcus pyogenes - genetics</topic><topic>Streptococcus pyogenes - isolation & purification</topic><topic>Streptococcus pyogenes - pathogenicity</topic><topic>Virulence - genetics</topic><topic>Whole Genome Sequencing</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cipolla, Lucía</creatorcontrib><creatorcontrib>Gianecini, Ariel</creatorcontrib><creatorcontrib>Poklepovich, Tomas</creatorcontrib><creatorcontrib>Etcheverry, Paula</creatorcontrib><creatorcontrib>Rocca, Florencia</creatorcontrib><creatorcontrib>Prieto, Mónica</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Microbiology spectrum</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cipolla, Lucía</au><au>Gianecini, Ariel</au><au>Poklepovich, Tomas</au><au>Etcheverry, Paula</au><au>Rocca, Florencia</au><au>Prieto, Mónica</au><au>Atack, John M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genomic epidemiology of invasive Group A Streptococcus infections in Argentina, 2023: high prevalence of emm 1-global and detection of emm 1 hypervirulent lineages</atitle><jtitle>Microbiology spectrum</jtitle><addtitle>Microbiol Spectr</addtitle><date>2025-01-07</date><risdate>2025</risdate><volume>13</volume><issue>1</issue><spage>e0131024</spage><pages>e0131024-</pages><issn>2165-0497</issn><eissn>2165-0497</eissn><abstract>The aim of this study is to describe the genomic epidemiology of invasive Group A Streptococcus (iGAS) in Argentina during 2023. A total of 476 invasive GAS isolates were subtyped and analyzed by whole-genome sequencing. A high prevalence of the
1-type strain was observed. Among the
1 strains, two highly virulent international variants,
1-UK and
1-DK, were identified. Additionally, a local variant, called
1-ST1319, was detected. This seminal study provides initial insights into the genomic landscape of iGAS, contributing to active surveillance to monitor emerging virulent
1 lineages and cross-border transmission in South America.IMPORTANCEAmid the increase in invasive
infections in Argentina in 2023, the implementation of genomic analysis of isolates allowed us to detect at the national level the prevalence of the
1 type and within the M1 type, emerging national and international hypervirulent lineages. These findings from our report shed light on the distribution of invasive Group A Streptococcus, laying the foundation for genomic surveillance of this pathogen.</abstract><cop>United States</cop><pmid>39611833</pmid><doi>10.1128/spectrum.01310-24</doi><orcidid>https://orcid.org/0000-0001-8370-1010</orcidid><orcidid>https://orcid.org/0000-0003-2932-0537</orcidid><orcidid>https://orcid.org/0000-0002-0663-4456</orcidid></addata></record> |
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| subjects | Adolescent Adult Aged Antigens, Bacterial - genetics Argentina - epidemiology Bacterial Outer Membrane Proteins - genetics Carrier Proteins - genetics Child Child, Preschool Female Genome, Bacterial - genetics Genomics Humans Infant Male Middle Aged Molecular Epidemiology Prevalence Streptococcal Infections - epidemiology Streptococcal Infections - microbiology Streptococcus pyogenes - classification Streptococcus pyogenes - genetics Streptococcus pyogenes - isolation & purification Streptococcus pyogenes - pathogenicity Virulence - genetics Whole Genome Sequencing Young Adult |
| title | Genomic epidemiology of invasive Group A Streptococcus infections in Argentina, 2023: high prevalence of emm 1-global and detection of emm 1 hypervirulent lineages |
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