Microsomal Prostaglandin E Synthase-1 Controls Colonic Prostaglandin E 2 Production and Exerts a Protective Effect on Colitis Induced by Trinitrobenzene Sulfonic Acid in Mice

Microsomal prostaglandin E synthase-1 (mPGES-1) is an isozyme of the prostaglandin (PG) E synthase that acts downstream of cyclooxygenase and catalyzes the conversion of PGH to PGE . The impact of genetic deletion of mPGES-1 on the development of 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced co...

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Veröffentlicht in:	International journal of molecular sciences 2024-11, Vol.25 (22)
Hauptverfasser:	Kojima, Fumiaki, Hioki, Yuka, Sekiya, Hiroki, Kashiwagi, Hitoshi, Iizuka, Yoshiko, Eto, Kei, Maehana, Shotaro, Kawakami, Fumitaka, Kubo, Makoto, Ishibashi, Hitoshi, Ichikawa, Takafumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Colitis - chemically induced Colitis - genetics Colitis - metabolism Colitis - pathology Colon - metabolism Colon - pathology Dinoprostone - metabolism Disease Models, Animal Interferon-gamma - metabolism Interleukin-17 - genetics Interleukin-17 - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Microsomes - metabolism Prostaglandin-E Synthases - genetics Prostaglandin-E Synthases - metabolism Trinitrobenzenesulfonic Acid - toxicity
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