A potent and selective anti-glutathione peroxidase 4 nanobody as a ferroptosis inducer

Glutathione peroxidase 4 (GPX4) plays a crucial role in the ferroptosis pathway, emerging as a potential drug target in the treatment of refractory tumors. Unfortunately, the development of GPX4-targeted treatment has been very limited due to the poor selectivity and drug-like properties of current...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Chemical science (Cambridge) 2024-11, Vol.15 (46), p.1942-19431
Hauptverfasser:	Li, Xinyu, Li, Yaru, Xie, Aowei, Chen, Fenglin, Wang, Jing, Zhou, Jianfeng, Xu, Ximing, Xu, Zhenlin, Wang, Yong, Qiu, Xue
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Ferroptosis Glutathione Peroxidase Selectivity Zebrafish
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!