Synergistic Attention-Guided Cascaded Graph Diffusion Model for Complementarity Determining Region Synthesis

Complementarity determining region (CDR) is a specific region in antibody molecules that binds to antigens, where a small portion of residues undergoes particularly pronounced variations. Generating CDRs with high affinity and specificity is a pivotal milestone in accelerating drug development for d...

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Veröffentlicht in:	IEEE transaction on neural networks and learning systems 2024-11, Vol.PP, p.1-12
Hauptverfasser:	Zhang, Rongchao, Huang, Yu, Lou, Yiwei, Ding, Weiping, Cao, Yongzhi, Wang, Hanpin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation models Amino acids Antibodies Biological system modeling Cascaded diffusion model complementarity determining region (CDR) synthesis Computational modeling Diffusion models Drugs Predictive models protein drug design Protein engineering Proteins synergistic graph attention
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