The cell cycle inhibitor p21 CIP1 is essential for irinotecan-induced senescence and plays a decisive role in re-sensitization of temozolomide-resistant glioblastoma cells to irinotecan

Standard of care for glioblastomas includes radio-chemotherapy with the monoalkylating compound temozolomide. Temozolomide induces primarily senescence, inefficiently killing glioblastoma cells. Recurrences are inevitable. Although recurrences presumably arise from cells evading/escaping TMZ-induced...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2024-11, Vol.181, p.117634
Hauptverfasser:	Sallbach, Jason, Woods, Melanie, Rasenberger, Birgit, Christmann, Markus, Tomicic, Maja T
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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