111 Ag phantom images with Cerenkov Luminescence Imaging and digital autoradiography within the ISOLPHARM project
Targeted Radionuclide Therapy (TRT) is a medical technique exploiting radionuclides to combat cancer growth and spread. TRT requires a supply of radionuclides that are currently produced by either cyclotrons or nuclear research reactors. In this context, the ISOLPHARM project investigates the produc...
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| Veröffentlicht in: | Applied radiation and isotopes 2025-01, Vol.215, p.111562 |
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| creator | Serafini, Davide Zancopè, Nicola Pavone, Anna Maria Benfante, Viviana Arzenton, Alberto Russo, Vincenzo Ballan, Michele Morselli, Luca Cammarata, Francesco Paolo Comelli, Albert Russo, Giorgio Scopelliti, Fabrizio Di Marco, Valerio Mastrotto, Francesca Asti, Mattia Maniglio, Devid Sbarra, Carla Bortolussi, Silva Donzella, Antonietta Zenoni, Aldo Gandini, Andrea Villa, Valerio Paderno, Diego Zangrando, Lisa Corradetti, Stefano Mariotti, Emilio Salvini, Andrea Torrisi, Filippo Lunardon, Marcello Andrighetto, Alberto |
| description | Targeted Radionuclide Therapy (TRT) is a medical technique exploiting radionuclides to combat cancer growth and spread. TRT requires a supply of radionuclides that are currently produced by either cyclotrons or nuclear research reactors. In this context, the ISOLPHARM project investigates the production of innovative radionuclides for medical applications. This production will be based on the forthcoming SPES facility at the Legnaro National Laboratories (LNL) of the National Institute for Nuclear Physics (INFN), an ISOL facility where high-purity radioactive beams will be used to produce carrier-free radiopharmaceuticals. Previous studies demonstrated that a significant amount of
Ag, an innovative β/γ emitter suitable for TRT with theranostic applications, can be obtained at the SPES facility. The present work describes the first imaging study on phantoms with
Ag performed by the ISOLPHARM collaboration. This is a fundamental step to pave the way for the upcoming in vivo studies on the
Ag-based radiopharmaceutical currently being developed. The imaging potential of this radionuclide was investigated by acquiring phantom images with Cerenkov Luminescence Imaging (CLI) and digital autoradiography (ARG). |
| doi_str_mv | 10.1016/j.apradiso.2024.111562 |
| format | Article |
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Ag, an innovative β/γ emitter suitable for TRT with theranostic applications, can be obtained at the SPES facility. The present work describes the first imaging study on phantoms with
Ag performed by the ISOLPHARM collaboration. This is a fundamental step to pave the way for the upcoming in vivo studies on the
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Ag, an innovative β/γ emitter suitable for TRT with theranostic applications, can be obtained at the SPES facility. The present work describes the first imaging study on phantoms with
Ag performed by the ISOLPHARM collaboration. This is a fundamental step to pave the way for the upcoming in vivo studies on the
Ag-based radiopharmaceutical currently being developed. 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TRT requires a supply of radionuclides that are currently produced by either cyclotrons or nuclear research reactors. In this context, the ISOLPHARM project investigates the production of innovative radionuclides for medical applications. This production will be based on the forthcoming SPES facility at the Legnaro National Laboratories (LNL) of the National Institute for Nuclear Physics (INFN), an ISOL facility where high-purity radioactive beams will be used to produce carrier-free radiopharmaceuticals. Previous studies demonstrated that a significant amount of
Ag, an innovative β/γ emitter suitable for TRT with theranostic applications, can be obtained at the SPES facility. The present work describes the first imaging study on phantoms with
Ag performed by the ISOLPHARM collaboration. This is a fundamental step to pave the way for the upcoming in vivo studies on the
Ag-based radiopharmaceutical currently being developed. The imaging potential of this radionuclide was investigated by acquiring phantom images with Cerenkov Luminescence Imaging (CLI) and digital autoradiography (ARG).</abstract><cop>England</cop><pmid>39488936</pmid><doi>10.1016/j.apradiso.2024.111562</doi></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 1872-9800 |
| ispartof | Applied radiation and isotopes, 2025-01, Vol.215, p.111562 |
| issn | 1872-9800 |
| language | eng |
| recordid | cdi_pubmed_primary_39488936 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Autoradiography - methods Humans Luminescence Luminescent Measurements - methods Phantoms, Imaging Radiopharmaceuticals - pharmacokinetics |
| title | 111 Ag phantom images with Cerenkov Luminescence Imaging and digital autoradiography within the ISOLPHARM project |
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