Assessment of post-pyeloplasty renal drainage in antenatally detected hydronephrosis by 99m Tc-L, L-Ethylenedicysteine renal scintigraphy: the importance of delayed imaging
Diuretic renal scintigraphy is important in diagnosing pelvi-ureteric junction obstruction (PUJO) in antenatally detected hydronephrotic (ANH) kidneys. Early-phase dynamic renal scintigraphy has several pitfalls contributing to the false interpretation of obstructed drainage, especially after pyelop...
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| creator | Aggarwal, Piyush Gunasekaran, Vinisha Gowtham, M Mahajan, Jai K Sood, Ashwani Mittal, Bhagwant R Menon, Prema Peters, Nitin James Malik, Muneer A Bhattacharya, Anish |
| description | Diuretic renal scintigraphy is important in diagnosing pelvi-ureteric junction obstruction (PUJO) in antenatally detected hydronephrotic (ANH) kidneys. Early-phase dynamic renal scintigraphy has several pitfalls contributing to the false interpretation of obstructed drainage, especially after pyeloplasty. This study explores the utility of delayed imaging in
Tc-L,L-Ethylenedicysteine (EC) diuretic renal scintigraphy to assess post-pyeloplasty renal drainage in ANH.
Data from May 2019 to January 2024 was retrospectively studied to identify infants with ANH who underwent surgery for PUJO and pre-and post-surgical assessment of renal drainage using
Tc-L,L-EC diuretic renal scintigraphy. Dynamic and post-void static images were analyzed to calculate percentage drainage till 3 h. Pre- and post-operative quantitative parameters were compared. Receiver operator curve analysis was done to calculate the threshold drainage to detect renal obstruction on postvoid images.
In a cohort of 104 patients with a mean age of 10.1 ± 6.5 months (range 2-36 months) at surgery, 106 renal units (bilateral involvement in two patients) were analyzed. There was no significant difference in the sum of obstructive and equivocal curve patterns (105 vs 79, p = 0.06) and T
values (105 vs 82, p = 0.093) before and after surgery. However, there was a significant difference between the pre-and post-surgery median 3-h percentage drainage (26 vs 80%, p |
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Tc-L,L-Ethylenedicysteine (EC) diuretic renal scintigraphy to assess post-pyeloplasty renal drainage in ANH.
Data from May 2019 to January 2024 was retrospectively studied to identify infants with ANH who underwent surgery for PUJO and pre-and post-surgical assessment of renal drainage using
Tc-L,L-EC diuretic renal scintigraphy. Dynamic and post-void static images were analyzed to calculate percentage drainage till 3 h. Pre- and post-operative quantitative parameters were compared. Receiver operator curve analysis was done to calculate the threshold drainage to detect renal obstruction on postvoid images.
In a cohort of 104 patients with a mean age of 10.1 ± 6.5 months (range 2-36 months) at surgery, 106 renal units (bilateral involvement in two patients) were analyzed. There was no significant difference in the sum of obstructive and equivocal curve patterns (105 vs 79, p = 0.06) and T
values (105 vs 82, p = 0.093) before and after surgery. However, there was a significant difference between the pre-and post-surgery median 3-h percentage drainage (26 vs 80%, p < 0.001). A drainage threshold of less than 59% at 3 h had 93.4% sensitivity and 92.5% specificity to detect obstructive drainage.
Delayed images in diuretic renal scintigraphy are crucial in accurately interpreting post-pyeloplasty drainage patterns and help overcome pitfalls of the dynamic study.</description><identifier>EISSN: 1864-6433</identifier><identifier>PMID: 39485619</identifier><language>eng</language><publisher>Japan</publisher><ispartof>Annals of nuclear medicine, 2024-11</ispartof><rights>2024. The Author(s) under exclusive licence to The Japanese Society of Nuclear Medicine.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-2752-4416</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39485619$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aggarwal, Piyush</creatorcontrib><creatorcontrib>Gunasekaran, Vinisha</creatorcontrib><creatorcontrib>Gowtham, M</creatorcontrib><creatorcontrib>Mahajan, Jai K</creatorcontrib><creatorcontrib>Sood, Ashwani</creatorcontrib><creatorcontrib>Mittal, Bhagwant R</creatorcontrib><creatorcontrib>Menon, Prema</creatorcontrib><creatorcontrib>Peters, Nitin James</creatorcontrib><creatorcontrib>Malik, Muneer A</creatorcontrib><creatorcontrib>Bhattacharya, Anish</creatorcontrib><title>Assessment of post-pyeloplasty renal drainage in antenatally detected hydronephrosis by 99m Tc-L, L-Ethylenedicysteine renal scintigraphy: the importance of delayed imaging</title><title>Annals of nuclear medicine</title><addtitle>Ann Nucl Med</addtitle><description>Diuretic renal scintigraphy is important in diagnosing pelvi-ureteric junction obstruction (PUJO) in antenatally detected hydronephrotic (ANH) kidneys. Early-phase dynamic renal scintigraphy has several pitfalls contributing to the false interpretation of obstructed drainage, especially after pyeloplasty. This study explores the utility of delayed imaging in
Tc-L,L-Ethylenedicysteine (EC) diuretic renal scintigraphy to assess post-pyeloplasty renal drainage in ANH.
Data from May 2019 to January 2024 was retrospectively studied to identify infants with ANH who underwent surgery for PUJO and pre-and post-surgical assessment of renal drainage using
Tc-L,L-EC diuretic renal scintigraphy. Dynamic and post-void static images were analyzed to calculate percentage drainage till 3 h. Pre- and post-operative quantitative parameters were compared. Receiver operator curve analysis was done to calculate the threshold drainage to detect renal obstruction on postvoid images.
In a cohort of 104 patients with a mean age of 10.1 ± 6.5 months (range 2-36 months) at surgery, 106 renal units (bilateral involvement in two patients) were analyzed. There was no significant difference in the sum of obstructive and equivocal curve patterns (105 vs 79, p = 0.06) and T
values (105 vs 82, p = 0.093) before and after surgery. However, there was a significant difference between the pre-and post-surgery median 3-h percentage drainage (26 vs 80%, p < 0.001). A drainage threshold of less than 59% at 3 h had 93.4% sensitivity and 92.5% specificity to detect obstructive drainage.
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Tc-L,L-Ethylenedicysteine (EC) diuretic renal scintigraphy to assess post-pyeloplasty renal drainage in ANH.
Data from May 2019 to January 2024 was retrospectively studied to identify infants with ANH who underwent surgery for PUJO and pre-and post-surgical assessment of renal drainage using
Tc-L,L-EC diuretic renal scintigraphy. Dynamic and post-void static images were analyzed to calculate percentage drainage till 3 h. Pre- and post-operative quantitative parameters were compared. Receiver operator curve analysis was done to calculate the threshold drainage to detect renal obstruction on postvoid images.
In a cohort of 104 patients with a mean age of 10.1 ± 6.5 months (range 2-36 months) at surgery, 106 renal units (bilateral involvement in two patients) were analyzed. There was no significant difference in the sum of obstructive and equivocal curve patterns (105 vs 79, p = 0.06) and T
values (105 vs 82, p = 0.093) before and after surgery. However, there was a significant difference between the pre-and post-surgery median 3-h percentage drainage (26 vs 80%, p < 0.001). A drainage threshold of less than 59% at 3 h had 93.4% sensitivity and 92.5% specificity to detect obstructive drainage.
Delayed images in diuretic renal scintigraphy are crucial in accurately interpreting post-pyeloplasty drainage patterns and help overcome pitfalls of the dynamic study.</abstract><cop>Japan</cop><pmid>39485619</pmid><orcidid>https://orcid.org/0000-0002-2752-4416</orcidid></addata></record> |
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| title | Assessment of post-pyeloplasty renal drainage in antenatally detected hydronephrosis by 99m Tc-L, L-Ethylenedicysteine renal scintigraphy: the importance of delayed imaging |
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