Novel pyrimidine linked acyl thiourea derivatives as potent α-amylase and proteinase K inhibitors: design, synthesis, molecular docking and ADME studies

To discover promising therapeutic agents, novel diaryl pyrimidine linked acyl thiourea derivatives ( 6aj ) were designed and synthesized via straightforward and multistep synthesis. The structure of these derivatives ( 6a-j ) was confirmed by FTIR, 1 H, and 13 C NMR spectroscopic techniques. The in...

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Veröffentlicht in:	RSC advances 2024-10, Vol.14 (45), p.33235-33246
Hauptverfasser:	Zaman, Hina, Saeed, Aamer, Ismail, Hammad, Anwaar, Sadaf, Latif, Muhammad, Hashmi, Muhammad Zaffar, El-Seedi, Hesham R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amylases Chemical synthesis Chemistry Molecular docking Molecular structure NMR Nuclear magnetic resonance Pharmacology Proteinase Pyrimidines Thiourea derivatives
Online-Zugang:	Volltext
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