Serotonin-2B receptor (5-HT 2B R) expression and binding in the brain of APP swe /PS1 dE9 transgenic mice and in Alzheimer's disease brain tissue

Despite well-documented dysregulation in central serotonergic signaling in Alzheimer's disease (AD), knowledge about the potential involvement of the serotonin-2B receptor (5-HT R) subtype remains sparse. Here, we assessed the levels of 5-HT Rs in brain tissue from APP /PS1 transgenic (TG) mice...

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Veröffentlicht in:	Neuroscience letters 2025-01, Vol.844, p.138013
Hauptverfasser:	Anzalone, Marco, Karam, Sarmad A, Briting, Sanne R R, Petersen, Sussanne, Thomsen, Majken B, Babcock, Alicia A, Landau, Anne M, Finsen, Bente, Metaxas, Athanasios
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - pathology Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Animals Brain - metabolism Female Humans Male Mice Mice, Transgenic Microglia - metabolism Receptor, Serotonin, 5-HT2B - genetics Receptor, Serotonin, 5-HT2B - metabolism RNA, Messenger - metabolism
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